Publications by authors named "Hakan Basir"
Evaluation of peripheral blood inflammatory biomarkers in sickle cell disease with and without retinopathy.
Graefes Arch Clin Exp Ophthalmol
December 2024
Background: The aim of this study was to evaluate the clinical significance of blood-cell associated inflammation markers in patients with sickle cell disease (SCD) and sickle cell retinopathy (SCR).
Methods: Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), systemic immune inflammation index (SIII), systemic inflammation response index (SIRI), systemic inflammation modulation index (SIMI) and aggregate systemic inflammation index (AISI) were calculated. This study included 45 healthy controls (Group 1) and 100 SCD (Group 2).
Article Synopsis
- Acute pancreatitis (AP) is a leading gastrointestinal condition causing hospitalization, with a focus on evaluating its clinical features and adherence to international management guidelines.
- The study analyzed 2,144 hospitalized AP patients in Turkey, finding that most cases were mild, with biliary causes being the most common, and an overall mortality rate of 1.6%.
- Results indicate good predictive accuracy for severe cases using specific scoring systems, but show inconsistent adherence to treatment guidelines, particularly in administering prophylactic measures like NSAIDs and antibiotics.
Introduction Primary myelofibrosis (PM) has a lower overall survival rate than other myeloproliferative neoplasms, and leukemic transformation is the most common cause of death. Increased oxidative stress has an important role in leukemic transformation in these patients. In this study, we aimed to find an answer to the question, "Could Ruxolitinib, which has been widely used in patients with myelofibrosis in recent years, have a role in reducing oxidative stress in these patients?".
View Article and Find Full Text PDFBackground: The trio Essential Thrombocytosis (ET), Polycythemia Vera (PV), and Primary Myelofibrosis (PM) are BCR-ABL negative myeloproliferative neoplasms. All three diseases have the risk of transforming into acute leukemia. Oxidative stress and some genetic mutations increase the risk of leukemic transformation.
View Article and Find Full Text PDFIntroduction and aim Sickle cell anemia (SCA) is the most common hemoglobinopathy worldwide, and cardiovascular diseases are the most common causes of death. In these patients, cardiac remodeling begins from childhood and leads to sickle cell cardiomyopathy in the following years. Concentric hypertrophy and eccentric hypertrophy are known to predict early cardiac events.
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