Siderophore-based targeted antibody recruitment for promoting immune responses towards Gram-negative pathogens.

Antibody-recruiting molecules (ARMs) have emerged as a promising strategy for enhancing immune responses against pathogens and cancer cells. In this study, we developed a novel class of antibacterial ARMs utilizing siderophores, small iron-chelating compounds, as targeting motifs. Siderophores naturally exhibit high specificity for bacterial pathogens due to their role in iron acquisition, making them ideal candidates for selective targeting.

Effect of Light Regime on Puniceispirillum marinum IMCC1322 in Nutrient-Replete Conditions.

Previous studies showed no improvement in bacterial biomass for Puniceispirillum marinum IMCC1322 under light regimes. Nevertheless, in nutrient-replete cultures with higher inoculating cell densities, strain IMCC1322 exhibited proteorhodopsin photoheterotrophy. Increasing both inoculum size and the amino acid pool can eliminate quorum sensing and starvation responses in strain IMCC1322.

Increased diagnosis of hepato-biliary-pancreatic cancer after cholecystectomy: a population-based study.

Given the increasing trend of cholecystectomy, it is imperative to reassess surgical and surveillance strategies in consideration of the potential long-term risks for digestive tract cancers. The objective of this study was to assess the risk of gastrointestinal (GI) and hepato-biliary-pancreatic (HBP) cancer incidence after cholecystectomy. The data for this cohort study was obtained from the National Health Insurance Service database in Korea.

Results of arthroscopic lateral ligament repair according to the arthroscopic classification of anterior talofibular ligament remnants.

Background: This study aimed to compare the clinical and radiologic outcomes among grades according to the arthroscopic classification of chronic ATFL lesions after arthroscopic lateral ligament repair.

Methods: We retrospectively analyzed 135 patients with chronic lateral ankle instability who underwent arthroscopic lateral ligament repair at 3 institutions between 2018 and 2020. The patients were divided into four groups according to the arthroscopic classification of the ATFL remnants.

Hallux valgus interphalangeus is more common in juvenile-onset hallux valgus than in adult-onset hallux valgus.

Background: This study aimed to compare the prevalence of hallux valgus interphalangeus (HVI) in juvenile-onset hallux valgus and adult-onset hallux valgus and to analyze the correlation between the hallux interphalangeal angle (HIA) and other radiographic parameters in juvenile-onset hallux valgus.

Methods: This retrospective study included 640 feet and 320 patients with hallux valgus (160 juvenile-onset and 160 adult-onset cases). Eight radiographic parameters were measured: HIA, hallux valgus angle, intermetatarsal angle, talonavicular coverage angle, anteroposterior talocalcaneal angle, lateral talocalcaneal angle, lateral talo-first metatarsal angle, and calcaneal pitch.

Prevalence and outcomes of nonmass lesions detected on screening breast ultrasound based on ultrasound features.

Purpose: To determine how often non-mass lesions are seen in screening breast ultrasounds, and analyze their ultrasound features according to the ultrasound lexicon to find features suggestive of malignant non-mass lesions.

Methods: This study is a single center retrospective study for nonmass lesions on screening breast ultrasound. Among 21,604 patients who underwent screening breast US, there were 279 patients with nonmass lesions.

Postoperative outcome of screw fixation with autogenous bone grafting for the management of hallux sesamoid fracture nonunion.

Introduction: Although sesamoid-preserving procedures have been attempted to complement sesamoidectomy for hallux sesamoid fracture nonunion, few reports document the results. Accordingly, the objective of this study was to review the outcomes of patients with hallux sesamoid fracture nonunion who underwent screw fixation with autogenous bone grafting.

Materials And Methods: Medical records of patients who underwent surgery between January 2013 and September 2022 were reviewed.

Nonmass Lesions on Breast Ultrasound: Interreader Agreement and Associations With Malignancy.

Nonmass lesions (NMLs) on breast ultrasound lack clear definition and encompass a broad range of benign and malignant entities. Given anticipated inclusion of NMLs in the BI-RADS 6th edition, thorough understanding of these lesions will be critical for optimal management. To evaluate interreader agreement for classification of lesions on breast ultrasound as NMLs and to identify imaging features associated with malignancy in these lesions.

Exposure to Radiofrequency Electromagnetic Fields Enhances Melanin Synthesis by Activating the P53 Signaling Pathway in Mel-Ab Melanocytes.

The skin is the largest body organ that can be physiologically affected by exposure to radiofrequency electromagnetic fields (RF-EMFs). We investigated the effect of RF-EMFs on melanogenesis; Mel-Ab melanocytes were exposed to 1760 MHz radiation with a specific absorption rate of 4.0 W/kg for 4 h/day over 4 days.

Functionalized Triangular Carbon Quantum Dot Stabilized Gold Nanoparticles Decorated Boron Nitride Nanosheets Interfaced for Electrochemical Detection of Cardiac Troponin T.

The fast, and highly sensitive estimation of cardiac troponin T (cTnT) is crucial for the early identification of acute myocardial infarction (AMI). The electrochemical immunoassay-based (EIB) sensors are highly promising for this purpose, as they offer precise measurements and can be directly assessed in intricate matrices, including blood. To increase sensitivity, EIB sensors use nanomaterials or amplification processes, which can be laborious to develop.

Structural and Phase Engineering of a Hierarchical 2D-2D Nickel MOF/Hydroxide-Derived NiSe/NiTe Heterointerface for Robust HER, OER, and Overall Water Splitting.

The development of a nonnoble metal-based cost-effective, efficient, and durable bifunctional electrocatalyst is crucial to achieving the goal of carbon neutrality. In this study, a structural and interfacial engineering approach is employed to design a 2D-2D hierarchical nickel MOF/nickel hydroxide-derived nickel selenide/nickel telluride dual-phase material through a single-step selenotellurization process. The rational design of highly ordered nanoarchitectures provides well-defined voids and ample pathways for ion diffusion.

Performance of high-resolution diffusion-weighted magnetic resonance imaging for detecting clinically occult early breast cancers: a multi-reader study.

Purpose: To compare mammography, breast ultrasound (US), high-resolution diffusion-weighted magnetic resonance imaging (DW-MRI), dynamic contrast-enhanced breast MRI (DCE-MRI), and their combinations for detecting clinically occult early breast cancers (EBCs), including ductal carcinoma in situ (DCIS).

Methods: Three hundred and three consecutive women with screening imaging-detected early breast cancers (60 pure DCIS, 36 DCIS with microinvasion, and 207 invasive carcinoma less than 20 mm) who underwent breast MRI at 3 T including DW-MRI (b-values of 0, 800 and 1200 s/mm; in-plane resolution, 1.1 × 1.

Assessment of Nonmass Lesions Detected with Screening Breast US Based on Mammographic Findings.

Background Breast nonmass lesions (NMLs) are observed at screening and diagnostic US. However, knowledge is limited on imaging features of NMLs at screening US. Purpose To identify features of NMLs at screening US that are suspicious for malignancy based on mammographic findings.

5'-tRNA halves generated by IRE1α are linked to the ER stress response.

Transfer RNA halves (tRHs) have various biological functions. However, the biogenesis of specific 5'-tRHs under certain conditions remains unknown. Here, we report that inositol-requiring enzyme 1α (IRE1α) cleaves the anticodon stem-loop region of tRNA to produce 5'-tRHs (5'-tRH-Gly) with highly selective target discrimination upon endoplasmic reticulum (ER) stress.

Optimizing target and diaphragmatic configuration, and dosimetric benefits using continuous positive airway pressure in stereotactic ablative radiotherapy for lung tumors.

Purpose: This study aimed to evaluate the impact of facilitating target delineation of continuous positive airway pressure (CPAP) in patients undergoing stereotactic ablative radiation therapy (SABR) for lung tumors by lung expansion and respiratory motion management.

Materials And Methods: We performed a prospective single-institutional trial of patients who were diagnosed with either primary lung cancer or lung metastases and received SABR with a dose of 40 to 60 Gy in 4 fractions. Four-dimensional computed tomography simulations were conducted for each patient: once without CPAP and again with CPAP.

Exposure to Radiofrequency Induces Synaptic Dysfunction in Cortical Neurons Causing Learning and Memory Alteration in Early Postnatal Mice.

The widespread use of wireless communication devices has necessitated unavoidable exposure to radiofrequency electromagnetic fields (RF-EMF). In particular, increasing RF-EMF exposure among children is primarily driven by mobile phone use. Therefore, this study investigated the effects of 1850 MHz RF-EMF exposure at a specific absorption rate of 4.

Comparative analysis of delivered and planned doses in target volumes for lung stereotactic ablative radiotherapy.

Background: Adaptive therapy has been enormously improved based on the art of generating adaptive computed tomography (ACT) from planning CT (PCT) and the on-board image used for the patient setup. Exploiting the ACT, this study evaluated the dose delivered to patients with non-small-cell lung cancer (NSCLC) patients treated with stereotactic ablative radiotherapy (SABR) and derived relationship between the delivered dose and the parameters obtained through the evaluation procedure.

Methods: SABR treatment records of 72 patients with NSCLC who were prescribed a dose of 60 Gy (D) to the 95% volume of the planning target volume (PTV) in four fractions were analysed in this retrospective study; 288 ACTs were generated by rigid and deformable registration of a PCT to a cone-beam computed tomography (CBCT) per fraction.