This study reports a hybrid lipo-polymeric nanosystem (PDPC NPs) synthesized by a modified hydrogel-isolation technique. The ability of the nanosystem to encapsulate hydrophilic and hydrophobic molecules has been demonstrated, and their enhanced cellular uptake has been observed . The PDPC NPs, surface coated with gold by reduction of chloroauric acid (PDPC-Au NPs), showed a photothermal transduction efficacy of ∼65%.
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