[Aging and hepatocarcinogenesis].

Aging is characterized by a progressive decline in the efficiency of physiological function and by the increased susceptibility to disease. Recently, the prevalence of elderly hepatocel- lular carcinoma (HCC) has been increasing in Japan. Inflammation, DNA-damaging agents (reactive oxygen and nitrogen species), methylation/ demethylation of DNA, and shortening of the telomere will lead.

Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma.

Unlabelled: MicroRNA (miRNA) plays an important role in the pathology of various diseases, including infection and cancer. Using real-time polymerase chain reaction, we measured the expression of 188 miRNAs in liver tissues obtained from 12 patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and 14 patients with hepatitis C virus (HCV)-related HCC, including background liver tissues and normal liver tissues obtained from nine patients. Global gene expression in the same tissues was analyzed via complementary DNA microarray to examine whether the differentially expressed miRNAs could regulate their target genes.