Publications by authors named "Hajime Morohashi"

Purpose: Chemoradiotherapy (CRT) for rectal cancer is limited by its harmful side effects and its insufficient benefit on lateral lymph node metastases. The purpose of this study was to evaluate the long-term outcomes of S-1 and oxaliplatin with total mesorectal excision (TME) and lateral lymph node dissection (LLND) without radiation for rectal cancer.

Methods: The inclusion criteria were patients with stage II or III rectal cancer located within 10 cm from the anal verge.

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  • * Japan began researching telesurgery in 2002, but implementation was slow due to insufficient telecommunications and a lack of support for robotic surgery.
  • * Recently, the Japan Surgical Society is leading feasibility studies for telesurgery amid growing demand for online medical services, with other countries like China, India, and the U.S. also exploring similar clinical studies, indicating a shift towards broader adoption of telesurgery.
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Aim: To clarify the usefulness of intraoperative lavage cytology in patients undergoing curative resection for pStage II-III colorectal cancer in a prospective multicenter study.

Methods: Patients preoperatively diagnosed with stage II-III colorectal cancer between 2013 and 2017 from 20 hospitals were enrolled. Lavage cytology was performed twice during the surgery.

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  • NAD + is crucial for various cellular functions and lower levels may be linked to cancer, sparking interest in how it changes in cancer patients undergoing surgery.
  • This study analyzed NAD + dynamics in 99 patients with different digestive cancers by measuring blood samples and found that while NAD + levels stayed stable post-surgery, nicotinamide mononucleotide (NMN) levels dropped and recovered differently based on cancer type.
  • The research suggests that understanding individual NAD + levels could lead to personalized supplementation strategies for cancer patients during treatment.
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  • * Advances in technology and new surgical robots have mitigated previous challenges, leading to a legal framework in Japan since 2019 that supports remote surgical assistance under a surgeon's supervision.
  • * The Japan Surgical Society developed "Telesurgery Guidelines" in June 2022, outlining standards for medical teams, communication protocols, robotic systems, and addressing issues like responsibility and adverse events, with plans for ongoing updates.
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The patient is a 63-year-old man. He visited his previous physician for abdominal pain. After close examinations, he was diagnosed with stenotic sigmoid colon cancer with left lateral lymph node metastasis.

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  • * Out of 32 patients, a significant portion had advanced disease features, with about 40% having previously undergone colostomy; NAC was completed in 81.2% of cases, and the surgery successfully preserved sphincter function in many patients.
  • * Results showed that NAC had a positive impact on around half of patients, suggesting the addition of radiotherapy for those who do not respond well to NAC alone.
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Assuring communication redundancy during the interruption and establishing appropriate teaching environments for local surgeons are essential to making robotic telesurgery mainstream. This study analyzes robotic telesurgery with telementoring using standard domestic telecommunication carriers. Can multiple carriers guarantee redundancy with interruptions? Three commercial optical fiber lines connected Hirosaki University and Mutsu General Hospitals, 150 km apart.

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Purpose: To evaluate the impact of dual cockpit telesurgery on proctors and operators, and acceptable levels of processing delay for video compression and restoration.

Methods: Eight medical advisors and eight trainee surgeons, one highly skilled per group, performed gastrectomy, rectal resection, cholecystectomy, and bleeding tasks on pigs. Using the Medicaroid surgical robot hinotori, simulated delay times (0 ms, 50 ms, 100 ms, 150 ms, and 200 ms) were inserted mid-surgery to evaluate the tolerance level.

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  • Telementoring in robotic surgery is affected by teaching methods, especially since surgery involves complex 3D structures.
  • A study with 20 medical students using 3D drawing annotations showed better performance compared to voice and 2D annotations, including shorter operation times and fewer retries.
  • The 3D annotation group scored higher on surgical skill assessments, suggesting it enhances comprehension and efficiency in surgical procedures.
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The purpose of this study is to evaluate the performance of tele-robotic distal gastrectomy (tele-RDG) with lymph node dissection (LND) using a novel Japanese-made surgical robot hinotori™ (Medicaroid, Kobe, Japan) in a cadaver with a presumptive gastric cancer. The Cadaveric Anatomy and Surgical Training Laboratory (CAST-Lab.) at Hokkaido University and Kushiro City General Hospital (KCGH) are connected by a guaranteed type line (1 Gbps), and the distance between the two facilities is 250 km.

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  • - This study aimed to assess the effectiveness of haptic feedback during telesurgery to enhance safety in robotic surgery practices.
  • - Experiments involved a surgeon operating from two separate locations, and while no significant impact on task accuracy was found, the remote operations resulted in longer completion times and lower usability ratings.
  • - Haptic feedback allowed surgeons to use lighter grasping forces, particularly benefiting experienced surgeons, highlighting its potential as a crucial tool for safe and effective telerobotic surgery.
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  • The study focused on the relationship between extramural vascular invasion (EMVI) and tumor deposits (TD) in rectal cancer (RC) patients and their response to neoadjuvant chemotherapy (NAC).
  • It compared two groups of surgical patients: those who were resistant to NAC (had EMVI and TD) and those who were effective responders (lacked EMVI and TD), using proteomic analysis and immunohistochemistry for validation.
  • Results showed that NAC-resistant patients had a significantly lower 3-year disease-free survival rate, and the expression of the protein SELENBP1 was notably decreased in the resistance group, suggesting its role in NAC resistance and poor prognosis.
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  • This study introduces a double-surgeon cockpit system for telesurgery, marking a significant step in developing a clinically applicable telesurgical technique.
  • It involved non-specialized surgeons performing surgeries on pigs with remote assistance and evaluated the effect of internet security measures on communication during procedures.
  • Results showed promising outcomes, with non-specialized surgeons performing safely and effectively, indicating the feasibility of this system as a foundation for future clinical telesurgery.
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Aim: Communication and video transmission delays negatively affect telerobotic surgery. Since latency varies by communication environment and robot, to realize remote surgery, both must perform well. This study aims to examine the feasibility of telerobotic surgery by validating the communication environment and local/remote robot operation, using secure commercial lines and newly developed robots.

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Although robotic telesurgery is growing in popularity, the benefits of telesurgery compared to local surgery are unclear. This study aimed to evaluate the performance of robotic tele-cholecystectomy with a commercial line using the Saroa (Riverfield, Inc., Tokyo, Japan) system.

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Introduction: Telerobotic surgery relies on communication lines, causing delays, and video information requires pre-transmission compression. Such delays and video degradation will continue to be unavoidable making communication conditions verification essential. Understanding the network specification values required for telerobotic surgery entails determining acceptable levels of delay and degradation due to the video compression and restoration processes during surgery.

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Background: Emphysematous pancreatitis is acute pancreatitis associated with emphysema based on imaging studies and has been considered a subtype of necrotizing pancreatitis. Although some recent studies have reported the successful use of conservative treatment, it is still considered a serious condition. Computed tomography (CT) scan is useful in identifying emphysema associated with acute pancreatitis; however, whether the presence of emphysema correlates with the severity of pancreatitis remains controversial.

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We investigated 36 patients with Stage Ⅳ rectal cancer who underwent primary resection in our department between November 2015 and June 2020. Tumor localization was upper in 20 cases and lower in 16 cases. Six patients had the cT4b stage at initial diagnosis, and lateral lymph node metastases were detected in 6 cases.

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Background: Remote surgery social implementation necessitates achieving low latency and highly reliable video/operation signal transmission over economical commercial networks. However, with commercial lines, communication bandwidth often fluctuates with network congestion and interference from narrowband lines acting as bottlenecks. Therefore, verifying the effects on surgical performance and surgeon fatigue when communication lines dip below required bandwidths are important.

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Purpose: We investigated the communication bandwidth (CB) limitation for remote robotics surgery (RRS) using hinotori™ (Medicaroid, Kobe, Japan).

Methods: The operating rooms of the Hokkaido University Hospital and Kyushu University Hospital were connected using the Science Information NETwork (SINET). The minimum required CB for the RRS was verified by decreasing the CB from 500 to 100 Mbps.

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Background: Determine whether robotic surgery is more effective than transanal and conventional laparoscopic surgery in preserving bowel and urinary function after total mesorectal excision (TME).

Methods: Of 79 lower rectal cancer patients who underwent function-preserving TME between 2016 and 2020, 64 patients consented to a prospective questionnaire-based functional observation study (52 responded). At 6 months post-resection or ileostomy closure, Wexner, low anterior resection syndrome (LARS), modified fecal incontinence quality of life, and international prostate symptom scores were used to evaluate bowel and urinary function, comparing robotic surgery (RTME) with transanal (taTME) or conventional laparoscopic surgery (LTME).

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