Publications by authors named "Hajime Komano"
Article Synopsis
- Understanding the early molecular pathologies of neurodegenerative diseases like spinocerebellar ataxia type 1 (SCA1) can lead to better treatments for these conditions.
- This study focused on the earliest developmental changes in SCA1 by analyzing RNA-seq data from patient-derived stem cells transforming into Purkinje cells, which are crucial for motor control.
- The findings highlighted the involvement of specific histone and immune response genes in early SCA1 pathology, particularly noting the role of ISG15 in the degradation of mutant ataxin-1 within Purkinje cells.
Sumoylation is a post-translational modification process that is supposed to be implicated in the pathogenesis of several neurodegenerative diseases. Recently, the microtubule-associated protein Tau was identified as a target for sumoylation in the analysis of the transfected cells. We investigated the localization of SUMO-1 protein in APP transgenic mice and mutant Tau transgenic mice, and found that SUMO-1 immunoreactivity was co-localized with phosphorylated Tau aggregates in amyloid plaques of APP transgenic mice.
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