Publications by authors named "Hajime Inokuchi"
J Rheumatol
December 2024
Article Synopsis
- Tocilizumab (TCZ) is an effective treatment for giant cell arteritis (GCA), but its impact on treatment changes and outcomes following relapses or discontinuations due to adverse events (AEs) is not well studied.
- In a retrospective study of 62 GCA patients receiving TCZ, 16% experienced relapses, often after dosage adjustments or stopping TCZ; most relapses were manageable with treatment modifications.
- About 45% of patients experienced AEs, with a small portion discontinuing TCZ; those who used alternative immunosuppressive therapies had better outcomes in managing GCA and avoiding relapses.
Rheumatol Int
December 2024
Article Synopsis
- - Inflammatory bowel disease (IBD), particularly ulcerative colitis and Crohn's disease, causes both intestinal inflammation and extra-intestinal issues like spondyloarthritis, with current treatments having limitations.
- - Janus kinase inhibitors, such as upadacitinib and tofacitinib, have shown effectiveness in treating IBD and associated spondyloarthritis, though their impact specifically on Crohn's disease-related spondyloarthritis was previously unexamined.
- - The presentation of two successful cases of Crohn's disease-related peripheral spondyloarthritis treated with upadacitinib, alongside a literature review, indicates a promising future for Janus kinase inhibitors as a new treatment option for both
Mod Rheumatol Case Rep
January 2025
Article Synopsis
- Eosinophilic granulomatosis with polyangiitis (EGPA) is a complex condition that complicates diagnosis due to its diverse symptoms, as illustrated by a 59-year-old woman with asthma and sinusitis who presented with rare skin blisters and nerve issues.
- Medical examinations showed elevated eosinophils, a specific antibody related to neutrophils, and signs of small vessel inflammation, leading to the diagnosis of EGPA.
- Treatment with glucocorticoids and cyclophosphamide resulted in significant improvement, highlighting the importance of recognizing unusual skin lesions for early diagnosis and intervention to prevent serious complications.
