Publications by authors named "Hajime Higaki"
Article Synopsis
- Tri-weekly cisplatin (CDDP) combined with radiotherapy (RT) is the standard treatment for locally advanced head and neck squamous cell carcinoma (LA-HNSCC), but it's tough for older patients, prompting a study on weekly CDDP + RT instead.
- The study focused on patients aged 70 and older, analyzing treatment outcomes for those who received weekly CDDP + RT from 2006 to 2022, measuring overall survival (OS), progression-free survival (PFS), and cause-specific survival (CSS).
- Results indicated that patients had a median age of 72, with high survival rates over 3 years: 80.9% OS, 68.3% PFS
Glioblastoma is the most common of malignant primary brain tumors and one of the tumors with the poorest prognosis for which the overall survival rate has not significantly improved despite recent advances in treatment techniques and therapeutic drugs. Since the emergence of immune checkpoint inhibitors, the immune response to tumors has attracted increasing attention. Treatments affecting the immune system have been attempted for various tumors, including glioblastomas, but little has been shown to be effective.
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- The study aimed to validate the Graded Prognostic Assessment for lung cancer (Lung-molGPA) in Japanese non-small cell lung cancer (NSCLC) patients with brain metastasis (BM) by analyzing factors affecting survival.
- A retrospective analysis of 294 NSCLC patients treated with radiotherapy revealed median overall survival (OS) times significantly varied based on GPA scores and treatment history, particularly noting the benefits of osimertinib in adenocarcinoma patients with gene mutations.
- Although survival varied across PD-L1 expression levels, the differences were not statistically significant, indicating that other factors might play a more critical role in survival outcomes for patients with BM.
Most oncogenic human papilloma virus (HPV) genotypes stratify into two species, α-7 HPV and α-9 HPV. There are several studies that evaluate the relationship between HPV species and treatment outcomes and reports that HPV species is prognostic. The HPV genotyping was conducted using biopsy specimens which had been stored in these studies.
View Article and Find Full Text PDFGraded Prognostic Assessment (GPA) for Patients With Lung Cancer and Brain Metastases: Initial Report of the Small Cell Lung Cancer GPA and Update of the Non-Small Cell Lung Cancer GPA Including the Effect of Programmed Death Ligand 1 and Other Prognostic Factors.
Int J Radiat Oncol Biol Phys
September 2022
Article Synopsis
- This study aims to present the first graded prognostic assessment (GPA) for small cell lung cancer (SCLC) and to examine the impact of PD-L1 on survival rates in non-small cell lung cancer (NSCLC), while also updating the existing Lung GPA based on new findings.
- The analysis was conducted on a large group of 4,183 lung cancer patients with brain metastases, identifying key prognostic factors that influence survival across different types of lung cancer.
- Results indicated varying median survival rates based on the type of lung cancer and GPA, with significant findings showing that PD-L1 expression is a predictive factor for survival, particularly in lung adenocarcinoma patients.