Current Trends of Drug Resistance Patterns of Infection in Blood Transfusion-dependent Thalassemia Patients.

Objective: The present study aimed to evaluate the current trends of drug resistance patterns of infection in blood transfusion-dependent thalassemia patients.

Study Design: This study was a cross sectional study, conducted at the Liaquat University of Medical and Health Sciences, Jamshoro/Hyderabad, Sindh, Pakistan from October 2014 to January 2016.

Subjects And Methods: Of 921 blood samples, strains were isolated from 100 blood samples.

Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus.

Objectives: Causality of occurrence of metformin-associated lactic acidosis (MALA) is a clinical problem. Currently, there is no drug available to prevent MALA. The present study was conducted to evaluate the protective effect of Berberine (BBR) against MALA in induced diabetic rat model.

Serum enolase-2, high-sensitivity C-reactive protein, and serum cholesterol in smear-positive drug-naïve pulmonary tuberculosis.

Background: Pulmonary tuberculosis (PTB) is a chronic granulomatous disease caused by . The present study determined the serum human enolase-2 (ENO-2), high-sensitive C-reactive protein (hs-CRP), and serum cholesterol levels as biological marker of disease activity and treatment response in smear-positive drug-naïve PTB.

Materials And Methods: This case-control study was done in the Department of Medicine, Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro/Hyderabad, Sindh, from January 2015 to April 2016.

QTc-interval, heart rate variability and postural hypotension as an indicator of cardiac autonomic neuropathy in type 2 diabetic patients.

Objective: To evaluate the QTc-interval, heart rate variability and postural hypotension in predicting cardiac autonomic neruopathy (CAN) in type 2 diabetes mellitus (DM) patients

Methods: The comparative cross-sectional study was conducted in the Department of Medicine, Muhammad Medical College Hospital, Mirpurkhas, Sindh, from September 2008 to December 2009. A total of 186 type-2 diabetes mellitus patients with a QTc value of > 440 ms were studied. The QT interval was measured on electrocardiographic (ECG) recordings.

A comparative study of the typhidot (Dot-EIA) and Widal tests in blood culture positive cases of typhoid fever.

Seventy-six blood culture positive typhoid cases and forty-eight controls were studied. The typhidot test was positive in 74 (97.36%) cases, with a sensitivity, specificity and positive predictive value of 96%, 89.

Drug resistance patterns in pulmonary tuberculosis.

Objective: To determine the resistance patterns of mycobacterium tuberculosis (MTB) isolates among category I and II patients of pulmonary tuberculosis.

Methods: This cross sectional study was conducted at the Department of Medicine, Liaquat University of Medical and Health Sciences Jamshoro, from November 2008 to September 2009. Patients were divided into category I and II.

Cardiac autonomic neuropathy (CAN) in type-1 diabetes mellitus patients and its association with the duration of disease and glycemic control.

Objective: To determine the frequency of Cardiac Autonomic Neuropathy (CAN) in type-1 Diabetes mellitus patients and its association with the duration of disease and glycemic control.

Study Design: Descriptive study.

Place And Duration Of Study: Department of Medicine, Liaquat University Hospital, Hyderabad/Jamshoro, from December, 2004 to April, 2005.

Thrombocytopenia in plasmodium falciparum malaria.

Background: Malaria is usually associated with reduced blood cell counts & mild to moderate thrombocytopenia is a common association of malaria. The cause of thrombocytopenia is poorly understood, but the immune-mediated lysis, sequestration in the spleen and dyspoietic processes in the marrow with diminished platelet production have all been postulated. This study was conducted to evaluate thrombocytopenia in the patients suffering from acute Plasmodium falciparum malaria.

Frequency of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus reporting at a teaching hospital of Sindh.

Objective: To determine the frequency of Cardiac Autonomic Neuropathy (CAN) in patients with type 2 Diabetes mellitus.

Study Design: Descriptive study.

Place And Duration Of Study: Department of Medicine, Liaquat University Hospital, Jamshoro, Hyderabad from December 2004 to April 2005.