Publications by authors named "Hajer Bin Shuraym"
Article Synopsis
- * Researchers created a library of 111 genetically modified Aspergillus fumigatus mutants to identify important antifungal targets, discovering that a specific kinase, YakA, is crucial for regulating susceptibility to azoles and pathogenicity.
- * The study found that inhibiting YakA not only weakens the fungus's ability to grow and invade tissues but also enhances the effectiveness of azoles when combined with a compound (1-ECBC), suggesting a potential avenue for improving treatment.
More than 10 million people suffer from lung diseases caused by the pathogenic fungus . The azole class of antifungals represent first line therapeutics for most of these infections however resistance is rising. Identification of novel antifungal targets that, when inhibited, synergise with the azoles will aid the development of agents that can improve therapeutic outcomes and supress the emergence of resistance.
View Article and Find Full Text PDFAspergillosis, in its various manifestations, is a major cause of morbidity and mortality. Very few classes of antifungal drugs have been approved for clinical use to treat these diseases and resistance to the first-line therapeutic class, the triazoles are increasing. A new class of antifungals that target pyrimidine biosynthesis, the orotomides, are currently in development with the first compound in this class, olorofim in late-stage clinical trials.
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