The expression of NLR family pyrin domain containing receptor 1 in Brazilian psoriatic patients is associated with increased disease severity and pro-inflammatory cytokine release.

This study aimed to investigate the gene and protein expression of key inflammasome mediators in venous blood and skin biopsy samples from Brazilian psoriatic patients treated at the Pedro Ernesto University Hospital (HUPE). Samples were collected from both psoriatic patients and healthy controls. Gene expression was evaluated using quantitative reverse transcription polymerase chain reaction (qRT‒PCR), while protein levels were assessed through immunohistochemistry and multiplex immunoassays.