Publications by authors named "Haizhu Shi"

Article Synopsis
  • Triple-negative breast cancer (TNBC) is a challenging type of breast cancer without specific treatment targets, primarily relying on traditional chemotherapy methods, making it essential to explore new therapeutic strategies.
  • Researchers engineered extracellular vesicles (EVs) using RNA nanotechnology to deliver targeted therapies specifically to TNBC cells by optimizing them with survivin small interfering RNA (siRNA) and CD44 aptamer ligands.
  • The study found that these engineered EVs dramatically reduced the required doses of chemotherapy drugs like gemcitabine and paclitaxel, showing effective tumor growth inhibition while potentially minimizing side effects associated with standard chemotherapy treatments.
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Rapid separation and enrichment of targets in biological matrixes are of significant interest in multiple life sciences disciplines. Molecularly imprinted polymers (MIPs) have vital applications in extraction and sample cleanup owing to their excellent specificity and selectivity. However, the low mass transfer rate, caused by the heterogeneity of imprinted cavities in polymer networks and strong driving forces, significantly limits its application in high-throughput analysis.

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Screening bioactive compounds from natural products is one of the most effective ways for new drug research and development. However, obtaining a single extract component on a large scale and with high purity from a complex matrix is still an arduous and challenging task. Herein, one metal mediated magnetic molecularly imprinted polymer (mMIP) was rationally designed and prepared for specifically capturing Aristolochic acid I (AAI).

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Here, a molecularly imprinted electrochemical sensor (MIECS) was designed and fabricated for specifically monitoring norfloxacin (NFX), an entirely synthetic antibiotic. In which, Cu dopped covalent organic framework (COF) was used to connect NFX imprinting layer and glassy carbon electrode through covalence. Under optimized conditions, the linear range is as wide as 5 orders of magnitude, and the detection limit is 5.

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A magnetic molecularly imprinted polymer was developed with an epitope peptide of human VEGF as a template an epitope blotting technique. As a drug-free agent, the nanoparticles can significantly suppress the proliferation of tumor cells by integrating anti-angiogenesis and photothermotherapy. This work provides a successful example of the design of multimodal antineoplastic drugs.

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Bacterial infections remain a major cause of morbidity worldwide due to drug resistance of pathogenic bacteria. Photodynamic therapy (PDT) has emerged as a promising approach to overcome this drug resistance. However, existing photosensitizers (PSs) are broad-spectrum antibacterial agents that dysregulate the microflora balance resulting in undesirable side effects.

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Anthocyanins have been reported to have potential as dietary or pharmaceutical supplements in the application of cancer prevention and adjunctive treatment. However, there are few studies on the effect of anthocyanins on melanoma, which have only been performed in cell lines. The objective of this work was to investigate the anticancer effects and mechanisms of bilberry anthocyanin extract (BAE) on melanoma In Vitro and In Vivo.

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Due to the polygenic and heterogeneous nature of the tumorigenesis process, traditional chemotherapy is far from desirable. Fabricating multifunctional nanoplatforms integrating photodynamic effect can synergistically enhance chemotherapy because they can make the cancer cells much sensitive to chemotherapeutics. However, how to assemble different units in nanoplatforms and minimize side effects caused by chemodrugs and photosensitizers (PSs) still needs to be explored.

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Recently, metal mediated molecularly imprinted polymers (MMIPs) raise extensive attention due to their special adsorption/desorption mechanism. And the metal ion plays a key role both for MMIPs preparation and molecular recognition. But it is still a big question to select one suitable metal ion.

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As one kind of artificial antibody, molecularly imprinted polymers (MIPs) has been widely used to separate/enrich target molecules from samples with the complex matrix prior to instrumental analysis. In this work, one novel copper mediated magnetic MIPs was developed towards anti-bacteria macrolide antibiotic tylosin (TYL). The obtained microspheres had a lot of convexities distributed evenly on the surface.

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Norfloxacin (NFX) is an antibiotic that is widely used in animal husbandry. However, the presence of NFX even in trace amounts in animal-derived food may harm human health. Therefore, it is of practical significance to establish a method for monitoring NFX residues in food.

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Molecularly imprinted polymers (MIPs) are a kind of synthetic receptor-like materials. They have drawn more and more attention in the past decades. In this work, a facile method was developed to prepare porous magnetic MIPs utilizing metal coordination.

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The human biological monitoring of metals (metalloids) is of importance, which concentrations could indicate a wide range of health related information. Reference values (RVs) of metals (metalloids) in specific matix of populations are critically required when performing a statistical evaluation accurately. Recent studies show that RVs of metals (metalloids) are influenced by many multiple factors, including lifestyle, diet, dissimilar environment, location, as well as race.

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A glassy carbon electrode (GCE) was consecutively modified with amino groups and phosphate groups, and then loaded with Zr(IV) ions. Fourier transform infrared spectrophotometry, field-emission scanning electron microscopy, energy dispersive X-ray spectroscopy and cyclic voltammetry were used to characterize the morphologies and electrochemical properties. The sensor was used to detect p-nitrophenyl-substituted organophosphorus pesticides, with methyl-parathion (MP) as the model analyte.

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The main object of the study was to discover the associated significantly different metabolites between Han and Uygur, two main racial groups in Xinjiang, China with urinary metabolomics. Urine samples from 96 Han and 96 Uygur were analyzed using gas chromatography coupled to mass spectrometry (GCMS). Multivariate analysis was used to investigate the effect of race, age and gender on the urinary metabolomic profiles.

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