Oral Delivery of Mouse β-Defensin 14 (mBD14)-Producing NZ9000 Attenuates Experimental Colitis in Mice.

Antimicrobial peptides (AMPs) play essential roles in maintaining intestinal health and have been suggested as possible therapeutic strategies against inflammatory bowel disease (IBD). However, the instability of AMPs in the process of transmission limits their application in the treatment of IBD. In this study, we constructed the mBD14-producing NZ9000 (/mBD14) to achieve enteric delivery of mBD14 and evaluated its protective effect on dextran sodium sulfate (DSS)-induced colitis.