Remote ischemic preconditioning-induced late cardioprotection: possible role of melatonin-mitoKATP-H2S signaling pathway.

Purpose: Remote ischemic preconditioning (RIPC) confers cardioprotection against ischemia reperfusion (IR) injury. However, the precise mechanisms involved in RIPC-induced cardioprotection are not fully explored. The present study was aimed to identify the role of melatonin in RIPC-induced late cardioprotective effects in rats and to explore the role of H2S, TNF-α and mitoKATP in melatonin-mediated effects in RIPC.

Antitumor activity and safety evaluation of nanaparticle-based delivery of quercetin through intravenous administration in mice.

The present study focused on the inhibition effects and the safety evaluation of the quercetin when it was loaded into the nanoliposomes on cervical cancer in vitro and in vivo. Quercetin loaded nanoliposomes (Que-NLs) were first prepared by thin film hydration method and the characterizations of Que-NLs were measured with TEM and dynamic light scattering (DLS) techniques. Then the anti-cervical cancer efficiencies were evaluated by MTT and U14 tumor-bearing mice models in vitro and in vivo respectively.

Prescription consisting of Vitamin C and Baicalin inhibits tumor growth by enhancing the antioxidant capacity in vivo.

Purpose: To explore the antitumor effect of prescription consisting of Vitamin C (Vc) and Baicalin (PVB).

Methods: To explore the antitumor effect of PVB, using U14 cervical tumor-bearing mice model was used and the drugs were administrated through the gavages. Spectrophotometry was used to determine the content of superoxide dismutase (SOD), malondialdehyde (MDA) and cytokines IL-2, Il-4 and IFN-γ.