State-specific GluCEST alterations in insular subregions are associated with depression and plasma inflammatory biomarker levels in patients with inflammatory bowel disease.

Background: Depression commonly co-occurs with inflammatory bowel disease (IBD). Abnormal glutamate levels in the insula and altered plasma inflammatory biomarkers are observed in IBD and depression. However, the changes in glutamate concentrations in insular subregions in IBD and their relationship with depression and inflammatory markers remain unclear.

PANoptosis-related genes: Molecular insights into immune dysregulation in ulcerative colitis.

Background And Aim: Ulcerative colitis (UC) is a chronic inflammatory disease driven by immune dysregulation. PANoptosis, a novel form of programmed cell death, has been implicated in inflammatory diseases, but its specific role in UC remains unclear. This study aimed to identify PANoptosis-related genes (PRGs) that may contribute to immune dysregulation in UC.

Clinical performance of a particle enhanced turbidimetric immunoassay (PETIA) for detecting fecal calprotectin.

Particle-enhanced turbidimetric immunoassay (PETIA) is a new measurement procedure for detecting fecal calprotectin (FC). We aimed to investigate the accuracy and clinical performance of PETIA for FC. We assessed the accuracy of PETIA for FC measurements through concordance analysis, Passing-Bablok regression and Bland-Altman analysis, using enzyme-linked immunosorbent assay (ELISA) as the reference.

Identifying the importance of PCK1 in maintaining ileal epithelial barrier integrity in Crohn's disease.

Background: Crohn's disease (CD) is marked by disruption of intestinal epithelial barrier, with unclear underlying molecular mechanisms. This study aimed to investigate key genes regulating the intestinal barrier in CD patients.

Methods: Differential gene expression analysis and gene set enrichment analysis were conducted to identify potential key genes involved in CD within the GEO database.

TH1L involvement in colorectal cancer pathogenesis by regulation of CCL20 through the NF-κB signalling pathway.

TH1L (also known as NELF-C/D) is a member of the Negative Elongation Factor (NELF) complex, which is a metazoan-specific factor that regulates RNA Polymerase II (RNAPII) pausing and transcription elongation. However, the function and molecular mechanisms of TH1L in cancer progression are still largely unknown. In this study, we found that TH1L was highly expressed in colorectal cancer (CRC) tissues and the faeces of CRC patients.

Effects of interaction of multiple large-scale atmospheric circulations on precipitation dynamics in China.

Different scenarios of precipitation, that lead to such phenomena as droughts and floods are influenced by concurrent multiple teleconnection factors. However, the multivariate relationship between precipitation indices and teleconnection factors, including large-scale atmospheric circulations and sea surface temperature signals in China, is rarely explored. Understanding this relationship is crucial for drought early warning systems and effective response strategies.

Computed tomography-based body composition parameters can predict short-term prognosis in ulcerative colitis patients.

Objectives: Emerging evidence suggests a potential relationship between body composition and short-term prognosis of ulcerative colitis (UC). Early and accurate assessment of rapid remission based on conventional therapy via abdominal computed tomography (CT) images has rarely been investigated. This study aimed to build a prediction model using CT-based body composition parameters for UC risk stratification.

Insights from CMIP6 SSP scenarios for future characteristics of propagation from meteorological drought to hydrological drought in the Pearl River Basin.

Drought is a common and widely distributed natural hazard. Analyzing and predicting drought characteristics and propagation are important for the early warning, prevention, and mitigation of drought disasters. This study used the precipitation and runoff outputs from General Circulation Models (GCMs) of Coupled Model Intercomparison Project Phase 6 (CMIP6) to evaluate the meteorological drought (MD) and hydrological drought (HD) characteristics in the Pearl River Basin (PRB) under two Shared Socioeconomic Pathways (SSPs) (i.

Precipitation and vegetation transpiration variations dominate the dynamics of agricultural drought characteristics in China.

Agricultural drought posing a significant threat to agricultural production is subject to the complex influence of ocean, terrestrial and meteorological multi-factors. Nevertheless, which factor dominating the dynamics of agricultural drought characteristics and their dynamic impact remain equivocal. To address this knowledge gap, we used ERA5 soil moisture to calculate the standardized soil moisture index (SSI) to characterize agricultural drought.

Role of BMI in the relationship between dietary inflammatory index and non-alcoholic fatty liver disease: an intermediary analysis.

Objective: Previous studies have indicated that a pro-inflammatory diet is associated with non-alcoholic fatty liver disease (NAFLD), but the role of BMI remains ambiguous. We aim to study the intermediary effect of BMI on the relationship between dietary inflammatory properties and NAFLD.

Methods: A total of 19536 adult participants from the National Health and Nutrition Examination Surveys (NHANES) were included.

Triglyceride glucose index and Atherogenic index of plasma for predicting colorectal neoplasms in patients without cardiovascular diseases.

Background And Aims: Colorectal neoplasms (CRN) include colorectal cancer (CRC) and colorectal adenoma (CRA). The relationship between CRN and triglyceride-glucose (TyG) index or between CRN and atherogenic index of plasma (AIP) is unclear. This study aims to investigate the roles of TyG index and AIP in predicting CRN in people without cardiovascular disease (CVD).

The usefulness of fecal hemoglobin and calprotectin tests in diagnosing significant bowel diseases: a prospective study.

Objectives: Although colonoscopy remains the gold standard for determining bowel diseases, it's invasive and expensive. New non-invasive diagnostic methods are urgently needed as an initial screening modality. We aimed to investigate the value of fecal calprotectin (FC) and fecal immunochemical test (FIT) in differentiation of significant and non- significant bowel diseases.

Composition and diverse differences of intestinal microbiota in ulcerative colitis patients.

Objective: To explore the composition of the intestinal microbiota in ulcerative colitis (UC) patients and to identify differences in the microbiota between patients with active disease and those in remission.

Methods: Between September 2020 and June 2021, we enrolled into our study, and collected stool samples from, patients with active UC or in remission and healthy control subjects. The diagnosis of UC was based on clinical, endoscopic, radiological, and histological findings.

Predictors for malignant potential and deep submucosal invasion in colorectal laterally spreading tumors.

Background: Colorectal laterally spreading tumors (LSTs) with malignant potential require resection by endoscopic submucosal dissection (ESD), but lesions with deep submucosal invasion (SMI) are endoscopically unresectable.

Aim: To investigate the factors associated with high-grade dysplasia (HGD)/carcinoma and deep SMI in colorectal LSTs.

Methods: The endoscopic and histological results of consecutive patients who underwent ESD for colorectal LSTs in our hospital from June 2013 to March 2019 were retrospectively analyzed.

Efficacy, safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants.

A randomized, double-blind, placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine (HRV) against rotavirus gastroenteritis (RVGE). A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV (n ​= ​3200) or placebo (n ​= ​3200) group. All the subjects received three oral doses of vaccine four weeks apart.

Prediction of clinical efficacy of subcutaneous immunotherapy for Artemisia sieversiana pollen allergic rhinitis by serum metabolomics.

Background/purpose: Specific immunotherapy is the only effective etiological treatment for allergic rhinitis, but subcutaneous immunotherapy has a slow onset and poor compliance. Predicting the clinical efficacy of subcutaneous immunotherapy in advance can reduce unnecessary medical costs and resource waste. This study aimed to identify metabolites that could predict the efficacy of subcutaneous immunotherapy on seasonal allergic rhinitis by serum metabolomics.

Disposable versus reusable gastroscopes: a prospective randomized noninferiority trial.

Background And Aims: Disposable gastroscopes have recently been developed to eliminate the risk of infection transmission from contaminated reusable gastroscopes. We compared the performance of disposable and reusable gastroscopes in patients undergoing gastroscopy.

Methods: Patients requiring gastroscopy were randomized to either the disposable or reusable digital gastroscope group.

Assessing the responses of vegetation to meteorological drought and its influencing factors with partial wavelet coherence analysis.

The increase in drought frequency in recent years is considered as an important factor affecting vegetation diversity. Understanding the responses of vegetation dynamics to drought is helpful to reveal the behavioral mechanisms of terrestrial ecosystems and propose effective drought control measures. In this study, long time series of Normalized Difference Vegetation Index (NDVI) and Solar-induced chlorophyll fluorescence (SIF) were used to analyze the vegetation dynamics in the Pearl River Basin (PRB).

Construction of a novel predictive nomogram for difficult procedure of endoscopic submucosal dissection for colorectal neoplasms.

Objectives: To determine the predictors of difficult colorectal endoscopic submucosal dissection (ESD) and to develop a preoperative predictive model for difficult colorectal ESD procedures.

Methods: Colorectal neoplasms intended to be resected by ESD in our center between August 2013 and February 2019 were retrospectively enrolled. An ESD procedure which took more than 30 min, failed to remove the lesions en bloc or converted to surgery was defined as difficulty.

Prevalence and risk factors of allergic rhinitis and asthma in the southern edge of the plateau grassland region of northern China: A cross-sectional study.

Background: The prevalence rates of allergic rhinitis (AR) and asthma in the border region of China may be different from those in the central region of plateau grasslands. A survey was performed to investigate the prevalence and risk factors for AR, asthma, and AR combined with asthma among adults (age ≥ 20 years) residing in the southern border of plateau grasslands in northern China.

Methods: From May to August 2018, a cross-sectional survey was completed by subjects that were selected using a cluster random sampling method.

Serum Uric Acid Is a Mediator of the Association Between Obesity and Incident Nonalcoholic Fatty Liver Disease: A Prospective Cohort Study.

Objective: Obesity has been demonstrated to show a consistent link with the increased possibility of nonalcoholic fatty liver disease (NAFLD). Since both serum uric acid (SUA) and obesity are essential components of metabolic syndrome (MetS), it is uncertain whether the incidence of NAFLD results from serum uric acid, obesity, or other potential factors based on previous studies.

Patients And Methods: This study enrolled 16,839 participants with no history of alcohol consumption and no fatty liver disease in 2010.

Aberrant expression of mA mRNA methylation regulators in colorectal adenoma and adenocarcinoma.

Background: As the most prevalent post-transcriptional mRNA modification in eukaryotes, N6-Methyladenosine (mA) is closely linked to the occurrence and development of colorectal cancer (CRC). However, there is no systematic evaluation of the expression of mA regulatory genes in CRC.

Methods: By analyzing the TCGA database, we identified METTL3, YTHDF1, IGF2BP1, IGF2BP3, EIF3B, HNRNPA2B1 as overexpressed mA regulators in CRC.

Design and verification of individualized follow-up strategy of colonoscopy for postoperative patients with colorectal cancer.

Background: Current guidelines do not establish an individual scheme for surveillance colonoscopy in postoperative colorectal cancer (CRC) patients.

Aims: The purpose of the study was to screen possible risk factors for the development of metachronous adenoma in postoperative CRC patients and to develop a risk prediction model and verify it.

Methods: Consecutive postoperative patients with CRC were enrolled from April 2007 to December 2013 as the derivation group.