Publications by authors named "Haiyu Shi"
Article Synopsis
- * The hydrogel not only self-diagnoses rehemorrhage by capturing Hb but also gradually releases the drug deferoxamine (DFO), which helps protect nerve cells from damage.
- * Testing in a model showed that the hydrogel significantly improved iron absorption efficiency and reduced hematoma size, suggesting its potential to improve outcomes for patients after hemorrhage surgery.
Constant oxidative stress and lactate accumulation are two main causes of tumor immunosuppression, their concurrent reduction plays a dominant role in effective antitumor immunity, but remains challenging. Herein, reactive oxygen species (ROS) responsive prodrug nanoparticles (designed as DHCRJ) are constructed for metabolic amplified chemo-immunotherapy against triple-negative breast cancer (TNBC) by modulating oxidative state and hyperglycolysis. Specifically, DHCRJ is prepared by the self-assembly of DOX prodrug-tethered ROS consuming bond-bridged copolymers with the loading of bromodomain-containing protein 4 inhibitor (BRD4i) JQ1.
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