Identification and validation of leukemia inhibitory factor as a protective factor in ischemic acute kidney injury.

Background: Ischemia-reperfusion injury (IRI) is a common pathophysiological mechanism of acute kidney injury (AKI). There is an urgent need for a more comprehensive analysis of its underlying mechanisms.

Materials And Methods: The RNA-sequencing dataset GSE153625 was used to examine differentially expressed genes (DEGs) of kidney tissues in IRI-AKI mice compared with sham mice.

[Significance of calcineurin activation and CD40L expression in patients with active lupus nephritis].

Aim: To investigate the significance of the calcineurin (CaN) activation in active lupus nephritis patient.

Methods: Peripheral blood mononuclear cells (PBMCs) were separated from twenty-one active LN patients and 12 healthy controls. Phosphatase activity of CaN was determined using the CaN assay kit by measuring the content of released PO4.