Olfactory bulb microglia activation mediates neuronal pyroptosis in ozone-exposed mice with olfactory and cognitive dysfunction.

In recent years, there has been a notable increase in the concentration of air pollutants in the troposphere, especially ozone. However, limited research has gone beyond examining histopathological alterations in the olfactory bulb (OB) to explore the effects of ozone exposure on olfactory and cognitive functions. In our study, we exposed nine-month-old C57BL/6 mice to ozone at a concentration of 1.

Characterisation of ginsenosides composition in processed American ginseng products using UPLC-MS coupled with chemometric analysis.

American ginseng( L.), a traditional herbal extensively utilised in China, exhibits both medicinal and food properties. Diverse processing American ginseng gain extensive utilisation in China.

Olanzapine enhances early brain maturation through activation of the NODAL/FOXH1 axis.

The portrayed effects of olanzapine on brain development and neuronal response remain unclear under the genetic background of . Here, we constructed therapeutic-dosage olanzapine-treated cerebral organoid (CO) models using induced pluripotent stem cells from human samples. We found that the activation of NODAL/FOXH1 axis mediated the early response to olanzapine up to day 15, which subsequently caused thicker cortical-like structures, cell identity maturation, higher stemness of neural progenitor cells (NPCs), and mature neuronal firing of early neurons in day 24.

Preparation and application of alkali-activated cementitious materials in solidification/stabilization of chromite ore processing residue.

Chromite ore processing residue (COPR) is a typical hazardous waste, which contains Cr(vi) and poses a great threat to the ecological environment and human health. In this study, solidification/stabilization (S/S) of COPR was carried out by using blast furnace slag (BFS) and fly ash (FA) to prepare alkali-activated cementitious materials (AACM). The influence of different factors (water glass modulus, liquid-solid ratio, alkali-solid content and curing temperature) on compressive strength was investigated by single-factor experiment.

Safe Trajectory Planning for Incremental Robots Based on a Spatiotemporal Variable-Step-Size A* Algorithm.

In this paper, a planning method based on the spatiotemporal variable-step-size A* algorithm is proposed to address the problem of safe trajectory planning for incremental, wheeled, mobile robots in complex motion scenarios with multiple robots. After constructing the known conditions, the spatiotemporal variable-step-size A* algorithm is first used to perform a collision-avoiding initial spatiotemporal trajectory search, and a variable time step is utilized to ensure that the robot completes the search at the target speed. Subsequently, the trajectory is instantiated using B-spline curves in a numerical optimization considering constraints to generate the final smooth trajectory.

Comparison of Long-Term Clinical Outcomes and Costs Between Transesophageal Echocardiography-Guided and X-ray-Guided Percutaneous Atrial Septal Defect Closure in Children.

This study aimed to compare the long-term clinical outcomes and costs between using either transesophageal echocardiography (TEE) or X-ray fluoroscopy for Percutaneous atrial septal defect (ASD) closure in children. An analysis was conducted on clinical data from children undergoing TEE-guided (n = 168) and X-ray-guided (n = 139) percutaneous ASD closure. Demographic characteristics, technical indices, acute complications, follow-up outcomes, and costs were compared between the groups.

Association among abnormal glycolipids, reproductive hormones, and cognitive dysfunction in female patients with bipolar disorder.

Background: Patients with bipolar disorder (BD) show abnormalities in glucolipid metabolism and reproductive hormone levels, which are of concern in women with BD. This study was dedicated to investigating the glucolipid and reproductive hormone levels of female patients, and to preliminarily investigating their relationships with cognition.

Methods: A total of 58 unmedicated female BD patients, 61 stable-medicated female BD patients, and 63 healthy controls (HC) were recruited in this study.

Research on the environmental stability performance of chromite ore processing residue solidified products.

Chromite ore processing residue (COPR) is a hazardous waste because of leachable chromium, especially Cr(vi). Therefore, ascorbic acid (AA) and blast furnace slag (BFS) have been used to detoxify and solidify COPR. On this basis, environmental stability experiments with high temperature and freeze-thaw cycles were carried out to explore the stability performance of a solidified body with 40% COPR.

Polystyrene nanoplastics-induced lung apoptosis and ferroptosis via ROS-dependent endoplasmic reticulum stress.

It has been shown that exposure to nanoplastics (MNPs) through inhalation can induce pulmonary toxicity, but the toxicological mechanism of MNPs on the respiratory system remains unclear. Therefore, we explored the toxicological mechanism of exposure to polystyrene nanoplastics (PS-NPs) (0.05, 0.

The complete chloroplast genome sequence of Nepeta bracteata and comparison with congeneric species.

Nepeta bracteata (N. bracteata) is an important medicinal plant used by Chinese ethnic minorities. However, the lack of knowledge regarding the chloroplast genome of N.

Research on an Adaptive Method for the Angle Calibration of Roadside LiDAR Point Clouds.

Light Detection and Ranging (LiDAR), a laser-based technology for environmental perception, finds extensive applications in intelligent transportation. Deployed on roadsides, it provides real-time global traffic data, supporting road safety and research. To overcome accuracy issues arising from sensor misalignment and to facilitate multi-sensor fusion, this paper proposes an adaptive calibration method.

Cadmium-induced pyroptosis is mediated by PERK/TXNIP/NLRP3 signaling in SH-SY5Y cells.

Cadmium (Cd) is a hypertoxic heavy metal that may be exposed to environmental pollutants by humans and animals. It can lead to cognitive disfunction, and is linked to neurodegenerative diseases. Cadmium reportedly can induce endoplasmic reticulum (ER) stress, but few studies have concentrated on it in nerve cells, and the connection between ER stress and neuroinflammation.

Global burden of rheumatic heart disease and its association with socioeconomic development status, 1990-2019.

Aims: Rheumatic heart disease (RHD) remains an important health issue, yet global attention to RHD is diminishing. This study aimed to investigate the global burden of RHD and its relationship with socioeconomic development status.

Methods And Results: Data were obtained from the Global Burden of Disease (GBD) 2019 database.

Human bone marrow mesenchymal stem cells-derived exosomes attenuated prostate cancer progression via the miR-99b-5p/IGF1R axis.

MicroRNA-99b-5p (miR-99b-5p) has been shown to be enriched in serum exosomes of prostate cancer (PCa) patients treated with radiotherapy, while its function in PCa progression remains unclear. The expression levels of miR-99b-5p in PCa tissues, cancer cell lines and human bone marrow mesenchymal stem cells (HBMSCs), as well as HBMSCs-derived exosomes were assessed by quantitative real-time PCR (qRT-PCR). MiR-99b-5p mimics or inhibitor was transfected into HBMSCs, and HBMSCs-derived exosomes with abnormal expression of miR-99b-5p were used to stimulate PCa cell-line LNCaP cells.

The effectiveness of humanoid diagram teaching strategy on care capacity and retention in novice nurses.

Aim: To examine the effectiveness of a Humanoid Diagram Teaching Strategy (HDTS) on care capabilities and retention of novice nurses.

Background: Guiding novice nurses in clinical practice is a matter of concern and the use of diagrams in assisting the learning process and to promote learning efficiency has been acknowledged.

Design: This is a quasi-experimental study with asynchronous repeated measurements for the experimental and control groups.

Risk factors of postoperative acute kidney injury in patients with complex congenital heart disease and significance of early detection of serum transcription factor Nkx2.5.

Objective: This study was designed to investigate the risk factors of postoperative acute kidney injury (AKI) in patients with complex congenital heart disease (CHD) and the significance of early detection of serum transcription factor Nkx2.5.

Methods: A total of 121 CHD patients admitted to the Shengli Clinical Medical College of Fujian Medical University were selected as study participants, among whom 69 patients with AKI after cardiac surgery were set as the research group (RG), and the rest of the 52 patients without AKI were set as the control group (CG).

Evaluation of resource and energy utilization, environmental and economic benefits of rice water-saving irrigation technologies in a rice-wheat rotation system.

Currently, numerous challenges such as excessive irrigation water consumption, labor shortage, lower economic and environmental benefits pose serious threats to rice cultivation systems. Therefore, more water- and labor-efficient irrigation technologies are needed in rice production for minimal environmental hazards and greater economic benefits. After the screening experiment of water-saving cultivation technologies and cultivars, a two-year field experiment was conducted to further explore the effects of efficient water-saving technologies and rice cultivars on the comprehensive benefits, global warming potential (GWP), grain yield, economic benefits, water productivity, nitrogen partial factor productivity, radiation, accumulated temperature and energy use efficiency (EUE) of a rice-wheat rotation system.

Uni-Port Total Thoracoscopic Surgery Versus Median Sternotomy for Redo Tricuspid Valve Replacement: A Retrospective Study.

Background: This study compared the perioperative and follow-up period data of patients who underwent redo tricuspid valve replacements performed via thoracoscopic surgery or median sternotomy. The purpose was to evaluate the feasibility, safety, and surgical outcomes of redo tricuspid valve replacement via uni-port thoracoscopic surgery.

Methods: Forty-nine patients with severe tricuspid valve regurgitation after left-side valve replacement underwent redo tricuspid valve replacements in our hospital from April 2012 to September 2019.

Metabolomic analysis reveals metabolites and pathways involved in grain quality traits of high-quality rice cultivars under a dry cultivation system.

Dry cultivation of high-yielding or drought-resistant rice cultivars relieves the current pressure on rice cultivation systems. However, the metabolites and metabolic pathways that affect rice quality in high-yield or drought-resistant rice cultivars under dry cultivation have not yet been explored. A field experiment was conducted in 2017 to explore the effects of flooding irrigation (F) and dry cultivation (D) of high-yield and -quality cultivars (Huanghuazhan, HH; Yueyou9113, YY) and a drought-resistant cultivar (Hanyou73, HY) on rice quality traits using metabolomic analysis.

[Ultrasound-guided suprascapular nerve block combined with acupuncture for the treatment of calcified tendinitis of rotator cuff].

Objective: To explore the method and effect of ultrasound-guided suprascapular nerve block combined with acupuncture in the treatment of calcified tendinitis of rotator cuff.

Methods: From January 2015 to December 2017, total 30 patients with calcified tendinitis, including 23 cases of supraspinatus tendon, 5 cases of infraspinatus tendon and 2 cases of subscapular tendon, were treated with ultrasound-guided suprascapular nerve block combined with acupuncture. There were 7 males and 23 females, ranging in age from 36 to 71 years old, with an average of 51.

The Effect of Auricular Plaster Therapy on Insomnia in Patients with Rheumatoid Arthritis.

This research was conducted to observe the effects of auricular plaster therapy on insomnia in patients with rheumatoid arthritis (RA). This study involved 76 patients with insomnia caused by RA, who were admitted to Foshan Chancheng Central Hospital-in Foshan, Guangdong, China-from August 2017 to August 2018. The patients were randomized, with 38 to the intervention group and another 38 to the control group.

Original Research: Establishment of an early embolus-related cerebral injury model after cardiopulmonary bypass in miniature pigs.

Embolus-related cerebral injury is still a serious adverse event after cardiopulmonary bypass (CPB). But there is no stable animal model for basic and clinical research purposes. We chose miniature pig to establish a stable animal model of embolus-related cerebral injury after CPB and verified the validity of results by correlating the histopathological findings with those of diffusion-weighted magnetic resonance imaging (DW-MRI).

Interstitial photoacoustic sensor for the measurement of tissue temperature during interstitial laser phototherapy.

Photothermal therapy is an effective means to induce tumor cell death, since tumor tissue is more sensitive to temperature increases than normal tissue. Biological responses depend on tissue temperature; target tissue temperature needs to be precisely measured and controlled to achieve desired thermal effects. In this work, a unique photoacoustic (PA) sensor is proposed for temperature measurement during interstitial laser phototherapy.

Optical properties of tissues quantified using morphological granulometry from phase-contrast images of thin tissue samples.

A method combining morphological granulometry with Mie theory to determine optical scattering in biological tissues was proposed. Otsu's method was applied to binarize phase-contrast images. Binary morphological granulometry was used to estimate size density distribution of the tissue samples based on the binary phase-contrast images.

Trace detection of nitro aromatic explosives by highly fluorescent g-C3N4 nanosheets.

Highly fluorescent g-C3N4 nanosheets were facilely fabricated by exfoliating bulk g-C3N4 under ultrasonic irradiation for 1 h. The atomic force microscopy (AFM) image shows that the resultant g-C3N4 nanosheets are ∼6-14 nm thick, and the suspension is stable in air for several weeks. Remarkably, the obtained nanosheets exhibited strong fluorescence with an extremely high quantum yield (QY) up to 32%, and high sensitivity, selectivity, as well as a fast response to nitro aromatic explosives were observed.