The static and dynamic adsorptive performance of a nitrogen and sulfur functionalized 3D chitosan sponge for mercury and its machine learning evaluation.

The use of chitosan-based sponge materials for Hg(II) removal has gained attention recently due to their effectiveness. However, the complex preparation, limited performance, and poor acid resistance remained major drawbacks. Herein, a nitrogen‑sulfur functionalized macroporous chitosan sponge was successfully synthesized via two mild amidation reactions and exhibited abundant interconnected mesopores.

The MoS/rGO embed in macro-porous PAN gel as a novel DGT binding phase for the rapid and accurate detection of trace Hg(II).

The development of binding gels with a fast uptake rate, high capacity, and good selectivity could be beneficial for trace Hg(II) detection based on the DGT technology. In this study, a novel PAN@MoS/rGO-DGT was assembled by using the nanocomposite embedded in polyacrylonitrile membrane (PAN@MoS/rGO) as the binding phase. The interior regular finger-like macropore of the gel provided a convenient channel for the rapid mass diffusion of Hg(II), and the abundant sulfur offered the paramount driving force for trapping Hg(II).

delivery of PBAE/ZIF-8 enhances the sensitivity of colorectal cancer to doxorubicin through sh-LncRNA ASB16-AS1.

The aim of this study is to investigate the impact of sh-LncRNA ASB16-AS1 on doxorubicin (DOX) resistance in colorectal cancer (CRC). First, an study was conducted to investigate the effects of LncRNA ASB16-AS1, miR-185-5p, and TEAD1 on drug resistance in CRC cells. Subsequently, utilizing nanotechnology, poly(beta amino esters) (PBAE)/zeolitic imidazolate framework-8 (ZIF-8)@sh-LncRNA ASB16-AS1 nanoparticles (PZSNP) were synthesized and characterized, evaluating their cellular toxicity and hemolytic activity.

A Novel Frameshift Mutation(:C.337delC) Associated With α-Thalassemia Trait Detected by Next-Generation Sequencing in Southern China.

Here, we report a novel frameshift mutation caused by a single base deletion in exon 3 of the gene (:c.337delC) detected by next-generation sequencing. The proband was a 26-year-old Chinese pregnant woman who originates from Hunan Province.

The adsorption and release mechanism of different aged microplastics toward Hg(II) via batch experiment and the deep learning method.

Aged microplastics are ubiquitous in the aquatic environment, which inevitably accumulate metals, and then alter their migration. Whereas, the synergistic behavior and effect of microplastics and Hg(II) were rarely reported. In this context, the adsorptive behavior of Hg(II) by pristine/aged microplastics involving polystyrene, polyethylene, polylactic acid, and tire microplastics were investigated via kinetic (pseudo-first and second-order dynamics, the internal diffusion model), Langmuir, and Freundlich isothermal models; the adsorption and desorption behavior was also explored under different conditions.

One-step synthesis of thiol-functionalized metal coordination polymers: effective and superfast removal of Hg (II) in the different matrices to ppb level.

The mercury in water bodies has posed a great threat to the environment and humans, and removing mercury and purifying wastewater has become a global environmental issue. Adopting Zn(II) coordination polymers (Zn-CPs) emerged as a new approach, however, the kind of Zn-CPs, which solely consisted of amino groups, exhibited unsatisfactory performance in capturing Hg(II) at a low level and causing the subsequent leaching of Zn(II) after adsorption. In this study, we fabricated the thiol-modified Zn-based coordination polymers (Zn-CPs-SH) through a one-step solvothermal reaction to efficiently capture Hg(II) from wastewater.

A novel therapeutic strategy of combined camrelizumab and apatinib for the treatment of advanced hepatocellular carcinoma.

Methods: 83 patients with hepatocellular carcinoma (HCC) admitted to the interventional oncology department were randomly divided into two groups. Apatinib and camrelizumab were administered to 42 patients in group A, whereas sorafenib was administered to 41 patients in group B for three months. The clinical efficacy was evaluated in terms of objective response rate (ORR), and disease control rate (DCR).

Inter- and intra-rater agreement of interpretation of functional lumen imaging probe in healthy subjects.

Background: The functional lumen imaging probe (FLIP) evaluates esophagogastric junction (EGJ) opening and esophageal contractility. Both post hoc and real-time analyses are possible, but reproducibility and reliability of analysis remain undefined. This study assesses inter- and intra-rater agreement of normative FLIP measurements among novice and experienced users.

Development and validation of the DGT technique using the novel cryogel for measuring dissolved Hg(II) in the estuary.

The complex seawater matrix has significantly influenced the determination of estuarine dissolved Hg(II), hindering its monitoring and risk assessment in maricultural areas. In this work, SiO-SH-DGT assembled by the sulfhydryl-modified silica cryogel (SiO-SH cryogel) as the novel binding phase was developed to tackle this problem. The uniform dispersion of the cryogel into binding gel was advantageous for achieving remarkable and comparable capacity, which endowed the estimated diffusion coefficient (D) to be 1.

[Expression, purification, and characterization of cell-permeable fusion antioxidant enzyme sensitive to matrix metalloproteinases-2/9].

Antioxidant enzymes fused with cell-penetrating peptides could enter cells and protect cells from irradiation damage. However, the unselective transmembrane ability of cell-penetrating peptide may also bring antioxidant enzymes into tumor cells, thus protecting tumor cells and consequently reducing the efficacy of radiotherapy. There are active matrix metalloproteinase (MMP)-2 or MMP-9 in most tumor cellular microenvironments.

Measurement and identification of relative poverty level of pastoral areas: an analysis based on spatial layout.

Pastoral areas are the key difficulty in China's pursuit of common prosperity and a key region for China to build the northern ecological safety barrier and to realize the Two Centenary Goals. It is of great significance to scientifically evaluate the quality of rural life (QRL), measure the relative poverty level (RPL), and identify the relatively poor areas, making it possible to dock poverty elimination with rural revitalization. Based on the socio-economic data of 18 pastoral areas in Inner Mongolia, this paper draws on spatial layout theory to evaluate QRL and measures RPL by the natural breakpoint method and then identifies the relatively poor areas in Inner Mongolia.

Normative values for esophageal functional lumen imaging probe measurements: A meta-analysis.

Background: The functional lumen imaging probe (Endoflip™) is increasingly used for evaluation of patients with esophageal symptoms. To improve the interpretation of Endoflip™ in clinical practice, normative values with appropriate cut-off values are required.

Methods: Original clinical studies describing Endoflip™ use for measurements of esophageal motility in healthy adults were considered.

Influence of Social Support Network and Perceived Social Support on the Subjective Wellbeing of Mothers of Children With Autism Spectrum Disorder.

This study explored the relations between the social support network of mothers of children with autism spectrum disorder (ASD), perceived social support, and their subjective wellbeing. The participants were mothers of children with ASD in Shanghai. Their social support network structure was explored the nomination method.

Influence of Rural Social Capital and Production Mode on the Subjective Well-Being of Farmers and Herdsmen: Empirical Discovery on Farmers and Herdsmen in Inner Mongolia.

Rural areas are crucial to the realization of sustainable development goals (SDGs). Rural social capital is indispensable for these areas to fulfil the SDGs. As China pursues rural revitalization, it is essential to achieve the sustainable development of rural areas within the agropastoral transition zone (APTZ) in northern China.

NAVIGATE 24-Month Results: Electromagnetic Navigation Bronchoscopy for Pulmonary Lesions at 37 Centers in Europe and the United States.

Introduction: Electromagnetic navigation bronchoscopy (ENB) is a minimally invasive, image-guided approach to access lung lesions for biopsy or localization for treatment. However, no studies have reported prospective 24-month follow-up from a large, multinational, generalizable cohort. This study evaluated ENB safety, diagnostic yield, and usage patterns in an unrestricted, real-world observational design.

Pollution and ecological risk assessment, and source identification of heavy metals in sediment from the Beibu Gulf, South China Sea.

The Beibu Gulf is an important passageway between China and the Association of Southeast Asian Nations, where there has been an increase in pollution of heavy metals (HMs). High concentrations of Pb, Cr, Cd, Cu, Zn, As, and Hg in surface sediment were found in Qinzhou Bay, Fangchenggang, and other coastal areas. Stochastic geo-accumulation analyses identified the pollution to be "uncontaminated"; however, it had an 18% probability of deterioration.

Stable FeO submicrospheres with SiO coating for heterogeneous Fenton-like reaction at alkaline condition.

In the traditional Fenton process, the efficient generation of hydroxyl radical (HO) strongly relies on an acidic circumstance and the iron ions would precipitate and form large amounts of hazardous iron-containing sludge at alkaline pH. To realize stable heterogeneous Fenton-like catalytic degradation at alkaline condition, FeO submicrospheres with SiO coating were successfully synthesized by using water glass as the silica sources via a facile ultrasound assisted method. The as-obtained FeO@SiO spheres were further used as catalysts for the Fenton-like degradation of tetracycline hydrochloride (TC).

The Impact of Biopsy Tool Choice and Rapid On-Site Evaluation on Diagnostic Accuracy for Malignant Lesions in the Prospective: Multicenter NAVIGATE Study.

Background: The diagnostic yield of electromagnetic navigation bronchoscopy (ENB) is impacted by biopsy tool strategy and rapid on-site evaluation (ROSE) use. This analysis evaluates usage patterns, accuracy, and safety of tool strategy and ROSE in a multicenter study.

Methods: NAVIGATE (NCT02410837) evaluates ENB using the superDimension navigation system (versions 6.

Programmed responses of different life-stages of the seagrass Ruppia sinensis to copper and cadmium exposure.

Seagrass meadows are recognized as crucial and are among the most vulnerable habitats worldwide. The aquatic plant genus Ruppia is tolerant of a wide salinity range, and high concentrations of trace metals. However, the tolerance of its early life stages to such trace metal exposure is unclear.

Langerhans cell histiocytosis: A rare aetiology for fetal pleural effusion.

Objective: We present fetal pleural effusions associated with Langerhans cell histiocytosis (LCH).

Case Report: We report a case of fetal pleural effusion in late pregnancy. Due to developing rapidly over short period of time, the baby was delivered by caesarean section at 34 weeks gestation.

Jiawei Shengmai San herbal formula ameliorates diabetic associate cognitive decline by modulating AKT and CREB in rats.

Memory loss is a complication of diabetes which requires new approaches to its treatment. Shengmai San (SMS) is a famous traditional Chinese formula containing Panax ginseng, Ophiopogon japonicas, and Schisandra chinensis, whereas Radix puerariae has many reported pharmacological uses. In this study the combination, as Jiawei SMS (J-SMS) was screened for its ability to reverse diabetes-associated cognitive decline in rats.

Development of fundamental power couplers for 166.6 MHz superconducting quarter-wave beta = 1 proof-of-principle cavities.

Superconducting 166.6 MHz β = 1 cavities of quarter-wave geometry have been chosen for a high energy photon source, a 6 GeV diffraction-limited synchrotron light source currently under construction in Beijing. Five cavities will provide the required 5.

Development and vertical tests of a 166.6 MHz proof-of-principle superconducting quarter-wave beta = 1 cavity.

A low-frequency superconducting cavity is needed in main accelerators for storage ring light sources with ultralow emittance. A compact 166.6 MHz superconducting proof-of-principle cavity was designed adopting a quarter-wave β = 1 geometry for a High Energy Photon Source (HEPS).

Time-dependent impairments in learning and memory in Streptozotocin-induced hyperglycemic rats.

The sedentary lifestyle is responsible for the high prevalence of diabetes which also impairs cognition including learning and memory. Various studies have highlighted the learning and memory impairments in rodent models but data regarding the timeline of their development and their correlation to biochemical parameters are scarce. So, the present study was designed to investigate the type of memory which is more susceptible to hyperglycemia and its correlation with biochemical parameters such as inflammatory cytokines, cAMP response element binding (CREB) and protein kinase B (Akt) activation.