Characteristics, Outcomes and Factors for Place of Death in Patients Admitted to Community-Based Palliative Care Services in Shanghai China: A Multicenter Retrospective Cohort Study.

Background: Community-based palliative care (CBPC) is only available in large cities in mainland China and little is known about who utilizes it.

Objectives: This study examined the characteristics, outcomes, and factors associated with place of death (PoD) among inpatient CBPC patients.

Design: This was a multicenter retrospective cohort study.

Role of subduction dynamics on the unevenly distributed volcanism at the Middle American subduction system.

A typical subduction of an oceanic plate beneath a continent is expected to be accompanied by arc volcanoes along the convergent margin. However, subduction of the Cocos plate at the Middle American subduction system has resulted in an uneven distribution of magmatism/volcanism along strike. Here we construct a new three-dimensional shear-wave velocity model of the entire Middle American subduction system, using full-wave ambient noise tomography.

AGO2a but not AGO2b mediates antiviral defense against infection of wild-type cucumber mosaic virus in tomato.

Evolutionarily conserved antiviral RNA interference (RNAi) mediates a primary antiviral innate immunity preventing infection of broad-spectrum viruses in plants. However, the detailed mechanism in plants is still largely unknown, especially in important agricultural crops, including tomato. Varieties of pathogenic viruses evolve to possess viral suppressors of RNA silencing (VSRs) to suppress antiviral RNAi in the host.

The key role of crystal boron in enhanced degradation of refractory contaminants using heterogeneous Fe/SPC system.

An origin Fenton-like system was discussed for the abatement of refractory contaminants. Sodium percarbonate (SPC) was utilized as the source of HO and crystal boron (C-boron) was applied to enhance the activation of HO. Under the conditions of 0.

Removal and kinetics of cadmium and copper ion adsorption in aqueous solution by zeolite NaX synthesized from coal gangue.

Zeolite can remove the heavy metals in wastewater, but the removal efficiency was determined by the types of zeolites and the treatment conditions. In this study, a kind of zeolite NaX synthesized from the coal gangue, a by-product of coal production, was used and the removal efficiency of Cd and Cuand the kinetic models were studied. The effects of its dosage, initial pH value of wastewater, and adsorption temperature on its adsorption of heavy metals Cd and Cu in the simulated wastewater were studied through the indoor experiments in laboratory, and the adsorption mechanism was analyzed by the adsorption kinetic model based on its adsorption efficiency and its structures.

Circ_0016760 Serves as a Cancer Promoter in Non-small Cell Lung Cancer Through miR-876-3p/NOVA2 Axis.

Non-small cell lung cancer (NSCLC) is a serious threaten to human health globally. Circular RNAs (circRNAs) were testified to alter the progression of NSCLC. This work intended to investigate the functional role of circ_0016760 in NSCLC development and the potential mechanism.

LYAR Promotes Colorectal Cancer Progression by Upregulating Expression and Fatty Acid Metabolism.

Colorectal cancer (CRC) is a highly malignant tumor associated with poor prognosis, yet the molecular mechanisms are not fully understood. In this study, we showed that LYAR, a nucleolar protein, is expressed at a higher level in CRC tissue than in adjacent normal tissue and that LYAR expression is closely associated with distant CRC metastasis. LYAR not only significantly promotes the migration and invasion of CRC cells , but knockdown (KD) of LYAR in CRC cells also inhibits xenograft tumor metastasis .

Reactive oxygen species generation in FeOCl nanosheets activated peroxymonosulfate system: Radicals and non-radical pathways.

Iron oxychloride (FeOCl) is utilized as a activator of peroxymonosulfate (PMS) for the degradation of paracetamol (APAP) and phenacetin (PNCT) in response to the water pollution by persistent pharmaceuticals. The degradation process was well fitted with a pseudo-first order kinetic pattern, and the excellent catalytic performance towards APAP (100 % removal) and PNCT (86.5 % removal) was obtained in the presence of 0.

Anti-inflammatory drugs degradation during LED-UV photolysis of free chlorine: roles of reactive oxidative species and formation of disinfection by-products.

Light-emitting diode (LED) is environmentally friendly with longer life compared with traditionally mercury lamps. This study investigated the non-steroidal anti-inflammatory drugs (NSAIDs)- phenacetin (PNT) and acetaminophen (ACT)- removal during LED-UV (365 nm) photolysis of free available chlorine (FAC). Degradation of PNT and ACT during LED-UV/FAC treatment at pH 5.

Kinetic mechanism of ozone activated peroxymonosulfate system for enhanced removal of anti-inflammatory drugs.

Peroxymonosulfate (PMS) was employed as an activator of ozone (O) to degrade non-steroidal anti-inflammatory drugs (NSAIDs) (aspirin (ASA) and phenacetin (PNT)) in study. The combination of PMS in O system promoted the O decomposition and NSAIDs removal significantly. O molecule, hydroxyl radical (OH) and sulfate radical (SO) were responsible for the removal of target pollutants in O/PMS system.

Measurement of dilation pulses using a pulse-dilation framing camera.

A pulse-dilation framing camera (PFC) and its working principle are introduced. The influence of the dilation pulse on the exposure time is discussed. The measurement of the dilation pulse using the PFC are theoretically analyzed and experimentally verified.

Facile synthesis of 3D silk fibroin scaffolds with tunable properties for regenerative medicine.

Silk fibroin (SF) porous scaffolds provide mechanical support and biochemical signals to encourage cell attachment and modify biological performance. The available methods for the preparation of SF scaffolds are still required. The crosslinkers used are likely to impact the biocompatibility.

Improving the consolidation properties of hydrophilic polyurethane for feldspathic sandstone water erosion prevention.

Feldspathic sandstone is a type of sandstone that is severely eroded by wind, rainfall, and gravity forces. The land surface in feldspathic area is degraded and covered with extremely low vegetation coverage. In this study, we propose a type of hydrophilic polyurethane (W-OH) to control its erosion and conduct the experiment to evaluate the consolidation performances.

Effects of rainfall intensity, slope angle, and vegetation coverage on the erosion characteristics of Pisha sandstone slopes under simulated rainfall conditions.

The water loss and soil erosion in the Pisha sandstone region in the middle reaches of the Yellow River are extremely severe, leading to extremely harmful effects on the ecological environment and safety of the lower reaches. In this paper, the effects of the slope angle (20, 30, and 40°), rainfall intensity (20, 50, and 80 mm/h), and vegetation coverage (10, 30, and 50%) on the erosion characteristics of the Pisha sandstone slopes are studied using indoor-simulated rainfall tests. The results show that the infiltration into the Pisha sandstone is only 10~15%.

Discovery of chalcone-modified estradiol analogs as antitumour agents that Inhibit tumour angiogenesis and epithelial to mesenchymal transition.

Angiogenesis plays an essential role in tumourigenesis and tumour progression, and anti-angiogenesis therapies have shown promising antitumour effects in solid tumours. 2-Methoxyestradiol (2ME2), an endogenous metabolite of estradiol, has been regarded as a potential antitumour agent mainly targeting angiogenesis. Here we synthesized a novel series of chalcones based on 2-methoxyestradiol and evaluated their potential activities against tumours.

LncRNA UCA1 sponges miR-26a to regulate the migration and proliferation of vascular smooth muscle cells.

Background: Recent studies have shown that the long non-coding RNA urothelial carcinoma-associated (UCA1) plays a key role in cardiovascular injury. However, the potential biological role of UCA1 in progression of atherosclerosis (AS) remains unclear. The aim of the present study is to identify the regulation of lncRNA UCA1 on atherosclerosis-related vascular dysfunction via miR-26a targeting phosphatase and tensin homolog (PTEN), and investigate the underlying mechanisms in the development of atherosclerosis.

Long non-coding RNA LINC00339 facilitates the tumorigenesis of non-small cell lung cancer by sponging miR-145 through targeting FOXM1.

Non-small cell lung cancer (NSCLC) is one of leading causes of cancer-related death worldwide. Long noncoding RNAs (lncRNAs) has been identified to modulate the tumorigenesis of NSCLC. However, the precise molecular mechanism of lncRNAs in the course is still unclear.

Effects of intravenous anesthetics on the phosphorylation of cAMP response element‑binding protein in hippocampal slices of adult mice.

cAMP response‑element binding protein (CREB) functions in hippocampal synaptic plasticity and memory formation. However, it remains unknown whether intravenous anesthetics modulate CREB. The present study aimed to examine the effects of intravenous anesthetics on CREB phosphorylation in the mouse hippocampus.

Three-dimensional variations of the slab geometry correlate with earthquake distributions at the Cascadia subduction system.

Significant along-strike variations of seismicity are observed at subduction zones, which are strongly influenced by physical properties of the plate interface and rheology of the crust and mantle lithosphere. However, the role of the oceanic side of the plate boundary on seismicity is poorly understood due to the lack of offshore instrumentations. Here tomographic results of the Cascadia subduction system, resolved with full-wave ambient noise simulation and inversion by integrating dense offshore and onshore seismic datasets, show significant variations of the oceanic lithosphere along strike and down dip from spreading centers to subduction.

Combination therapy of hTERTR and FAM96A for hepatocellular carcinoma through enhancing apoptosis sensitivity.

Avoidance of apoptosis induced by anticancer drugs is an essential factor of carcinogenesis and a hallmark of resistance to cancer therapy. Human telomerase reverse transcriptase receptor (hTERTR) is a potential anti-cancer agent for inhibiting tumor growth. Family with sequence similarity 96 member A (FAM96A) is a ubiquitous, conserved protein and possesses apoptosome-activating and pro-apoptotic tumor suppressor potential in hepatocellular carcinoma (HCC).

Anesthetics inhibit extracellular signal-regulated Kinase1/2 phosphorylation via NMDA receptor, phospholipase C and protein kinase C in mouse hippocampal slices.

Background: Extracellular signal-regulated kinase 1/2 (ERK1/2) has been implicated in learning and memory; however, whether intravenous anesthetics modulate ERK1/2 remains unknown. The aim of this study was to examine the effect of several intravenous anesthetics on the phosphorylation of ERK1/2 in the hippocampus of adult mice.

Methods: Western blotting was used to examine cellular levels of phosphorylated and unphosphorylated ERK1/2 in mouse hippocampus slices, which were incubated with or without anesthetics including propofol, etomidate, ketamine and midazolam, a protein kinase C (PKC) activator or inhibitor, or phospholipase C (PLC) activator or inhibitor.

[Characteristics and contribution of the strengthening units of composite constructed wetland for treating urban sewage].

There are some defects in constructed wetland, including the uneven distribution of flow, easily blocked, lack of oxygen supply systems and the unsatisfactory phosphorus adsorption capacity of the substrates, etc. The research mainly studied the function and contribution of the pool of hydrolysis acidification, the natural reoxygenation/sinking device and strengthen slot for reducing nitrogen and phosphorus. The results showed the removal efficiency of COD and SS in hydrolysis-acidification pool accounted for 38.

Effect of chlorine content of chlorophenols on their adsorption by mesoporous SBA-15.

Studies on the effect of the chlorine content of chlorophenols (CPs) on their adsorption from aqueous solution by mesoporous SBA-15 are important in understanding the mechanisms of CP adsorption. In this study, three CPs with different degrees of chlorine content (i.e.