Podocarpusflavone A inhibits cell growth of skin cutaneous melanoma by suppressing STAT3 signaling.

Background: JAK2/STAT3 pathway is involved in the development and progression of melanoma once DNA damage is caused by environment and genetic factors.

Objective: Here, we aimed to identify novel inhibitor of JAK2/STAT3 pathway and reveal the underlying mechanisms.

Methods: Eighty MedChemExpress compounds were screened by using STAT3-Luc reporter in A375 cells.

Long noncoding RNA NEAT1-modulated miR-506 regulates gastric cancer development through targeting STAT3.

Accumulating evidence has indicated that long noncoding RNA NEAT1 exerts critical roles in cancers. So far, the detailed biological role and mechanisms of NEAT1, which are responsible for human gastric cancer (GC), are still largely unknown. Here, we observed that NEAT1 and STAT3 expressions were significantly upregulated in human GC cells including BGC823, SGC-7901, AGS, MGC803, and MKN28 cells compared with normal gastric epithelial cells GES-1, while miR-506 was downregulated.