Immunomodulatory and osteogenic effects of chitosan-based injectable hydrogel with geniposide-loaded mesoporous bioactive glass.

The immune response dominated by macrophages plays a pivotal role in the regeneration of bone tissue. In this work, an injectable temperature-responsive hydrogel composed of geniposide-loaded mesoporous bioactive glass, chitosan and β-glycerophosphate (G-M Gel) was prepared, showing robustly networks, uniform pore structure, excellent biocompatibility, immunomodulatory effect and osteogenic potential. In an inflammatory microenvironment elicited by lipopolysaccharide (LPS), the proportion of M1 and M2 macrophages measured by flow cytometry were 33.

Alginate-modified ZnO anti-planktonic and anti-biofilm nanoparticles for infected wound healing.

Bacterial infections is one of the main factors delaying the wound healing, which has become a serious challenge for healthcare systems. Zinc oxide nanoparticles (ZnO NPs), which show broad-spectrum and excellent antibacterial activity, tend to aggregate easily and therefore hardly penetrate into bacterial biofilms, showing limited anti-biofilm properties. Herein，alginate (ALG) modified ZnO NPs (ZnO@ALG) were prepared via the combination of mussel-inspired method and "thiol-Michael" click reaction, which showed excellent dispersion and biocompatibility.

Fault diagnosis method for oil-immersed transformers integrated digital twin model.

To address the problems of low accuracy in fault diagnosis of oil-immersed transformers, poor state perception ability and real-time collaboration during diagnosis feedback, a fault diagnosis method for transformers based on the integration of digital twins is proposed. Firstly, fault sample balance is achieved through Iterative Nearest Neighbor Oversampling (INNOS), Secondly, nine-dimensional ratio features are extracted, and the correlation between dissolved gases in oil and fault types is established. Then, sparse principal component analysis (SPCA) is used for feature fusion and dimensionality reduction.

Autoimmune encephalitis followed by hemophagocytic lymph histiocytosis: a case report.

Objective: This study aims to report three cases of autoimmune encephalitis followed by hemophagocytic lymphohistiocytosis.

Methods: Data of relevant patients treated between 2019 and 2022 were retrospectively collected from the Department of Neurology at the Second Affiliated Hospital of Guangzhou Medical University.

Results: The age at onset of the three patients was 37, 63, and 36 years, respectively.

Gold Nanoparticles Confined in Mesoporous Bioactive Glass for Periodontitis Therapy.

Periodontitis is a chronic disease caused by bacterial infection and is characterized with alveolar bone resorption. Bone regeneration in periodontitis remains a critical challenge because bacterial infection induced an unfavorable microenvironment for osteogenesis. Therefore, it is necessary to design proper therapeutic platforms to control bacterial infection and promote bone regeneration.

Transformer fault diagnosis method based on SMOTE and NGO-GBDT.

In order to improve the accuracy of transformer fault diagnosis and improve the influence of unbalanced samples on the low accuracy of model identification caused by insufficient model training, this paper proposes a transformer fault diagnosis method based on SMOTE and NGO-GBDT. Firstly, the Synthetic Minority Over-sampling Technique (SMOTE) was used to expand the minority samples. Secondly, the non-coding ratio method was used to construct multi-dimensional feature parameters, and the Light Gradient Boosting Machine (LightGBM) feature optimization strategy was introduced to screen the optimal feature subset.

Facilitators and barriers to the implementation of dietary nutrition interventions for community-dwelling older adults with physical frailty and sarcopenia: A qualitative meta-synthesis.

Objectives: With the acceleration of an aging society, the prevalence of age-related chronic diseases such as physical frailty and sarcopenia is gradually increasing with numerous adverse effects. Dietary nutrition is an important modifiable risk factor for the management of physical frailty and sarcopenia, but there are many complex influences on its implementation in community settings. This study aimed to summarize the facilitators and barriers to the implementation of dietary nutrition interventions for community-dwelling older adults with physical frailty and sarcopenia, and to provide a reference for the formulation of relevant health management programs.

The Complete Mitochondrial Genome and Phylogenetic Analysis of the Freshwater Shellfish (Bivalvia: Pharidae).

Razor clams, belonging to the Pharidae and Solenidae families, are ecologically and economically important; however, very little research has been conducted on the Pharidae family. The genus is a marine-derived freshwater lineage, and is a rare freshwater species of the Pharidae family. In order to understand the phylogenetic relationships of , we sequenced the mitochondrial genome of the genus , which is 16,262 bp in length and consists of 12 protein-coding genes (PCGs), 22 transfer RNA genes (tRNAs), and 2 ribosomal RNA genes (rRNAs).

Optimized scheduling study of user side energy storage in cloud energy storage model.

With the new round of power system reform, energy storage, as a part of power system frequency regulation and peaking, is an indispensable part of the reform. Among them, user-side small energy storage devices have the advantages of small size, flexible use and convenient application, but present decentralized characteristics in space. Therefore, the optimal allocation of small energy storage resources and the reduction of operating costs are urgent problems to be solved.

Brain radial enhancement pattern in patients with negative glial fibrillary acidic protein-IgG: A cases series study.

Background And Objectives: Brain radial enhancement pattern on magnetic resonance imaging (MRI) has been identified as typical lesions in autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A). However, the authors encountered several patients without GFAP-IgG showing that such specific imaging. In the present study, we reported the clinical pictures of 5 GFAP-IgG-negative patients with GFAP-A specific imaging pattern.

Gelatin-Functionalized Carbon Nanotubes Loaded with Cisplatin for Anti-Cancer Therapy.

Cisplatin (Cp), a chemotherapeutic agent, interacts with purines on tumor DNA, causing tumor cell apoptosis. However, cisplatin has the characteristics of non-specific distribution and lack of selectivity, resulting in systemic toxicity. Moreover, it cannot maintain the drug's high concentration in the tumor-weak acid environment.

Osteogenic and antibacterial PLLA membrane for bone tissue engineering.

Insufficient bone regeneration and bacterial infection are two major concerns of bone repair materials. Poly-L-lactic acid (PLLA) have been widely used in bone tissue engineering (BTE), however, lack of osteogenic and antibacterial properties have greatly limit its clinical application. Herein, PLLA membrane was firstly treated with polydopamine (PDA), and then modified with ε-polylysine (ε-PL) and alginate (ALG) via layer-by-layer method.

Graphene Oxide/RhPTH(1-34)/Polylactide Composite Nanofibrous Scaffold for Bone Tissue Engineering.

Polylactide (PLA) is one of the most promising polymers that has been widely used for the repair of damaged tissues due to its biocompatibility and biodegradability. PLA composites with multiple properties, such as mechanical properties and osteogenesis, have been widely investigated. Herein, PLA/graphene oxide (GO)/parathyroid hormone (rhPTH(1-34)) nanofiber membranes were prepared using a solution electrospinning method.

Developing a Novel Enamel Adhesive with Amorphous Calcium Phosphate and Silver Nanoparticles to Prevent Demineralization during Orthodontic Treatment.

During fixed orthodontic treatment, white spot lesions are prevalent issues associated with cariogenic bacteria. This study aims to construct an orthodontic adhesive containing nanoparticles of amorphous calcium phosphate-polydopamine-Ag (NPA) fillers to combat white spot lesions. The NPA fillers were prepared and characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS).

Maize (Zea mays L.) responses to salt stress in terms of root anatomy, respiration and antioxidative enzyme activity.

Background: Soil salt stress is a problem in the world, which turns into one of the main limiting factors hindering maize production. Salinity significantly affects root physiological processes in maize plants. There are few studies, however, that analyses the response of maize to salt stress in terms of the development of root anatomy and respiration.

Alginate-modified mesoporous bioactive glass and its drug delivery, bioactivity, and osteogenic properties.

Mesoporous bioactive glass (MBG) is widely used in bone tissue repairing and drug loading. However, burst release of drug and poor compatibility with other materials limited its application. It is an effective way to modify MBG with a polymer brush to improve the properties.

Advanced materials for enamel remineralization.

Dental caries, a chronic and irreversible disease caused by caries-causing bacteria, has been listed as one of the three major human diseases to be prevented and treated. Therefore, it is critical to effectively stop the development of enamel caries. Remineralization treatment can control the progression of caries by inhibiting and reversing enamel demineralization at an early stage.

Functionalization of Electrospun Nanofiber for Bone Tissue Engineering.

Bone-tissue engineering is an alternative treatment for bone defects with great potential in which scaffold is a critical factor to determine the effect of bone regeneration. Electrospun nanofibers are widely used as scaffolds in the biomedical field for their similarity with the structure of the extracellular matrix (ECM). Their unique characteristics are: larger surface areas, porosity and processability; these make them ideal candidates for bone-tissue engineering.

Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: To Identify Its Diagnosis, Management and Prognosis (GFAP-AID) Registry: Study Protocol for an Ambispective, Multicenter Registry in China.

Purpose: Currently, no uniform diagnostic criteria or treatment consensus is available for patients with autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A). The aim of this registry is to develop diagnostic and therapeutic recommendations for GFAP-A based on clinical features, neuroimaging, neuroelectrophysiological examinations, laboratory tests, specific antibody tests, immunotherapy, and prognosis.

Patients And Methods: This multicenter, nationwide ambispective registry includes twenty-seven hospitals in China.

Identifying a novel KLF2/lncRNA SNHG12/miR-494-3p/RAD23B axis in Spare Nerve Injury-induced neuropathic pain.

Spinal cord injury (SCI) is a devastating condition for patients, affecting nearly 2.5 million people globally. Multiple side effects of SCI have resulted in a terrible life experience for SCI patients, of which neuropathic pain has attracted the most scientific interest.

Development of a Nomogram for Predicting Asymptomatic Coronary Artery Disease in Patients with Ischemic Stroke.

Background: Coronary artery stenosis (CAS) ≥50% often coexists in patients with ischemic stroke, which leads to a significant increase in the occurrence of major vascular events after stroke. This study aimed to develop a nomogram for diagnosing the presence of ≥50% asymptomatic CAS in patients with ischemic stroke.

Methods: A primary cohort was established that included 275 non-cardioembolic ischemic stroke patients who were admitted from January 2011 to April 2013 to a teaching hospital in southern China.

A deep adversarial model for segmentation-assisted COVID-19 diagnosis using CT images.

The outbreak of coronavirus disease 2019 (COVID-19) is spreading rapidly around the world, resulting in a global pandemic. Imaging techniques such as computed tomography (CT) play an essential role in the diagnosis and treatment of the disease since lung infection or pneumonia is a common complication. However, training a deep network to learn how to diagnose COVID-19 rapidly and accurately in CT images and segment the infected regions like a radiologist is challenging.

Perceived social support, resilience and health self-efficacy among migrant older adults: A moderated mediation analysis.

Migrant older adults become more disadvantaged in health due to aging and migration-related problems. This study aimed to examine the mediating role of resilience in the relationship between perceived social support and health self-efficacy, and to test whether gender moderated the mediating effect of resilience between perceived social support and health self-efficacy among migrant older adults. A total of 184 migrant older adults were recruited from five communities.

Combination of Mussel Inspired Method and "Thiol-Michael" Click Reaction for Biocompatible Alginate-Modified Carbon Nanotubes.

Carbon nanotubes (CNTs) have attracted great interest in biomedical fields. However, the potential toxicity and poor dispersion of CNTs have greatly limited its application. In this work, a mussel-inspired method combined with the "thiol-Michael" click reaction was used to modify the surface of CNT and improve its properties.