Changing epidemiology of leptospirosis in China from 1955 to 2022.

Background: Leptospirosis, a zoonotic disease caused by pathogenic species of the genus Leptospira, is an important public health concern globally. Leptospirosis has been notifiable under statute in China since 1955, and its epidemiological characteristics have evolved during near 70 years. This study aimed to describe the spatial and temporal patterns and demographic characteristics of leptospirosis from 1955 to 2022 in China, and explore the possible factors that influence leptospirosis transmission risk.

The effects of maternal health literacy, family functioning and self-efficacy on antepartum depression in pregnant women in China: a moderated mediation model.

Background: Antepartum depression (AD) is associated with a greater risk of adverse outcomes for both mothers and fetuses. Maternal health literacy (MHL), family functioning (FF), and self-efficacy (SE) are important factors affecting antepartum depression (AD) in pregnant women. Therefore, this study aimed to explore the associations between these factors and whether MHL and SE mediate the relationship between FF and AD.

The characteristics of intestinal microflora in infants with rotavirus enteritis, changes in microflora before and after treatment and their clinical values.

Rotavirus (RV) is a leading pathogen causing diarrhea in children. In this study, a total of 51 fecal samples from children with RV enteritis, 29 post-treatment fecal samples, and 38 fecal samples from age-matched healthy controls were collected. Microbial DNA was isolated from the samples followed by high throughput Illumina sequencing targeting 16 S rRNA gene.

The formaldehyde stress on photosynthetic efficiency and oxidative stress response of moss L.

Introduction: Formaldehyde is a common gaseous pollutant emitted by buildings and decorative materials. In recent years, growing concerns have been raised regarding its harmful effects on health in indoor air. Therefore, this study aims to investigate the physiological and photosynthetic response mechanisms of under formaldehyde stress.

PAD resin: An intelligent adsorbent for solving Cr(VI) pollution with real-time feedback and high efficiency.

To address the urgent issue of Cr(VI) pollution and protect aquatic ecosystems, we conducted an exhaustive investigation into a Poly(acrylamide-co-methacryloyloxyethyl trimethylammonium chloride) (PAD) resin synthesized through an environmentally friendly aqueous polymerization process. This resin not only boasts a high capacity for Cr(VI) removal but also incorporates a colorimetric sensing mechanism that visually transitions from transparent to yellow upon Cr(VI) adsorption, offering real-time, non-invasive monitoring and optimization of the remediation process. According to the Langmuir model, at a pH of 4.

Redox nanodrugs alleviate chronic kidney disease by reducing inflammation and regulating ROS.

Immune-mediated glomerular diseases lead to chronic kidney disease (CKD), primarily through mechanisms such as immune cell overactivation, mitochondrial dysfunction and imbalance of reactive oxygen species (ROS). We have developed an ultra-small nanodrug composed of MnO nanoparticles which is functionalized with biocompatible ligand citrate (C-MnO NPs) to maintain cellular redox balance in an animal model of oxidative injury. Furthermore, this ultra-small nanodrug, loaded with tacrolimus (Tac), regulated the activity of immune cells.

Construction of a zero-dimensional halide perovskite in micron scale towards a deeper understanding of phase transformation mechanism and fluorescence applications.

Zero-dimensional (0D) halide perovskites have garnered significant interest due to their novel properties in optoelectronic and energy applications. However, the mechanisms underlying their phase transformations and fluorescence properties remain poorly understood. In this study, we have synthesized a micron-scale 0D perovskite observable under confocal laser scanning microscopy (CLSM).

Application of exosomes in tumor immunity: recent progresses.

Exosomes are small extracellular vesicles secreted by cells, ranging in size from 30 to 150 nm. They contain proteins, nucleic acids, lipids, and other bioactive molecules, which play a crucial role in intercellular communication and material transfer. In tumor immunity, exosomes present various functions while the following two are of great importance: regulating the immune response and serving as delivery carriers.

NLRC4 methylation and its response to intravenous immunoglobulin therapy in Kawasaki disease: a case control study.

Background: Kawasaki disease (KD) is a systemic vasculitis accompanied by many systemic physiological and biochemical changes. Elucidating its molecular mechanisms is crucial for diagnosing and developing effective treatments. NLR Family CARD Domain Containing 4 (NLRC4) encodes the key components of inflammasomes that function as pattern recognition receptors.

Bibliometric analysis of transforaminal lumbar interbody fusion: research status, trends, and future directions.

Purpose: Transforaminal lumbar interbody fusion (TLIF) is a classic surgical procedure for posterior lumbar fusion. This study aims to analyze the TLIF field by bibliometric method and comprehensively summarize the research status and trends.

Methods: All TLIF-related articles were retrieved from the Web of Science.

An oil-absorbing resin with a simple polymerization system with benzyl methacrylate as a functional monomer.

To solve the problem of the low absorbency of oil-absorbing resins, oil-absorbing resins (PAMs) were fabricated in this study by introducing commercially available benzyl methacrylate (BZMA) as a functional monomer copolymerized with stearyl methacrylate (SMA) and butyl acrylate (BA). The internal network structure of the PAMs expanded more easily when absorbing oils or organic solvents after introducing rigid groups of the benzene ring by an uncomplex polymerization process, which provided the oil-absorbing resin with good absorbency. The reagents were all commercially available, and there was no other pretreatment or posttreatment process.

Generation and enhancement of the sum sideband under double radiation pressure.

A theoretical scheme to enhance the sum sideband generation (SSG) via double radiation pressure is proposed. In this scheme, both sides of the double-cavity system are driven by red and blue detuned pump lasers and frequency components are generated at the sum sideband through optomechanical nonlinear interaction. The results show that the efficiency of SSG can be improved with orders of magnitude.

An extracellular electron transfer enhanced electrochemiluminescence aptasensor for analysis.

As a crucial indicator in food and water safety testing, the detection of plays a significant role in maintaining environmental sanitation and promoting public health. Herein, based on the electrochemical activity characteristics of , we established an enhanced electrochemiluminescence aptasensor for analysis. This study presents a new method for accurate identification by utilizing a double aptamer recognition system.

Rewiring carbon flow in PCC 6803 for a high rate of CO-to-ethanol under an atmospheric environment.

Cyanobacteria are an excellent microbial photosynthetic platform for sustainable carbon dioxide fixation. One bottleneck to limit its application is that the natural carbon flow pathway almost transfers CO to glycogen/biomass other than designed biofuels such as ethanol. Here, we used engineered sp.

Ecology, invasion history and biodiversity-driven management of the coconut black-headed caterpillar in Asia.

The coconut black-headed caterpillar (BHC), Walker (Lepidoptera: Xyloryctidae) is an important herbivore of palm trees that originates in South Asia. Over the past decades, has spread to several countries in Eastern and Southeast Asia. BHC larval feeding can cause severe defoliation and occasional plant death, resulting in direct production losses (e.

Pharmacokinetic and Target Engagement Measures of ANX007, an Anti-C1q Antibody Fragment, Following Intravitreal Administration in Nonhuman Primates.

Purpose: C1q and the classical complement cascade are key regulators of synaptic pruning, and their aberrant activation has been implicated in neurodegenerative ophthalmic diseases including geographic atrophy and glaucoma. The antigen-binding fragment antibody ANX007 specifically recognizes globular head groups of C1q to block substrate binding and functionally inhibit classical complement cascade activation. ANX007 was assessed in nonclinical studies of biodistribution and C1q target engagement in the eye following intravitreal (IVT) administration in cynomolgus monkeys.

[Clinical and genetic analysis of a child with Culler-Jones syndrome due to variant of GLI2 gene].

Objective: To explore the genetic basis for a child featuring short stature and postaxial polydactyly.

Methods: A child who presented at Ningbo Women & Children's Hospital in May 2021 due to the"discovery of growth retardation for more than two years" was selected as the subject. Peripheral blood samples of the child and his parents were collected for the extraction of genomic DNA.

Stratified assessment and warning regimen for prevention of acute adverse reactions to iodinated contrast media: results of 150,343 cases in a tertiary hospital.

For contrast-enhanced CT examinations, there is a lack of comprehensive optimal management strategies of risk factors to reduce the risk of iodinated contrast media (ICM)-induced acute adverse reactions (AAR). Here, we determine the relationship between the rate of ICM-AAR and a stratified assessment and warning (SAW) regimen, which integrated risk identification, stratification, early warning, and prevention. A total of 120,822 cases in the conventional assessment period (58 years ± 15, 55.

Cuproptosis-associated genes and immune microenvironment characterization in breast cancer.

Excess Cu can cause cell death as a cofactor for essential enzymes. The relationship between cuproptosis-associated genes (CAGs) and breast cancer (BR) is not completely investigated. Here, the transcriptome expression and mutation profile data of BR samples from the Cancer Genome Atlas database were retrieved to identify CAGs.