Comprehensive influence of individualized nutrition support and nursing strategy on rehabilitation of patients with liver cancer after operation.

Background: Hepatocellular carcinoma ranks among the most prevalent malignant neoplasms. Surgical intervention constitutes a critical therapeutic approach for this condition. Nonetheless, postoperative recovery is frequently influenced by the patient's nutritional status and the quality of nursing care provided.

The impact of HBsAg reduction via siRNA treatment on natural and vaccine (BRII-179)-induced HBV-specific humoral and cellular immune responses.

Background And Aims: The impact of HBsAg reduction from small interfering RNA (siRNA) treatments on HBV-specific immunity of CHB participants has not been adequately analyzed in human. We conducted a phase 2a study treating CHB participants with 9 4-weekly doses of HBV-targeted siRNA elebsiran (BRII-835), either alone (n=10) or in combination with a VLP-based therapeutic vaccine (BRII-179) containing Pre-S1, Pre-S2, and S antigens, co-administered with (n=39) or without (n=41) IFNα.

Methods: We analyzed longitudinally for 72 weeks virological, clinical, and immunological parameters including HBsAg, ALT, anti-HBs, the neutralizing activity of representative sera, and frequency and cytokine secretion ability of T cells specific for Pre-S1, Pre-S2, and S both directly ex vivo and after in vitro expansion.

Multi-omics analysis reveals the molecular mechanisms and therapeutic targets in high altitude polycythemia.

Polycythemia, characterized by an abnormal increase in red blood cells, can manifest as primary polycythemia (PV) or secondary polycythemia, often due to conditions like obstructive sleep apnea (OSA) and high-altitude polycythemia (HAP). Understanding the molecular mechanisms underlying these conditions is crucial for developing targeted therapies. Transcriptome analysis was performed to identify differentially expressed genes (DEGs), significant modules, and immune cell infiltration.

NFIX suppresses breast cancer cell proliferation by delaying mitosis through downregulation of CDK1 expression.

One of the fundamental biological characteristics of malignant tumors is their uncontrolled growth and multiplication, which is a major reason why breast cancer remains incurable. The significance of NFIX in the development of various cancers has been demonstrated by an increasing number of studies in recent years. However, the role of NFIX in breast cancer has received less attention.

Mechanical Properties, Corrosion Damage Evolution Laws, and Durability Deterioration Indicators of High-Performance Concrete Exposed to Saline Soil Environment for 8 Years.

Most of the current studies rely on simulated brine corrosion environments and lack long-term investigations into concrete corrosion damage evolution under actual corrosive conditions. In this paper, high-performance concrete (HPC) with various mix ratios is designed in the context of the Qinghai Salt Lake region in China, and the evolution of corrosion damage of HPC with different water-binder ratios (/) and different fly ash (FA) admixtures under long-term field exposure conditions is obtained by testing the ultrasonic velocity and strengths of the HPC in the field exposure of the HPC in the Qinghai Salt Lake region. The results show that the corrosion resistance of HPC is related to its water-binder ratio and mineral admixture type and dosage under the exposure of 8 years in Qinghai Salt Lake area.

The Observation of Meiotic Union Behavior of Gametophytes Provides a New Basis for Ploidy of .

As an important aquaculture fish, the genus Carassius exhibits different ploidy, including tetraploids and hexaploids [...

1α,25(OH)2D3 Regulates the TGF-β1/Samd Signaling Pathway Inhibition of Hepatic Stellate Cell Activation.

To investigate the effect of 1α,25(OH)D on hepatic stellate cells and the mechanism of the TGF-β1/Smad signaling pathway.LX2 cells were treated with TGF-β1 and different concentrations of 1α,25(OH)D. Cell proliferation was assessed using the CCK8 assay to determine the optimal concentration of 1α,25(OH)D activity.

The Clinical Prediction Value of the Ubiquitination Model Reflecting the Microenvironment Infiltration and Drug Sensitivity in Breast Cancer.

The ubiquitin-proteasome system influences cancer progression through multiple mechanisms. Due to the extensive proteasomal modifications observed in cancer tissues, ubiquitination is closely related to various biological functions with cancer. However, the roles of ubiquitin-related genes (UbRGs) in breast cancer (BC) have not been thoroughly investigated.

Exploring the potential association between serum selenium and hypertension in obese adult males in the United States.

Previous studies on the correlation between serum selenium and hypertension have yielded inconsistent results. Our previous analysis of participants from the National Health and Nutrition Examination Survey (NHANES) 2011-2018 indicated that elevated serum selenium concentrations were associated with an increased risk of metabolic abnormalities in obese individuals, with the primary effect being on blood pressure in males. The aim of this study was to further elucidate the relationship between serum selenium and the risk of hypertension in obese males.

Detecting psychometric and diagnostic performance of the RU_SATED v2.0 multidimensional sleep health scale in community-dwelling adults combining exploratory graph analysis and ROC analysis.

Objective: The RU_SATED scale is increasingly used across the globe to measure sleep health. However, there is a lack of consensus around its psychometric and diagnostic performance. We conducted an empirical investigation into the psychometrics of the Chinese version of the RU_SATED (RU_SATED-C) scale, with a focus on structural validity and diagnostic performance.

A cross-sectional study on exposure to secondhand smoke in indoor public places and attitudes of residents towards the smoke control ordinance in public places.

Introduction: Secondhand smoke (SHS) exposure is a serious public health problem. This study aims to collect data on tobacco control since the implementation of the new version of the Smoke Control Ordinance in Public Places of Hangzhou (the Ordinance), combined with questionnaire surveys to understand the SHS exposure situation in public places, relevant knowledge and attitudes of residents in Hangzhou.

Methods: We used data from a population-based tobacco control survey of 2746 adults aged 15-75 years conducted in Hangzhou, Zhejiang Province in March 2023.

Perceived stress mediates the longitudinal effect of sleep quality on internalizing symptoms.

Background: Numerous studies have explored the relationship between sleep quality and internalizing symptoms (i.e., depression and anxiety), but there is uncertainty about their directional pathways.

A longitudinal examination of the measurement properties and invariance of the Sleep Condition Indicator in Chinese healthcare students.

Background: The Sleep Condition Indicator (SCI), an insomnia measurement tool based on the updated Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria with sound psychometric properties when applied in various populations, was evaluated here among healthcare students longitudinally, to demonstrate its measurement properties and invariance in this particularly high-risk population.

Methods: Healthcare students of a Chinese university were recruited into this two-wave longitudinal study, completing the simplified Chinese version of the SCI (SCI-SC), Chinese Regularity, Satisfaction, Alertness, Timing, Efficiency, Duration (RU_SATED-C) scale, Chinese Patient Health Questionnaire-4 (PHQ-4-C), and sociodemographic variables questionnaire (Q-SV) between September and November 2022. Structural validity, measurement invariance (MI), convergent and discriminant validity, internal consistency, and test-retest reliability of the SCI-SC were examined.

Dendritic copper oxide catalyst engineering weak-polarity Cu-O bond for high-efficiency nitrate electroreduction.

Nitrate reduction reaction (NORR) is deemed a promising pathway for both ammonia synthesis and water purification. Developing a high-efficiency catalyst with excellent NH selectivity and catalytic stability is desirable but remains challenging. In this work, a dendritic copper oxide catalyst (Cu-B) has been developed to efficiently catalyze NORR for ammonia production, the Cu-B exhibits excellent catalytic performance, achieving an NH Faradaic efficiency as high as 94 % and an NH yield of 16.