Publications by authors named "Haiya Yu"
Article Synopsis
- - Cardiac fibrosis affects the prognosis for patients after a heart attack (myocardial infarction, MI) and this study investigates the role of the transcription factor Prrx2 in regulating the Wnt5a gene and its impact on fibrosis post-MI.
- - In experiments on mice, increased Prrx2 and Wnt5a expression was linked to higher levels of markers for cell differentiation and fibrosis, but knocking down Prrx2 improved survival and reduced cardiac damage after MI.
- - Prrx2 directly interacts with the Wnt5a gene to enhance its expression, and both Prrx2 and Wnt5a are essential for TGF-β-induced cardiac fibroblast differentiation, suggesting targeting
Traditional Chinese medication is increasingly used to treat a wide range of human chronic diseases like cardiovascular diseases and cancers. This study was designed to explore whether ka-sai-ping (KSP), a novel traditional Chinese medicine developed by us, prevents gastric cancer growths and to investigate the underlying mechanism. The xenograft model of mouse gastric cancer was established by injecting MFCs into nude mouse subcutaneously.
View Article and Find Full Text PDFBackground: Berberine has several preventive effects on cardiovascular diseases. Increased expression of miR-29b has been reported to attenuate cardiac remodeling after myocardial infarction (MI). We hypothesized that berberine via an miR-29b-dependent mechanism promotes angiogenesis and improves heart functions in mice after MI.
View Article and Find Full Text PDFDiabetes is one of high risk factors for cardio- and cerebra-vascular diseases, including stroke, atherosclerosis and hypertension. This study was conducted to elucidate whether and how thromboxane receptor (TPr) activation contributes to blood-brain barrier (BBB) dysfunction in diabetes. Human brain microvascular endothelial cells (HBMECs) were cultured.
View Article and Find Full Text PDFEndothelial dysfunction, which is caused by endothelial nitric oxide synthase (eNOS) uncoupling, is an initial step in atherosclerosis. This study was designed to explore whether Chinese medicine xin-mai-jia (XMJ) recouples eNOS to exert anti-atherosclerotic effects. Pretreatment of XMJ (25, 50, 100 μg/ml) for 30 minutes concentration-dependently activated eNOS, improved cell viabilities, increased NO generations, and reduced ROS productions in human umbilical vein endothelial cells incubated with HO for 2 hours, accompanied with restoration of BH4.
View Article and Find Full Text PDFWe have previously reported that activation of AMP-activated kinase alpha 2 (AMPKα2) by nicotine or angiotensin II (AngII) instigates formation of abdominal aortic aneurysms (AAA) in Apoe-/- mice. Statins, used to treat hyperlipidemia widely, activate AMPK in vascular cells. We sought to examine the effects of pravastatin on AAA formation and uncover the molecular mechanism.
View Article and Find Full Text PDFPrimary Objective: Lipopolysaccharide (LPS) is known to alter the integrity of the blood-brain barrier (BBB) in sepsis, although the underlying mechanism remains unknown. The aim of this study was to elucidate the molecular mechanisms underlying disruption of the BBB in LPS-induced sepsis.
Research Design: Both in vitro and in vivo experiments were designed to test the role of AMP-activated protein kinase (AMPK) in LPS-induced BBB dysfunction.