Chronic NaAsO exposure promotes migration and invasion of prostate cancer cells by Akt/GSK-3β/β-catenin/TCF4 axis-mediated epithelial-mesenchymal transition.

Inorganic arsenic is a Class I human Carcinogen. However, the role of chronic inorganic arsenic exposure on prostate cancer metastasis still unclear. This study aimed to investigate the effects and mechanism of chronic NaAsO exposure on migration and invasion of prostate cancer cells.

Lipopolysaccharide modification enhances the inhibitory effect of clodronate liposomes on hepatic fibrosis by depletion of macrophages and hepatic stellate cells.

Hepatic fibrosis is a complex chronic liver disease in which both macrophages and hepatic stellate cells (HSCs) play important roles. Many studies have shown that clodronate liposomes (CLD-lipos) effectively deplete macrophages. However, no liposomes have been developed that target both HSCs and macrophages.

The signature of cuproptosis-related immune genes predicts the tumor microenvironment and prognosis of prostate adenocarcinoma.

Background: Cuproptosis plays a crucial role in cancer, and different subtypes of cuproptosis have different immune profiles in prostate adenocarcinoma (PRAD). This study aimed to investigate immune genes associated with cuproptosis and develop a risk model to predict prognostic characteristics and chemotherapy/immunotherapy responses of patients with PRAD.

Methods: The CIBERSORT algorithm was used to evaluate the immune and stromal scores of patients with PRAD in The Cancer Genome Atlas (TCGA) cohort.

Vison transformer adapter-based hyperbolic embeddings for multi-lesion segmentation in diabetic retinopathy.

Diabetic Retinopathy (DR) is a major cause of blindness worldwide. Early detection and treatment are crucial to prevent vision loss, making accurate and timely diagnosis critical. Deep learning technology has shown promise in the automated diagnosis of DR, and in particular, multi-lesion segmentation tasks.

TWEAK Signaling-Induced ID1 Expression Drives Malignant Transformation of Hepatic Progenitor Cells During Hepatocarcinogenesis.

The malignant transformation of hepatic progenitor cells (HPCs) in the inflammatory microenvironment is the root cause of hepatocarcinogenesis. However, the potential molecular mechanisms are still elusive. The HPCs subgroup is identified by single-cell RNA (scRNA) sequencing and the phenotype of HPCs is investigated in the primary HCC model.

[Experimental study on the retentive force of cobalt-chromium alloy, pure titanium and vitallium cast clasps in the simulated 3-year clinical use].

Purpose: To investigate the changes of retentive force of cobalt-chromium alloy, pure titanium and vitallium cast clasps in the simulated 3-year clinical use.

Methods: Fifteen metal abutment crowns made of No.QT800-2 nodular cast iron were used in the test.

[Rehabilitation by hollow obturator prosthesis immediately after total maxillectomy for malignant tumor].

Objective: The feasibility and clinical effects of hollow obturator prosthesis for the repair of maxillofacial defect immediately after maxillectomy for cancer were assessed.

Methods: Thirteen patients with T3-4aN0M0 maxillary neoplasm were treated by the prostheses immediately after maxillectomy. According to the 3D-CT reconstruction of nasal sinus, the 3D stereoscopic prototype was constructed before the surgery.

[The reconstruction of geometric models of dentition defects based on 3-dimensional industrial computed tomography image].

Purpose: A technique on data capture of plaster models for building 3-dimensional geometric models of dentition defects was presented for the purpose of further computer-aided design and manufacture (CAD/CAM)of removable partial denture.

Methods: A plaster model with dentition defects was scanned with low energy X-ray industrial computed tomography (ICT) for ICT image. The data after image processing and vectorization were transferred to a customized reverse engineering software system, and a CAD model of dentition defects was reconstructed.