Fatty acid desaturation is essential for C. elegans longevity at high temperature.

Metabolic reprogramming is crucial for the adaptation to environmental temperature stress. It is generally accepted that fatty acid (FA) desaturation is suppressed at high temperature, which decreases the ratio of unsaturated FAs to saturated FAs (UFAs/SFAs) to maintain the fluidity of cell membranes and favor cellular survival. Here by working in C.