Ailanthone suppresses the activity of human colorectal cancer cells through the STAT3 signaling pathway.

Ailanthone (AIL) is a major quassinoid extracted from the Chinese medicinal herb, , which has been reported to exert anti‑proliferative effects on various cancer cells. The present study aimed to investigate the antitumor effects of AIL on HCT116 and SW620 colon cancer cells, and to analyze the underlying molecular mechanisms. CCK‑8 assay was used to detect cell viability.

The Efficacy and Safety of the mTOR Signaling Pathway Activator, MHY1485, for Activation of Human Ovarian Tissue.

Background: Premature ovarian insufficiency (POI) is characterized by abnormal ovarian function before the age of 40. POI showed that primordial follicles developed in disorder. mTOR signaling plays a vital role in the process of follicle development.

Comparison of the curative effect of modified medial arc incision of achilles tendon and traditional straight incision in the treatment of old achilles tendon rupture.

Modified medial arc incision of Achilles tendon and traditional straight incision were applied to treat 50 cases of old rupture of Achilles tendon. Among them, there were 20 cases involved in the modified medial arc incision of Achilles tendon (group A).Furthermore, 30 cases accepted traditional straight incision treatment (group B).

Downregulated Expression of linc-ROR in Gastric Cancer and Its Potential Diagnostic and Prognosis Value.

Background: Gastric cancer (GC) is one of the global mortality diseases and has a poor prognosis due to the lack of ideal tumor biomarkers. Numerous studies have shown that long noncoding RNAs (lncRNAs) can affect the occurrence and development of cancer through a variety of signaling pathways. The abnormal expression and specificity of lncRNAs in tumors make them potential biomarkers of cancers.

Ailanthone: A novel potential drug for treating human cancer.

Cancer is the second leading cause of death after cardiovascular disease. In 2015, >8.7 million people died worldwide due to cancer, and by 2030 this figure is expected to increase to ~13.

Clinical significance of the molecular heterogeneity of gastrointestinal stromal tumors and related research: A systematic review.

Gastrointestinal stromal tumors (GISTs) are the most commonly observed mesenchymal tumors of the digestive tract, and they originate from the interstitial cells of Cajal. GISTs can be divided into KIT/PDGFRA‑mutant GISTs and wild‑type GISTs based on the presence or absence of KIT/PDGFRA mutations. Wild‑type GISTs can be divided into succinate dehydrogenase complex (SDH)‑deficient GISTs and non‑SDH‑deficient GISTs.

Reduced expression of circRNA hsa_circ_0067582 in human gastric cancer and its potential diagnostic values.

Background: Gastric cancer (GC) is one of the global mortality diseases and has a poor prognosis due to the lack of ideal tumor biomarkers. Circular RNAs (circRNAs) are an abundant kind of endogenous RNAs that recently are found play a crucial role in the cancer occurrence and development. Nevertheless, little is known with regard to the diagnostic values of these circRNAs for GC.