Plasma Adiponectin Concentrations and Adiponectin Gene Polymorphisms Are Associated with Bronchial Asthma in the Chinese Li Population.

The purpose of this study was to determine the clinical significance of changes in the plasma adiponectin concentration in patients with bronchial asthma and to test the association between the single nucleotide polymorphisms (SNPs) rs2241766 and rs1501299 in the ADIPOQ gene and bronchial asthma in the Chinese Li population. We selected 120 cases and 120 controls, and plasma adiponectin, interleukin (IL)-6, and tumor necrosis factor-alpha (TNF-α) levels were measured by enzyme-linked immunosorbent assay (ELISA). In addition, we genotyped two tag single nucleotide polymorphisms (tSNPs) and evaluated their association with bronchial asthma using the χ2 test and genetic model analysis.

[Epidemiological study of malignant tumor among rubber workers in Hainan Province].

Objective: To investigate the prevalence of malignant tumor and its influencing factor among rubber workers in Hainan Province of China, and to study the high incidence of cancer and type of work.

Methods: A retrospective cohort study on registered workers over 1 working age among partial rubber factories in Hainan Province in the period from 2005 to 2010.

Result: There was a remarkable difference in the incidence between nature exposed rubber group and non-exposed group (χ(2) = 52.

An epidemiology study of bronchial asthma in the Li ethnic group in China.

Objective: To investigate the prevalence and risk factors of bronchial asthma in the Li ethnic group in Hainan, China.

Methods: This study employed a stratified random sample design using custom-designed questionnaires. Subjects with asthma-like symptoms were first identified by two rounds of surveys and then confirmed by respiratory physicians using pulmonary function test, bronchial dilation test and challenge test.

[Prevalence and risk factors of bronchial asthma among Li nationality in Hainan province].

Objective: To study the risk factors of bronchial asthma of Li nationality in Hainan.

Methods: A total of 13 050 subjects of Li nationality were selected by random unequal ratio stratified cluster sampling method from southern, central and western part of Hainan and investigated with Hainan Epidemiological Asthma Survey Questionnaire of Li Nationality. There were 441 cases of bronchial asthma, and 1296 cases of control that were sampled by random number table method.

[Effect of TXA2 inhibitor on the proliferation and apoptosis of hypoxic pulmonary artery smooth muscle cells of porcines].

Objective: To study the effect of Thromboxane A2 (TXA2) inhibitor on the proliferation of hypoxic pulmonary artery smooth muscle cells (PASMC) of porcines.

Methods: The methods of 3(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT), immunohistochemistry of Ki67 and TdT-mediated dUTP nick end labeling (TUNEL) were employed to measure the proliferation, inhibition rate and apoptosis of PASMC.

Results: U46619, a thromboxane A2 agonist, could promote the proliferation and expression of Ki67 in PASMC under hypoxic and normal conditions.

[Prevalence survey on bronchial asthma of Li nationality in Hainan from 2003 to 2007].

Objective: To learn the prevalence rate and distribution of bronchial asthma of Li nationality in Hainan by epidemiological survey so as to provide rationales for preventing and treating asthma.

Methods: A total of 13 050 subjects of Li nationality in Hainan were investigated by random sampling of stratified cluster method with an unequal ratio according to the medical records, physical signs and symptoms and pulmonary function tests. Then the prevalence was analyzed according to different population characteristics.

[Serum adiponectin level in patients of chronic pulmonary heart disease with cardiac failure].

Objective: To investigate the changes of the concentration of serum adiponectin in patients of chronic pulmonary heart disease (CPHD) with cardiac failure.

Methods: Thirty-eight CPHD patients with cardiac failure underwent conventional treatment, and were divided into 2 subgroups: remission subgroup (n = 32) and non-remission subgroup (n = 6) according to the therapeutic effects 2 weeks later. Peripheral blood samples were collected from these 38 CPHD patients (CPHD group), including the remission subgroup and non-remission subgroup, and 30 healthy persons (as normal control group).