Publications by authors named "Haiwang Shi"
Article Synopsis
- After a heart attack, the heart experiences negative changes like inflammation and fibrosis, which can lead to worsening heart function.
- The study focuses on a new microneedle patch that can release multiple medications in a timed sequence to target these changes effectively.
- Testing on rats showed that this patch improved heart health by reducing inflammation and enhancing function compared to a control patch, suggesting it's a promising approach for post-heart attack treatment.
Aerobic exercise suppresses CCN2 secretion from senescent muscle stem cells and boosts muscle regeneration in aged mice.
J Cachexia Sarcopenia Muscle
October 2024
Background: Aging negatively impacts tissue repair, particularly in skeletal muscle, where the regenerative capacity of muscle stem cells (MuSCs) diminishes with age. Although aerobic exercise is known to attenuate skeletal muscle atrophy, its specific impact on the regenerative and repair capacity of MuSCs remains unclear.
Methods: Mice underwent moderate-intensity continuous training (MICT) from 9 months (aged + Ex-9M) or 20 months (aged + Ex-20M) to 25 months, with age-matched (aged) and adult controls.
Background: Nanoparticles (NPs) have been extensively utilized as a drug delivery system to control the release of therapeutic agents to treat cardiac injuries. However, despite the advantages of utilizing NP-based drug delivery for treating heart diseases, the current delivery system lacks specificity in targeting the cardiac tissue, thus limiting its application.
Methods: We created three linear peptides, each consisting of 16-24 amino acids.
Article Synopsis
- Scientists studied how muscles can get weaker from things like not moving for a long time (like in space or being bed-ridden).
- They used electrical stimulation (ES) to help prevent muscles from getting weak and tried mixing different stimulation frequencies to see what works best.
- They found that using high-frequency stimulation helped the muscles stay stronger and grow better, even when the rats were not active for a while.