Screening study on significant Chinese herb for anti-idiopathic pulmonary fibrosis by combining clinical experience prescriptions and molecular dynamics simulation technologies.

Various techniques such as data mining, network pharmacology, molecular docking and molecular dynamics simulation were used in this study to screen and validate effective herbal medicines for the treatment of idiopathic pulmonary fibrosis (IPF) and to reveal their mechanisms of action at the molecular level. The use of this approach will provide new tools and ideas for future drug screening, especially for the application of herbal medicines in the treatment of complex diseases. Among them, the five identified core targets, including IL6, TP53, AKT1, VEGFA, and TNF, as well as a series of major active compounds, will be important references for future anti-IPF drug development.

Can Post-Retirement Work Always Prevent Depression?

Given the rising popularity of post-retirement work and its potential benefits for older adults' mental health, this study examined older adults' adaptation ability as a conditional factor for the impact of post-retirement work on depression. Quantitative data from 1433 working older adults and 1433 non-working older adults were analyzed using the PROCESS macro in SPSS to test a moderated regression model with adaptation ability as the moderator. Results showed that older adults with lower adaptation ability demonstrated significantly lower depression if they worked (vs.

Spinach-based RNA mimicking GFP in plant cells.

Spinach RNA-mimicking GFP (S-RMG) has been successfully used to monitor cellular RNAs including microRNAs in bacterium, yeast, and human cells. However, S-RMG has not been established in plants. In this study, we found that like bacterial, yeast, and human cellular tRNAs, plant tRNAs such as tRNA can protect and/or stabilize the Spinach RNA aptamer interaction with the fluorophore DFHBI enabling detectable levels of green fluorescence to be emitted.

Rice Root Hair Phenotypes Imaged by Cryo-SEM.

Cryo-scanning electron microscopy (cryo-SEM) was first introduced for scientific use in the 1980s. Since then, cryo-SEM has become a routine technique for studying the surfaces and internal structures of biological samples with a high water content. In contrast to traditional SEM, cryo-SEM requires no sample pretreatment processes; thus, we can obtain the most authentic images of the sample shape and structure.

Microwave-assisted mass synthesis of MoWS alloy composites with a tunable lithium storage property.

Layered transition metal disulfides (TMDs) possess intriguing properties and hold enormous potential for applications in electronic, optoelectronic, catalytic and energy storage devices. It is an emerging and impactful technology to develop TMD alloys for diverse applications, but mass synthesis of the TMD alloys with tunable compositions and properties remains a major challenge. Herein, we develop a facile but effective microwave-assisted solvothermal method for mass production of Mo1-xWxS2 (0 ≤ x ≤ 1) alloy composites.

Salt and water co-assisted exfoliation of graphite in organic solvent for efficient and large scale production of high-quality graphene.

Graphene has attracted enormous attention due to its unique physical properties and attractive applications in many fields. However, it is an ongoing challenge to develop a facile and low-cost method for the large scale preparation of high-quality graphene (HQGr). In this work, we have developed an improved liquid-phase exfoliation method to mass produce HQGr.

MoWS for Q-switched pulse generation in ytterbium-doped fiber laser.

In this work, we fabricate the MoWS by microwave-assisted solvothermal method, and report the Q-switched Yb-doped fiber lasers (YDFL) using MoWS polymer film and tapered fiber as the saturable absorbers (SAs). The modulation depth and saturable intensity of the film SA are 5.63% and 6.