Publications by authors named "Haitham Ali Kadhim"
Smart Nanoformulation Based on Polymeric Magnetic Nanoparticles and Vincristine Drug: A Novel Therapy for Apoptotic Gene Expression in Tumors.
Sharafaldin Al-Musawi Sumayah Ibraheem Salih Abdul Mahdi Salim Albukhaty Adawiya J Haider Afraa Ali Kadhim Kadhim Ali Kadhim Haitham Ali Kadhim
Life (Basel)
January 2021
Background: Advanced nanobiotechnology provides safe and efficient drug delivery systems to deliver chemotherapy that targets cancer cells efficiently.
Methods: A polymeric-magnetic nanocarrier was composed of a dextran (DEX) shell, a superparamagnetic iron oxide (SPION) core and was conjugated with folate (FA) to carry the anticancer drug vincristine (VNC) in Tera-1 testicular tumor cells. The molecular mechanisms by which apoptosis was induced were analyzed using flow cytometry and qPCR, which exhibited anticancer activity of nanoparticles (NPs).