Clinical effects of laparoscopic versus open radical prostatectomy in the treatment of early prostate cancer.

The objective of this study was to investigate the clinical effects of laparoscopy vs open radical prostatectomy in treating early prostate cancer. Eighty-six early prostate cancer patients accepted therapy in Renmin Hospital of Wuhan University from January 2020 to June 2022 were chosen to be the study participants. They were randomly divided into a control group (CG) and a study group (SG).

MultiObjective optimization of the design of a protective components to chassis protection module for unmanned armored vehicles.

Armored unmanned vehicles are common targets on battlefields and face many complex threats, such as explosions, gunfire, and drones. Additionally, the threat of explosions that originate underneath the vehicles is a major factor in armored vehicle incapacitation. The underbody explosion protection of lightweight, high-mobility armored vehicles has become a key issue in the design of armored vehicles around the world.

Comparison of the Immune Enhancing Activity and Chemical Constituents Between Imitation Wild and Cultivated Astragali Radix.

Astragali Radix (AR), a traditional food and medicinal herb used for thousands of years, is widely recognized for its role in enhancing immunity, particularly when combined with adjuvant chemotherapy. The two primary types of AR available in the market are imitation wild AR (grown for seven years) and cultivated AR (grown for two years). However, whether differences exist in their immune-enhancing effects and chemical constituents remains unclear.

All-Small-Molecule Supramolecular Hydrogel Combining Self-Delivery and ROS-Responsive Release for Inhibiting Tumor Growth and Postoperative Recurrence.

Supramolecular hydrogels show unprecedented advantages and have attracted widespread attention in biomedical sciences. However, it is challenging for bioactive star molecules, such as celastrol, to meet ideal formation conditions. Here, we report a dynamic covalent method to construct a dihydrol-type celastrol-phenylenediboronic acid-guanosine (DHcelPBG) supramolecular hydrogel.

Chloroquine Suppresses Colorectal Cancer Progression via Targeting CHKA and PFKM to inhibit the PI3K/AKT Pathway and the Warburg Effect.

Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide and has become a recognized global health problem. Therefore, the search for new anti-CRC agents or the exploration of new effective drug targets for CRC therapy is urgent. Chloroquine (CQ) is a widely-used antimalarial drug and has shown anti-proliferative effects in CRC.

[Spatial and Temporal Variation Characteristics and Driving Factors of Carbon and Nitrogen Footprint in Wheat and Maize Production Systems in Henan Province].

As the main producing area of wheat and maize in China, Henan Province produces considerable greenhouse gases during the production and planting processes. Determining the characteristics of carbon and nitrogen footprint changes during the growth process and analyzing the key driving factors will provide a basis for the green production of wheat and maize. Based on the life cycle assessment and LMDI model, the spatio-temporal characteristics, composition change trends, and driving factors of the carbon and nitrogen footprint during wheat and maize production in Henan Province from 2011 to 2020 were systematically evaluated.

Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD-Like Pathology in Mice.

The mechanistic target of rapamycin (mTOR) complexes 1 and 2 (mTORC1/2) are crucial for various physiological functions. Although the role of mTORC1 in retinal pigmented epithelium (RPE) homeostasis and age-related macular degeneration (AMD) pathogenesis is established, the function of mTORC2 remains unclear. We investigated both complexes in RPE health and disease.

Scalable Manufacturing of Low-Symmetry Plasmonic Nanospindle Arrays with Tunable Surface Lattice Resonance.

Geometry-dependent plasmonic surface lattice resonances (SLRs) have garnered great interest across a range of applications, including nanolasers, sensors, photocatalysis, and nonlinear optics. However, the rational fabrication of high-quality, low-symmetry, plasmonic nanoparticle arrays over large areas remains challenging. Herein, we report a versatile strategy for the scalable fabrication of centimeter-scale plasmonic nanospindle (NS) arrays with high positional and orientational precision.

Multi-Omics Analysis Reveals That AhNHL Contributes to Melatonin-Mediated Cadmium Tolerance in Peanut Plants.

Cadmium (Cd) pollution significantly hampers cleaner production of peanut (Arachis hypogaea L.). Therefore, exploring of tolerance mechanisms to Cd stress and breeding of low-Cd peanut cultivars are urgently needed and require intense efforts.

Global hotspots and trends of nutritional supplements for sick populations from 2000 to 2024.

Background: Nutritional supplements (NS) can help patients by providing various nutrients such as essential vitamins and minerals, helping to prevent and recover from diseases. This study provides a broad overview of the field of NS for sick people through bibliometrics and visualization analysis, to analyze the status and development dynamics, explore the popular research questions and directions, and reveal the development trends and research frontiers.

Methods: We searched the Web of Science Core Collection databases for literature related to NS for diseased populations from 2000 to 2024.

Extracellular Vesicles From Dental Pulp Cells Promote Osteogenic Differentiation in Periodontal Ligament Cells.

Aim: Periodontal osseous defects are mainly caused by periodontitis, which seriously affects the quality of patient life. Dental pulp cells (DpCs)-derived extracellular vesicles (EVs) can effectively promote tissue regeneration. Homeobox A9 (HOXA9) mRNA is abundant in EVs derived from DSCs, which may be related to promoting alveolar bone regeneration, but the specific mechanism is unclear.

TaERFL1a enhances drought resilience through DHAR-mediated ASA-GSH biosynthesis in wheat.

Wheat is one of the important cereal crops around the world, but it often suffers from abiotic stresses, which threaten food security. Thus, it is critical to identify the genes that determine drought tolerance in wheat. AP2/ERFs are known to regulate drought stress in various crops.

Bilayer or Not: Revisiting the Structural Nature of HBV Subviral Particles.

Hepatitis B virus (HBV) subviral particles (SVPs) are primarily stabilized by protein-protein interactions, with discrete lipid patches playing a supporting role, rather than forming a conventional lipid bilayer, challenging classical assumptions about viral membrane architecture.

Concentration-dependent interactive toxicity of cadmium and mercury: Non-negligible effects on phytoremediation by indigenous Artemisia lavandulaefolia.

The indigenous species Artemisia lavandulaefolia, widespread in areas co-contaminated with Cd and Hg, has the potential for phytoremediation. However, the mechanisms that underlie these plants' resistance to combined Hg and Cd stress are unelucidated. The influence of the dosage of one metal on another has also not been adequately quantified.

Diagnostic value of three urine miRNAs composite score in BK virus nephropathy.

Noninvasive detection of BK virus, for early detection of BK polyomavirus-associated nephropathy post-renal transplantation, is currently an active subject of investigation. In this study, we developed and validated a novel risk score diagnostic assay (PymiR Score) based on measurements of three urine miRNAs, including BKV-related miRNA (bkv-miR-B1-5p), polyomavirus-related miRNA (bkv-miR-B1-3p) and renal tubular injury-related miRNA (miR-21-5p), by quantitative polymerase chain reaction. The limit of detection of the three miRNAs was 2 × 10 copies/mL, while the intra- and inter-assay coefficients of variation were in the ranges of 2.

Decrypting proteomics, transcriptomics, genomics, and integrated omics for augmenting the abiotic, biotic, and climate change stress resilience in plants.

As our planet faces increasing environmental challenges, such as biotic pressures, abiotic stressors, and climate change, it is crucial to understand the complex mechanisms that underlie stress responses in crop plants. Over past few years, the integration of techniques of proteomics, transcriptomics, and genomics like LC-MS, IT-MS, MALDI-MS, DIGE, ESTs, SAGE, WGS, GWAS, GBS, 2D-PAGE, CRISPR-Cas, cDNA-AFLP, HLS, HRPF, MPSS, CAGE, MAS, IEF, MudPIT, SRM/MRM, SWATH-MS, ESI have significantly enhanced our ability to comprehend the molecular pathways and regulatory networks, involved in balancing the ecosystem/ecology stress adaptation. This review offers thorough synopsis of the current research on utilizing these multi-omics methods (including metabolomics, ionomics) for battling abiotic (salinity, temperature (chilling/freezing/cold/heat), flood (hypoxia), drought, heavy metals/loids), biotic (pathogens like fungi, bacteria, virus, pests, and insects (aphids, caterpillars, moths, mites, nematodes) and climate change stress (ozone, ultraviolet radiation, green house gases, carbon dioxide).

The spatiotemporal changes of metabolites in Pinellia ternata at different development stages by MALDI-MSI.

Pinellia ternata is an herb species in the Pinellia genus with significant economic value due to its medicinal properties. Understanding the accumulation and spatial distribution characteristics of metabolites during the development of the medicinal part, the rhizome of P. ternata (PR), provides a basis for targeted metabolic regulation and quality evaluation.

Smooth braking control of excavator hydraulic load based on command reshaping.

Excavators, a type of human-operated construction machinery, suffer from poor hydraulic load braking stability, which seriously affects operator comfort. To address this challenge, this study investigates load braking laws through model analysis and designs an open-loop control algorithm called command reshaping, which can prolong the small-opening time of the main valve by segmentally adjusting the joystick command during load braking and then actively adjusting the key parameters reflecting the system's kinetic-potential energy state, thereby suppressing braking oscillations. The experimental results based on a 1.

Electrochemical Cyclizative Carboxylation of Alkene-Tethered Aryl Isocyanides with Carbon Dioxide.

Herein, we present an unprecedented electrochemical reductive cyclizative carboxylation of -vinylphenyl isocyanides with carbon dioxide achieved without the use of metal catalysts. This protocol demonstrates a broad substrate scope and good functional group tolerance, facilitating the rapid assembly of 2-oxoindolin-3-acetic acids in good to high yields with excellent regioselectivity. Furthermore, these structural motifs may have potential applications in formal synthesis of bioactive natural products.

Interaction of Straw Mulching and Nitrogen Fertilization on Ammonia Volatilization from Oilseed Rape-Maize Rotation System in Sloping Farmland in Southwestern China.

Ammonia (NH) volatilization caused by urea application has negative implications for human health, environmental quality, and the value of nitrogen fertilizers. It remains to be investigated how management strategies should be adopted to not only reduce NH volatilization but also improve nitrogen use efficiency (NUE) in the agriculture industry at present. Hence, a two-year field trial, including subplots, was conducted to simultaneously evaluate the effects of mulching treatments (NM: non-mulching; SM: straw mulching) and different fertilizer treatments (U: urea; U + NBPT: urea plus 1% N-(n-butyl) thiophosphoric triamide; U + CRU: the mixture of urea and controlled-release urea at a 3:7 ratio; U + OF: urea plus commercial organic fertilizer at a 3:7 ratio) on NH volatilization, crop production, and NUE in an oilseed rape-maize rotation system in the sloping farmland of purple soil in southwestern China between 2021 and 2023.

Pathogenesis of fibrosis in patella-patellar tendon junction induced by jumping load in a rabbit model.

The mechanism of fibrosis at the patella-patellar tendon junction (PPTJ) was investigated using a rabbit overuse jumping model. Thirty-two female New Zealand White rabbits were randomly divided into control and jumping groups, and each group was further divided into four groups at 2, 4, 6, and 8 wk. The rabbit in the jumping group jumped 150 times/day, 5 days/wk.

Structural Characteristics of the Fault Zone and Fault-Controlled Hydrocarbon Accumulation in the Chenghai Area of Dagang Offshore.

The Chenghai area is a secondary structural unit within the Qikou sag of the Bohai Bay Basin, located in the southern part of the Dagang offshore area, known for its abundant oil and gas resources. Influenced by multiple episodes of tectonic activity, the Chenghai area exhibits a highly developed fault system, which significantly impacts oil and gas exploration in the region. To investigate the structural characteristics of fault zones in the Chenghai area and their petroleum geological significance, this study builds upon previous research by utilizing oilfield drilling data and relevant seismic information.

Dry Bondable Porous Silk Fibroin Films for Embedding Micropatterned Electronics in Hierarchical Silk Nacre.

Future structural materials is not only be lightweight, strong, and tough, but also capable of integrating functions like sensing, adaptation, self-healing, deformation, and recovery as needed. Although bio-inspired materials are well developed, directly integrating microelectronic patterns into nacre-mimetic structures remains challenging, limiting the widespread application of electronic biomimetic materials. Here, an in situ freeze-drying method is reported for the successful preparation of porous silk fibroin materials that can achieve dry bonding.