Double-layer membrane framework-based gold microelectrode for determination of natural labile copper in complex water environments.

Copper (Cu) is an essential trace element for plankton, but excessive amounts can be toxic and threaten the ecosystems and human health. However, the determination of low concentration labile Cu (Cu) in complex water environments remains a huge challenge. In this work, a gold microelectrode (μ-GE) with high sensitivity and anti-fouling capability was fabricated based on a double-layer membrane framework consisting of ion-exchange polymer (Nafion) and agarose gel (LGL).

Semi-hydrogenation of alkynes to alkenes over Pd nanoparticles embedded in MoC prepared from a high-temperature pulse.

Pd nanoparticles embedded in MoC were successfully prepared from a high-temperature pulse, and are efficient for semi-hydrogenation of alkynes to alkenes, where the embedded Pd sites possessed appropriate alkyne adsorption but suppressed alkene adsorption, thus exhibiting both high activities and good alkene selectivities in the hydrogenation of various alkynes.

In situ measurement of the three-dimensional distribution of labile copper in sediment pore water using a microneedle sensor with nanoporous structure.

Conventional ex situ analytical methods for sediment pore water are susceptible to disruptions in the speciation equilibrium of metals due to changes in external conditions. This study introduced an innovative in situ method for detecting the three-dimensional distribution of labile copper (Cu) in sediment pore water with high spatial resolution using a highly stable microneedle electrochemical sensor. The sensor featured a nanoporous tip structure and embedded gold nanomaterials with excellent electrocatalytic performance.

Field determination and ecological health risk assessment of trace metals in typical mariculture area of China.

Field determination of dissolved trace metals (Cu, Pb and Cd) by using automated electrochemical system had been done in three typical mariculture areas of Yellow Sea (YS), East China Sea (ECS) and South China Sea (SCS) in China. Higher concentrations of Cu and Pb were found in ECS while the Cd concentration showed a decreasing trend from north to south of China. The metal distribution and ecological health risk assessments were also conducted.

Viologen Guest-Mediated Luminescence Emission Tuning and Photochromic Behavior by a Series of Viologen@Zn-MOF Materials.

The encapsulation of various guest molecules into the pores of metal-organic frameworks (MOFs) to form hybrid materials has attracted significant attention due to their unique spatial distribution and certain preferential geometry of the guests inside the MOFs. This arrangement often results in the guests exhibiting unique physical and chemical properties due to their intramolecular interactions with the host. In this article, five viologen derivatives were introduced as guests in a Zn-MOF with different benzene ring lengths, resulting in the formation of host-guest three-dimensional (3D) MOFs.

Deep Vein Thrombosis Is Facilitated by Endothelial-Derived Extracellular Vesicles via the PDI-GRP94-GPIIb/IIIa Pathway in Mice.

Aims: Deep vein thrombosis (DVT) is a prevalent cardiovascular condition. Endothelial-derived extracellular vesicles (EVs) may play a crucial role in platelet-dependent DVT development via platelet activation, but the mechanism is not clear yet. This research aims to understand how platelets and endothelial-derived EVs work in DVT.

A Reliable Low-Latency Multipath Routing Algorithm for Urban Rail Transit Ad Hoc Networks.

With the advancement of urban rail transit towards intelligence, the demand for urban rail transit communication has increased significantly, but the traditional urban rail transit vehicle-ground communication system has been unable to meet the future vehicle-ground communication requirements. To improve the performance of vehicle-ground communication, the paper proposes a reliable low-latency multipath routing (RLLMR) algorithm for urban rail transit ad hoc networks. First, RLLMR combines the characteristics of urban rail transit ad hoc networks and uses node location information to configure a proactive multipath to reduce route discovery delay.

Progression of bilateral morning glory syndrome associated with unilateral persistent fetal vasculture: A case report of long term follow-up in an infant.

Purpose: To describe a case of Bilateral Morning Glory Syndrome (MGS) associated with Unilateral Persistent Fetal Vasculature (PFV) in a 3-day old neonate.

Observations: A 3-day-old neonate was found bilateral retinal abnormalities due to neonatal eye screening. Dilated fundus exam showed bilateral optic disc dysplasia with the persistent hyaloid vessels in right eye at first.

Stimulation of soluble guanylate cyclase by vericiguat reduces skeletal muscle atrophy of mice following chemotherapy.

The chemotherapeutic doxorubicin (DOX) promotes severe skeletal muscle atrophy, which induces skeletal muscle weakness and fatigue. Soluble guanylate cyclase (sGC) contributes to a variety of pathophysiological processes, but whether it is involved in DOX-induced skeletal muscle atrophy is unclear. The present study aimed to stimulate sGC by vericiguat, a new oral sGC stimulator, to test its role in this process.

An antifouling gel-protected iridium needle sensor: Long-term, on-site monitoring of copper in seawater.

Copper (Cu), a natural micronutrient with ecotoxicological significance, is involved in the carbon and nitrogen cycles occurring in marine ecosystems. Here, we developed a novel, antifouling gel-protected iridium (Ir) needle electrode modified with gold nanoparticles (G-IrNS) for long-term continuous and steady Cu monitoring. The gel formed an efficient membrane that effectively prevented the fouling of the sensing surface and displayed anti-convective properties, ensuring that mass transport toward the sensor surface was wholly controlled via diffusion.

Tip-porous microneedle: A highly stable sensing platform for direct determination of labile metals in natural seawater.

Nanomaterial-functionalized voltammetric microsensors are promising tools for detecting trace metals at low concentrations in the complex environment of natural seawater. However, the sensitivity reduction caused by the loss of modified nanomaterials in the detection process has always been a major problem. Herein, to fabricate a highly stable sensing platform, a microneedle electrode with a hierarchical porous tip was prepared through electrochemical etching technology to firmly embed nanoparticles.

Circulating miR-143 and miR-145 as promising biomarkers for evaluating severity of coronary artery stenosis in patients with acute coronary syndrome.

Background: Multiple studies have provided evidence that miR-143 and miR-145 play a crucial role in the pathogenesis and progression of atherosclerosis. In the present study, we aim to investigate the expression of plasma miR-143 and miR-145 in patients with acute coronary syndrome (ACS) and their association with the severity of coronary artery stenosis.

Methods: The study enrolled 279 patients with ACS, including 201 patients with unstable angina (UA) and 78 patients with acute myocardial infarction (AMI), and 65 matched subjects as the control group.

Inequality constraint on the maximum genus for 3D structural compliance topology optimization.

Structural topology constraints in topology optimization are an important research topic. The structural topology is characterized by the topological invariance of the number of holes. The holes of a structure in 3D space can be classified as internally enclosed holes and external through-holes (or tunnels).

Observation and Analysis of Clinical Efficacy of Zhuang Medicine Lotus Acupuncture Cupping Stasis Therapy on Patients with Postherpetic Neuralgia.

Objective: To explore the clinical efficacy of Zhuang Medicine Lotus Acupuncture Cupping Stasis Therapy on patients with postherpetic neuralgia (PHN) and its action mechanism.

Methods: 36 patients are randomly divided into Lotus Acupuncture Cupping Stasis Therapy group, pure cupping group and gabapentin group, with a total of five observation points for the first, fifth, tenth, fifteenth, and twentieth sessions of therapy (one session every three days). At each observation point, the venous blood of the patients is taken, and the contents of and changes in WNT3a, Frizzled8, β-catenin, IL-18, TNF-α, NR2B, NK-1 and SP are tested by ELISA, RT-PCR and WesternBlot, respectively.

Integrated Bioinformatics Analysis Identifies microRNA-200a-5p as a New Plasma Marker in Patients with Venous Thromboembolism.

Background: Venous thromboembolism (VTE) is a major global health problem with high incidence and mortality. Vein endothelial cell (VEC) dysfunction is the primary cause of VTE. MicroRNAs (miRNAs) assist in the regulation of VEC functional pathways.

Design and characteristic analysis of multi-degree-of-freedom ultrasonic motor based on spherical stator.

The multidimensional motion ultrasonic motor with a single spherical stator is studied in this paper. It has the characteristics of miniaturization and can be used in precision motion applications. By bonding six identical pieces of piezoelectric ceramic onto the stator and applying the voltage signal of high frequency, the deformation of the inverse piezoelectric effect is used to excite the stator yaw vibration mode.

Dynamics and temperature field analysis of piezoelectric driven three-stator multi-degree-of-freedom ultrasonic motor.

Since the temperature has a great effect on the service behavior of the ultrasonic motor, high temperature will affect its mechanical characteristics and service life. This article is on a model of a piezoelectric driven three-stator multi-degree-of-freedom ultrasonic motor. Firstly, the motion mechanism is analyzed, and the main causes of temperature rise are determined to be friction heat generation and vibration heat generation.

Nanocomposite based on graphene and intercalated covalent organic frameworks with hydrosulphonyl groups for electrochemical determination of heavy metal ions.

An electrochemical sensor constructed by intercalated composites was developed for determination of heavy metal ions. The intercalated composites were composed of hydrosulphonyl functional covalent organic frameworks (COF-SH) and graphene (G). The presence of numerous adsorption sites, such as 18 sulfur atoms and 30 nitrogen atoms per big circle of COFs on COF-SH, was beneficial for the accumulation of heavy metals, while the graphene enhanced the electrical conductivity.

On-site electrochemical determination of phosphate with high sensitivity and anti-interference ability in turbid coastal waters.

Phosphate is considered to be an important biogenic element and responsible for eutrophication in aquatic ecosystems, existing in both dissolved and absorbed forms. Due to the complex matrix of coastal seawater, a high sensitivity and anti-interference method for phosphate detection is required for environmental protection. In this study, a novel electrochemical method was proposed based on reduced graphene oxide-ordered mesoporous carbon screen-printed electrode (rGO-OMC/SPE) analysis, allowing sensitivity and reliable determination of phosphate in turbid coastal waters.

iT4SE-EP: Accurate Identification of Bacterial Type IV Secreted Effectors by Exploring Evolutionary Features from Two PSI-BLAST Profiles.

Many gram-negative bacteria use type IV secretion systems to deliver effector molecules to a wide range of target cells. These substrate proteins, which are called type IV secreted effectors (T4SE), manipulate host cell processes during infection, often resulting in severe diseases or even death of the host. Therefore, identification of putative T4SEs has become a very active research topic in bioinformatics due to its vital roles in understanding host-pathogen interactions.

Analysis of impedance matching for a spherical multi-degree-of-freedom ultrasonic motor.

A novel spherical multi-degree-of-freedom ultrasonic motor is designed, which can achieve three-degree-of-freedom motion through the cooperative drive of three built-in traveling wave stators. The novel ultrasonic motor has the characteristics of compact structure and high power density. Additionally, in order to solve the problem of impedance mismatch between the ultrasonic motor and the driving power supply, a semi-analytical method of impedance matching based on parallel resonance is proposed according to the impedance characteristics of ultrasonic motor.

Design and Locomotion Study of Stick-Slip Piezoelectric Actuator Using Two-Stage Flexible Hinge Structure.

A novel piezoelectric actuator using a two-stage flexure hinge structure is proposed in this paper, which is used in a compact and high-precision electromechanical field. The two-stage flexure hinge structure is used to provide horizontal thrust and vertical clamping force to the driving feet, which solves the problems of unstable clamping force and insufficient load capacity in traditional stick-slip piezoelectric actuators. Firstly, the main structure of the driver and the working process under the triangular wave excitation voltage are briefly introduced.