Background: Prostate cancer (PCa) is the most common malignant tumor in males with limited therapies. Schizandrin A (SchA) is a biologically active lignan isolated from the fruit of Schisandra chinensis. This research aimed to evaluate the roles and mechanisms of SchA in the progression of PCa.
View Article and Find Full Text PDFWe propose an innovative design for interdigital transducers (IDTs), enabling phase modulation of surface acoustic waves (SAWs) with a dislocated electrode structure. By designing the size and arrangement of these dislocated IDTs, a novel type of Airy SAWs can be generated, exhibiting self-accelerating, self-bending, and self-healing characteristics. The acceleration of the generated Airy SAW is 0.
View Article and Find Full Text PDFA novel seminaphthorhodafluor-based fluorescent probe was designed and prepared. It exhibited an outstanding off-on fluorescence response (about 45-fold enhancement) to Cu because the structure changed from a spirocyclic form to a ring-open state. It showed satisfactory detection performances for Cu with fast response speed, high selectivity and anti-interference, and a low detection limit (22.
View Article and Find Full Text PDFBiochar has been recognised as an efficacious amendment for the remediation of compound heavy metal contamination in soil. However, the molecular mechanism of biochar-mediated tolerance to compound heavy metal toxicity in cotton is unknown. The objective of this research was to investigate the positive impact of biochar (10 g·kg) on reducing damage caused by compound heavy metals (Cd, Pb, and As) in cotton (Gossypium hirsutum L.
View Article and Find Full Text PDFObjective: Although many clinical studies have shown that ROUX-en-Y gastric bypass (RYGB) surgery significantly improves metabolic syndrome-related erectile dysfunction (MED), the role and mechanism are unclear.
Aim: In this study we used a mouse model to explore how RYGB improves MED induced by a high-fat diet (HFD).
Methods: We established a mouse model of metabolic syndrome by feeding an HFD for 16 weeks.
Microwave ablation (MWA) is an effective treatment for liver cancer (LC), but its impact on distant tumors remains to be fully elucidated. This study investigated the abscopal effects triggered by MWA treatment of LC, at different power levels and with or without combined immune checkpoint inhibition (ICI). We established a mouse model with bilateral subcutaneous LC and applied MWA of varied power levels to ablate the right-sided tumor, with or without immunotherapy.
View Article and Find Full Text PDFJ Environ Sci (China)
March 2024
Due to the unique self-acceleration, self-healing, and non-diffraction properties, Airy beams have been explored extensively and found applications in various fields. It has been proven as an essential aspect to tune the trajectory of Airy beams for extensive applications. In this paper, we propose a method based on liquid crystal (LC) alignment with metasurfaces, which enables dynamic tuning of the trajectory of Airy beams.
View Article and Find Full Text PDFThis paper presents a novel tunable narrowband photodetector based on Ag-MgF-Ag (metal-dielectric-metal: MDM) Fabry-Perot (FP) microcavity structure. The tunability is achieved through precise adjustment of the thickness of the metal and intermediate dielectric layers of the FP microcavity, taking into account the response spectral range of planar perovskite. After optimizing the parameters mentioned above, the prototype devices were prepared by combining the perovskite layer and MDM layer.
View Article and Find Full Text PDFStrong fluorescence and high catalytic activities cannot be achieved simultaneously due to conflicts in free electron utilization, resulting in a lack of bioactivity of most near-infrared-II (NIR-II) fluorophores. To circumvent this challenge, we developed atomically precise Au clusters with strong NIR-II fluorescence ranging from 950 to 1300 nm exhibiting potent enzyme-mimetic activities through atomic engineering to create active Cu single-atom sites. The developed AuCu clusters show 18-fold higher antioxidant, 90-fold higher catalase-like, and 3-fold higher superoxide dismutase-like activities than Au clusters, with negligible fluorescence loss.
View Article and Find Full Text PDFX-rays have developed into an essential tool in variety of fields, such as biology, materials, chemistry, and physics etc. Numerous X-ray types, including the orbital angular momentum (OAM), the Laguerre-Gauss, and the Hermite-Gauss states, have been proposed. This greatly enhances the depth of application of X-ray.
View Article and Find Full Text PDFObjectives: The aim of this study was to synthesize and characterize a novel NO donor, PEI-PO-NONOate, using propylene oxide and to investigate its biosafety and therapeutic efficacy via nasal administration in vitro and vivo.
Experimental Procedures: The PEI-PO-NONOate was synthesized based on polyethylenimine (PEI) with different molecular weights and characterized using Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR), and ultraviolet (UV) spectroscopy. Cytotoxicity assays were performed on mouse fibroblast cells L929 and human nasal mucosa epithelial cells (HNEpC), and a rat middle cerebral artery occlusion (MCAO) model was established to evaluate the therapeutic efficacy of PEI-PO-NONOate via nasal administration.
Objective: Evaluate the efficacy and safety of transarterial chemoembolization (TACE) sequential with hepatic arterial infusion chemotherapy (HAIC) and a tyrosine kinase inhibitor (TKI) for unresectable large hepatocellular carcinoma (HCC).
Methods: Patients with HCC size > 70 mm were included. They received 1-3 cycles of TACE and sequential HAIC every 3-6 weeks for 2-6 cycles, with each cycle given over a period of 48 hours (oxaliplatin plus fluorouracil/leucovorin).
Objective: Our objective was to evaluate the feasibility of XperCT combined fluoroscopy to guide sharp recanalization for the treatment of chronic thoracic venous occlusive disease in hemodialysis patients.
Methods: The records of hemodialysis patients with chronic thoracic venous occlusive disease who received endovascular sharp recanalization after conventional techniques failed were retrospectively reviewed. The sharp devices used for recanalization included the stiff end of a guidewire, Chiba biopsy needle, RUPS-100 set, and transseptal needle.
Although immunotherapy of hepatocellular carcinoma using immune checkpoint inhibitors has achieved certain success, only a subset of patients benefits from this therapeutic strategy. The combination of immunostimulatory chemotherapeutics represents a promising strategy to enhance the effectiveness of immunotherapy. However, it is hampered by the poor delivery of conventional chemotherapeutics.
View Article and Find Full Text PDFNatural hyperbolic materials (HMs) in two dimensions (2D) have an extraordinarily high anisotropy and a hyperbolic dispersion relation. Some of them can even sustain hyperbolic polaritons with great directional propagation and light compression to deeply sub-wavelength scales due to their inherent anisotropy. Herein, the anisotropic optical features of 2D natural HMs are reviewed.
View Article and Find Full Text PDFBoth the lighting quality and driving safety inside the tunnel have been quite a concern around the world. In this study, a plate with prism array of total internal reflection (TIR-PA) has been designed to enhance the lighting on the road surface inside the tunnel in adherence to traffic safety as well as energy savings. Such optical elements, above the tunnel sidewall, can redirect the rays emitted from both the headlight and lighting devices to the road surface, which supports higher flux on the road.
View Article and Find Full Text PDFThe surface properties of organic-inorganic hybrid perovskites can strongly affect the efficiency and stability of corresponding devices. Even though different surface passivation methods are developed, the microscopic structures of solution-processed perovskite film surfaces are not systematically studied. This study uses low-temperature scanning tunneling microscopy to study the organic-inorganic hybrid perovskite thin films, MA FA PbI and MAPbI , synthesized by the spin-coating method.
View Article and Find Full Text PDFChiral recognition is an emerging field of modern chemical analysis, and the development of health-related fields depends on the production of enantiomers. Cellulose is a kind of natural polymer material with certain chiral recognition ability. Limited by the chiral recognition ability of natural cellulose itself, more cellulose derivatives have been gradually developed for chiral recognition and separation.
View Article and Find Full Text PDFObjective: This study aims to investigate the association between clinical factors of patients with central (superior vena cava, brachiocephalic, or subclavian) venous occlusion or central venous stenosis (CVO/CVS) and the difficulty of interventional recanalization as well as the duration of postoperative patency.
Methods: A total of 103 hemodialysis patients with CVO/CVS treated with endovascular treatment were enrolled. The two-step cluster analysis was selected to differentiate the cases into distinct phenotypes automatically.
Spin-orbit coupling plays an important role in the spin Hall effect and topological insulators. Bose-Einstein condensates with spin-orbit coupling show remarkable quantum phase transition. In this work we control an exciton polariton condensate - a macroscopically coherent state of hybrid light and matter excitations - by virtue of the Rashba-Dresselhaus (RD) spin-orbit coupling.
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