Publications by authors named "Haisong Lu"
Background: In cardiac surgical procedures, patients carrying high-risk profiles are prone to encompass complicated cardiopulmonary bypass (CPB) separation. Intraoperative transesophageal echocardiography (TEE), a readily available tool, is utilized to detect cardiac structural and functional pathologies as well as to facilitate clinical management of CPB separation, especially in the episodes of hemodynamic compromise. However, the conventional TEE examination, always performed in a liberal fashion without any restriction of view acquisition, is relatively time-consuming; there appear its flaws in the context of critically severe status.
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- - Chinese patients with acute aortic dissection (AD) are generally about 10 years younger and have different clinical characteristics compared to patients from Western countries, such as a higher prevalence of Marfan syndrome and a lower rate of surgical interventions.
- - Younger Chinese patients tend to present with type A AD and familial cases, while older patients are more likely to be female and have type B AD; overall, surgical interventions decrease with increasing age.
- - During a median follow-up of 2.2 years, long-term mortality rates were notably higher in older patients (especially those above 70), and the recurrence of AD was significant across all age groups, highlighting the need for focused care in both young and older patients.
Aims: Increased myofilament contractility is recognized as a crucial factor in the pathogenesis of hypertrophic cardiomyopathy (HCM). Direct myofilament desensitization might be beneficial in preventing HCM disease progression. Here, we tested whether the small molecule fropofol prevents HCM phenotype expression and disease progression by directly depressing myofilament force development.
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- - The study focuses on the role of lncRNA CASC2 in the development of hypoxia-induced pulmonary hypertension (PH) and its effects on vascular remodeling.
- - Researchers used various methods, including qRT-PCR and cell assays, to find that lncRNA CASC2 levels were reduced in the pulmonary tissues of rats with hypoxic PH, and its up-regulation led to decreased cell proliferation and migration.
- - The findings suggest that lncRNA CASC2 can inhibit changes in pulmonary artery smooth muscle cells, preventing abnormal vascular remodeling associated with hypoxia-induced PH.
Supranormal contractile properties are frequently associated with cardiac diseases. Anesthetic agents, including propofol, can depress myocardial contraction. We tested the hypothesis that fropofol, a propofol derivative, reduces force development in cardiac muscles via inhibition of cross-bridge cycling and may therefore have therapeutic potential.
View Article and Find Full Text PDFBackground: Mild fluctuations in serum potassium (K) levels are related to the prognosis of cardiovascular disease. This study aimed to determine the effect of admission serum potassium levels on in-hospital and long-term mortality in patients with Stanford type A acute aortic dissection (AAD).
Materials And Methods: A total of 588 consecutive patients with type A AAD were enrolled, and they were grouped according to admission serum potassium level: <3.
Objectives: Inflammation has been shown to be related with acute aortic dissection (AAD). The present study aimed to evaluate the association of white blood cell counts (WBCc) on admission with both in-hospital and long-term all-cause mortality in patients with uncomplicated Stanford type B AAD.
Methods: From 2008 to 2010, a total of 377 consecutive patients with uncomplicated type B AAD were enrolled and then followed up.
Objectives: To evaluate the association of onset season with clinical outcome in type A acute aortic dissection (AAD).
Design: A single-centre, observational retrospective study.
Setting: The study was conducted in Fuwai Hospital, the National Centre for Cardiovascular Disease, Beijing, China.
Studies have shown inflammation is involved in the development of acute aortic dissection (AAD). The hypothesis that white blood cell count (WBCc) on admission may have an impact on the short- and long-term outcomes of type A AAD was tested in a large-scale, prospective observational cohort study.From 2008 to 2010, a total of 570 consecutive patients with type A AAD in Fuwai hospital were enrolled and were followed up.
View Article and Find Full Text PDFRelapse is the leading cause of mortality in children with acute lymphoblastic leukemia (ALL). Among chemotherapeutics, thiopurines are key drugs in ALL combination therapy. Using whole-exome sequencing, we identified relapse-specific mutations in the phosphoribosyl pyrophosphate synthetase 1 gene (PRPS1), which encodes a rate-limiting purine biosynthesis enzyme, in 24/358 (6.
View Article and Find Full Text PDFLimited studies with relatively small sample sizes have reported that elevated d-dimer levels on admission were associated with increased risk of short-term mortality in patients with type A acute aortic dissection (AAD). However, there were unavailable data regarding the impact of admission d-dimer levels on long-term outcomes. Our present study aimed to evaluate the association of admission d-dimer levels with both inhospital and long-term all-cause mortality in patients with type A AAD.
View Article and Find Full Text PDFComparison of two tranexamic acid dose regimens in patients undergoing cardiac valve surgery.
J Cardiothorac Vasc Anesth
October 2014
Article Synopsis
- Tranexamic acid (TA) is an antifibrinolytic drug that helps reduce postoperative bleeding and the need for blood transfusions in cardiac surgery, but the best dosing method remains unclear.
- A study conducted in China randomly assigned 175 cardiac valve surgery patients to either a lower-dose TA group or a higher-dose TA group to evaluate effectiveness in minimizing bleeding and transfusion requirements.
- Results indicated no significant difference in postoperative bleeding volumes or transfusion needs between the two groups, suggesting that the lower-dose TA regimen is just as effective as the higher-dose regimen.
Article Synopsis
- - The fACE2 gene from domestic cat lungs was isolated using RT-PCR and found to be 2418 base pairs long, closely resembling human ACE2 compared to other non-primate animals.
- - A specific fragment of the gene (19-367 amino acids) was produced in E. coli for further study.
- - Tests showed that fACE2 effectively interacts with the SARS-CoV S1 protein, similar to the way human ACE2 does in Vero E6 cells.
S1 gene fragment containing receptor-binding region was amplified by several sets of primers using Over-Lap PCR. The native S1 gene was modified at A + T abundant regions; n.t.
View Article and Find Full Text PDF[Study on immunogenicity of the N-terminal polypeptide of RTX toxin I of Actinobacillus pleuropneumoniae].
Sheng Wu Gong Cheng Xue Bao
January 2006
Article Synopsis
- * Two forms of the ApxI protein (rApxIA and rApxIAN) were produced in E. coli, both showing similar immune responses to natural ApxI in tests.
- * Immunization studies in mice revealed that while rApxIA and natural ApxI generated higher antibody levels, both rApxIA and rApxIAN provided strong protection rates against different serovars of APP after subsequent boosting.