Publications by authors named "Hairun Yan"
Article Synopsis
- Hospital-acquired infections caused by multidrug-resistant (MDR) bacteria are a global health concern, with combination therapy being a potential treatment option.
- The study assessed the effectiveness of various combinations of meropenem with other antibiotics against MDR clinical strains, utilizing multiple tests to characterize antibiotic resistance.
- Findings indicated that certain combinations, especially involving meropenem, showed synergistic effects, and genetic analysis revealed variability in the NDM-1 gene among strains, which could contribute to its rapid spread.
Previous studies have demonstrated that ephrin (Eph) family receptor tyrosine kinases and ligands promote cancer growth, invasion and metastasis. In addition, it has been reported that Eph receptor A7 (EphA7) is transcriptionally activated in lung cancer; however, the effects of silencing EphA7 expression on the growth of lung cancer cells, and the underlying molecular mechanisms, have yet to be determined. Therefore, the present study aimed to investigate whether silencing EphA7 with small interfering (si)RNA could induce apoptosis in non‑small cell lung cancer (NSCLC) cells.
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