Tumor necrosis factor receptor-associated factor 5 enhances perianal fistulizing Crohn's disease through epithelial-mesenchymal transition.

Objective: Crohn's disease (CD) is a chronic inflammatory condition of the bowel that remarkably impairs a patient's quality of life and often has a poor prognosis. Perianal fistulizing CD (PFCD) is one of the most common parenteral symptoms of CD and a huge challenge for the management of this illness. This study aimed to elucidate the molecular mechanisms underlying PFCD and identify potential biomarkers to advance our understanding and management of this condition.

Fabrication of Zirconia Ceramic Dental Crowns by Digital Light Processing: Effects of the Process on Physical Properties and Microstructure.

Highly dense zirconia ceramic dental crowns were successfully fabricated by a digital light processing (DLP) additive manufacturing technique. The effects of slurry solid content and exposure density on printing accuracy, curing depth, shrinkage rate, and relative density were evaluated. For the slurry with a solid content of 80 wt%, the curing depth achieved 40 μm with minimal overgrowth under an exposure intensity of 16.

A Critical Review of Biodegradable Zinc Alloys toward Clinical Applications.

Biodegradable zinc (Zn) alloys stand out as promising contenders for biomedical applications due to their favorable mechanical properties and appropriate degradation rates, offering the potential to mitigate the risks and expenses associated with secondary surgeries. While current research predominantly centers on the examination of Zn alloys, notable disparities often emerge between and findings. Consequently, conducting investigations on Zn alloys holds paramount significance in advancing their clinical application.

Static Compressive Behavior and Failure Mechanism of Tantalum Scaffolds with Optimized Periodic Lattice Fabricated by Laser-Based Additive Manufacturing.

Porous tantalum (Ta) scaffolds have been extensively used in the clinic for reconstructing bone tissues owing to their outstanding corrosion resistance, biocompatibility, osteointegration, osteoconductivity, and mechanical properties. Additive manufacturing (AM) has an advantage in fabricating patient-specific and anatomical-shape-matching bone implants with controllable and well-designed porous architectures through tissue engineering. The sharp angles of strut joints in porous structures can cause stress concentration, reducing mechanical properties of the structures.

Autologous platelet-rich plasma for the treatment of nonhealing perineal wounds: a report of two cases.

Introduction: Patients with perineal wounds often encounter difficulty in local wound healing after hemorrhoidectomies. PRP contains a high concentration of platelets and has been used to improve wound healing.

Objective: In this case study, PRP was used in the treatment of nonhealing perineal wounds to expedite wound healing.

Static Compressive Behavior and Material Failure Mechanism of Trabecular Tantalum Scaffolds Fabricated by Laser Powder Bed Fusion-based Additive Manufacturing.

Additively manufactured trabecular tantalum (Ta) scaffolds are promising bone repair materials for load-bearing applications due to their good pore interconnectivity. However, a thorough mechanical behavior evaluation is required before conducting animal studies and clinical research using these scaffolds. In this study, we revealed the compressive mechanical behavior and material failure mechanism of trabecular tantalum scaffolds by compression testing, finite element analysis (FEA), and scanning electron microscopy (SEM).

Astragaloside II alleviates the symptoms of experimental ulcerative colitis and .

Background: Ulcerative colitis (UC) is a chronic inflammatory intestinal disease, and its morbidity is rising worldwide. Previous study indicated that astragaloside II (AS II), a monomeric compound, was used to treat bowel disease. However, the effects of AS II on UC remains unclear.