Publications by authors named "Haiqun Shi"
Abstrct: BACKGROUD: Epidemiological data suggest that maternal occupational exposure to mixed phthalates comprising di(2-ethylhexyl) phthalate (DEHP) increases the risk of congenital heart disease (CHD). In this study, we used mice as an animal model to validate impact of first-trimester DEHP exposure on the risk of CHD in offspring, to elucidate the possible mechanisms and to provide a potential feasible intervention.
Methods And Results: Eight-week-old C57BL/6J pregnant mice were randomly divided into standard and DEHP diet groups.
Article Synopsis
- Folic acid (FA) over-supplementation during pregnancy can lead to negative outcomes for the heart health of offspring, including impaired cardiac function and increased levels of reactive oxygen species (ROS).
- In a study with pregnant mice, over-supplementation was linked to decreased left ventricular ejection fraction and other signs of cardiac dysfunction, as well as downregulation of genes vital for heart health.
- Using antioxidants like N-acetylcysteine showed potential in reversing some of the cardiac damage caused by maternal FA over-supplementation, highlighting the balance needed in FA intake during pregnancy.