Ultra-fast [F]florbetapir PET imaging using the uMI Panorama PET/CT system.

Background: There is a need for faster amyloid PET scans to reduce patients' discomfort, minimize movement artifacts, and increase throughput. The recently introduced uMI Panorama PET/CT system featuring enhanced spatial resolution and sub-200ps TOF offers the potential for shorter scan duration without sacrificing image quality or efficacy to detect Aβ deposition. The study aims to establish a faster acquisition protocol for [F]florbetapir PET imaging using digital PET/CT scanner uMI Panorama, while ensuring adequate image quality and amyloid-β (Aβ) detectability comparable to the standard 10-minute scan.

[Widely targeted metabolomics reveals differences of secondary metabolites in rhizomes of different Coptis species].

To deeply understand the chemical components and functional differences of the rhizomes from different Coptis species, this study employed widely targeted metabolomics for the metabolic profiling of C. chinensis, C. deltoidea, and C.

Feasibility of a deep-inspiration breath-hold [F]AlF-NOTA-LM3 PET/CT imaging on upper-abdominal lesions in NET patients: in comparison with respiratory-gated PET/CT.

Purposes: To explore the clinical feasibility and efficacy of a deep inspiration breath-hold (BH) PET/CT using [F]AlF-NOTA-LM3 on upper abdominal lesions in patients with neuroendocrine tumors (NETs).

Methods: Twenty-three patients underwent a free-breath (FB) whole-body PET/CT, including a 10 min/bed scan for the upper abdomen with a vital signal monitoring for respiratory gating (RG) followed by a 20-second BH PET/CT covering the same axial range. For the upper abdomen bed, the following PET series was reconstructed: a 2-min FB PET; RG PET (6 bins); a 20-second and 15-second BH PET (BH_15 and BH_20).

Evaluation of a novel PET tracer [F]-Florbetazine for Alzheimer's disease diagnosis and β-amyloid deposition quantification.

Unlabelled: [F]-Florbetazine ([F]-92) is a selective PET tracer for β-amyloid (Aβ) depositions with a novel diaryl-azine scaffold to reduce lipophilicity and to achieve higher gray-to-white matter contrast. We aimed to assess its diagnostic value in Alzheimer's disease (AD) and pharmacokinetics characteristics in human subjects.

Methods: Six healthy controls (HCs) and nine AD patients underwent dynamic PET examination with [F]-Florbetazine and a structural MRI scan.

Evaluation of the safety, biodistribution, dosimetry of [F]AlF-NOTA-LM3 and head-to-head comparison with [Ga]Ga-DOTATATE in patients with well-differentiated neuroendocrine tumors: an interim analysis of a prospective trial.

Purpose: F-labelled somatostatin receptor (SSTR) analogs offer several advantages over Ga in terms of yield, cost, spatial resolution and detection rate. This study presents an interim analysis of a prospective trial designed to assess the safety, biodistribution and dosimetry of [F]AlF-NOTA-LM3, and compare its diagnostic efficacy and clinical management outcomes with [Ga]Ga-DOTATATE or [Ga]Ga-NODAGA-LM3 in patients with well-differentiated NETs.

Methods: Twenty-one patients with histologically confirmed well-differentiated neuroendocrine tumors (G1 and G2) were prospectively recruited.

The status of nuclear medicine in China: the first official national survey.

Aim/introduction: The National Nuclear Medicine Quality Control Center of China conducted the first official survey to investigate the nationwide situation of nuclear medicine in 2020. The survey aimed to unveil the current nuclear medicine situation and its quality control in China.

Materials And Methods: The web-based survey was conducted and the data was collected via the National Clinical Improvement System (NCIS) of China from 1st April to 31st May 2021.

Deep learning model for automatic image quality assessment in PET.

Background: A variety of external factors might seriously degrade PET image quality and lead to inconsistent results. The aim of this study is to explore a potential PET image quality assessment (QA) method with deep learning (DL).

Methods: A total of 89 PET images were acquired from Peking Union Medical College Hospital (PUMCH) in China in this study.

Preclinical and pilot clinical evaluation of a small-molecule carbonic anhydrase IX targeting PET tracer in clear cell renal cell carcinoma.

Purpose: Clear cell renal cell carcinoma (ccRCC) highly expresses carbonic anhydrase IX (CAIX). The purpose of this study was to evaluate Ga-NY104, a small-molecule CAIX-targeting PET agent, in tumor models of ccRCC and patients diagnosed with confirmed, or suspicious, ccRCC.

Methods: The in vivo and ex vivo biodistribution of Ga-NY104 was investigated in CAIX-positive OS-RC-2 xenograft-bearing models.

A quantitative clinical evaluation of simultaneous reconstruction of attenuation and activity in time-of-flight PET.

Background: The maximum likelihood activity and attenuation (MLAA) reconstruction algorithm has been proposed to jointly estimate tracer activity and attenuation at the same time, and proven to be a promising solution to the CT attenuation correction (CT-AC) artifacts in PET images. This study aimed to perform a quantitative evaluation and clinical validation of the MLAA method.

Methods: A uniform cylinder phantom filled with F-FDG solution was scanned to optimize the reconstruction parameters for the implemented MLAA algorithm.

Clinical effect of mitomycin C combined with operation in the treatment of hyperplastic scar of auricle.

Objectives: To observe the clinical effect and recurrence rate of mitomycin C combined with operation in the treatment of hyperplastic scar of auricle with different diameters.

Methods: A total of 53 patients (67 ears) collected from January 2011 to June 2019 were randomly divided into a combined treatment group (31 ears) and a control group (36 ears). The recurrence rate was observed from one year to three years after operation.