Microcystin-LR induces histopathological injury and cell apoptosis in the hepatopancreas of white shrimp, Litopenaeus vannamei.

Microcystin-LR (MC-LR), a common hepatotoxin produced by bloom-forming cyanobacteria, presents a serious threat to the health of aquatic animals. In this study, we studied the impact of MC-LR on hepatopancreas histopathology, enzyme activity, transcriptome, and apoptosis of Litopenaeus vannamei. Thus, shrimp postlarvae (1.

Nitrogen Removal Performance and Microbial Community Structure of IMTA Ponds (Apostistius japonicus-Penaeus japonicus-Ulva).

Denitrification and anaerobic ammonium oxidation (anammox) are key processes for nitrogen removal in aquaculture, reducing the accumulated nitrogen nutrients to nitrogen gas or nitrous oxide gas. Complete removal of nitrogen from aquaculture systems is an important measure to solve environmental pollution. In order to evaluate the nitrogen removal potential of marine aquaculture ponds, this study investigated the denitrification and anammox rates, the flux of nitrous oxide (NO) at the water-air interface, the sediment microbial community structure, and the gene expression associated with the nitrogen removal process in integrated multi-trophic aquaculture (IMTA) ponds (Apostistius japonicus-Penaeus japonicus-Ulva) with different culture periods.

Liver function indicators and risk of hepatocellular carcinoma: a bidirectional mendelian randomization study.

Observational studies have shown an association between liver dysfunction and hepatocellular carcinoma (HCC), but the causality relationship between them is unclear. We aimed to determine whether there is a bidirectional causal relationship between liver function indicators (alanine aminotransferase, ; aspartate aminotransferase, ; alkaline phosphatase, ; -glutamyltransferase, ) and HCC. Our two-sample Mendelian randomization (MR) study acquired single nucleotide polymorphisms (SNPs) associated with liver function indicators (, = 134,182; , = 134,154; , = 118,309; , = 105,030) and with HCC ( = 197,611) from publicly available genome-wide association studies (GWAS) of East Asian ancestry in Japan (BioBank Japan, BBJ).

Improvement on stability of direct modulation laser with integrated active feedback by partial corrugated gratings.

Researchers have developed a uniform grating DFB with an integrated active optical feedback waveguide (UG-AFDFB) to enhance the modulation speed of direct modulation lasers (DMLs) while reducing costs based on identical active layer designations. However, this design has difficulties in obtaining high single mode yield (SMY) and low relative intensity noise (RIN) as a result of the strong optical feedback caused by the integrated active feedback waveguide (AFW) and the random phase of the facet phase. In this paper, a partial corrugated grating DFB with an integrated active optical feedback waveguide (PG-AFDFB) is proposed to address this issue.

Narrow linewidth semiconductor laser with a multi-period-delayed feedback photonic circuit.

A multi-period-delayed feedback (MPDF) photonic circuit constructed by a Sagnac ring and two coupled rings was designed. By coupling a distributed feedback (DFB) laser diode (LD) with the MPDF, a narrow linewidth semiconductor laser was demonstrated. The linewidth of the DFB-LD with MPDF was narrowed to be around 2 kHz, which is reduced by three orders of magnitude, and the linewidth reduction capability could be maintained when the wavelength of the DFB-LD was tuned in a range wider than 3 nm.

[A Retrospective Analysis of Erlotinib and TP/GP Regimen in the Treatment of Advanced Non-small Cell Lung Cancer.].

Background: About 80% lung cancers belong to non-small cell lung cancer (NSCLC) and more than 70% are in advanced stage. The aim of this study was to evaluate the clinical efficacy and toxicity of erlotinib and GP/TP regimen on advanced non-small cell lung cancer.

Methods: Ninety-one advanced NSCLC patients with different treatments from January 2007 to April 2009 in our hospital were retrospectively analyzed.

[Clinical Observation of Erlotinib in the Treatment of Elderly Patients with Advanced Non-small Cell Lung Cancer.].

Background: About 80% lung cancer is non-small cell lung cancer (NSCLC) and more than 70% are in advanced stage. The aim of this study is to evaluate the clinical efficacy and the side effects of erlotinib in the treatment of elderly patients with advanced non-small cell lung cancer.

Methods: Twenty-nine patients with advanced non-small cell lung cancer were treated with erlotinib 150 mg/d, then the adverse reaction and clinical efficacy were recorded during 3 months.