Precise Design of Atomically Dispersed Fe, Pt Dinuclear Catalysts and Their Synergistic Application for Tumor Catalytic Therapy.

Recently, extending single-atom catalysts from mono- to binary sites has been proved to be a promising way to realize more efficient chemical catalytic processes. In this work, atomically dispersed Fe, Pt dinuclear catalysts ((Fe, Pt)-N-C) with an . 2.

A flowerlike FePt/MnO/GOx-based cascade nanoreactor with sustainable O supply for synergistic starvation-chemodynamic anticancer therapy.

The development of versatile nanotheranostic agents has received increasing interest in cancer treatment. Herein, in this study, we rationally designed and prepared a novel flowerlike multifunctional cascade nanoreactor, BSA-GOx@MnO@FePt (BGMFP), by integrating glucose oxidase (GOx), manganese dioxide (MnO) and FePt for synergetic cancer treatment with satisfying therapeutic efficiency. In an acidic environment, intratumoral HO could be decomposed to O to accelerate the consumption of glucose catalyzed by GOx to induce cancer starvation.