Prediction of STAS in lung adenocarcinoma with nodules ≤ 2 cm using machine learning: a multicenter retrospective study.

Background And Objective: Spread through air spaces (STAS) is an important factor in determining the aggressiveness and recurrence risk of lung cancer, especially in early-stage adenocarcinoma. Preoperative identification of STAS is crucial for optimizing surgical strategies. This study aimed to develop and validate machine learning models to predict the presence of STAS using preoperative clinical, radiological, and pathological data in lung cancer patients.

Variations and Clinical Implications of Serum Gal-3 and IL-6 in Heart Failure Individuals Complicated with Renal Impairment.

Objective: To investigate the variations and clinical implications of serum Gal-3 and IL-6 values in individuals with heart failure (HF) complicated with renal impairment.

Study Design: Analytical study. Place and Duration of the Study: Department of Nephrology, The Affiliated Hospital of Hebei University, Baoding, Hebei, China, from May 2022 to 2023.

Artificial intelligence-based model to predict recurrence after local excision in T1 rectal cancer.

Background: According to current guideline, patients with resected specimens showing high-risk features are recommended additional surgery after local excision (LE) of T1 colorectal cancer, despite the low incidence of recurrence. However, surgical resection in patients with low rectal cancer (RC) is challenging and may compromise anal function, leading to a low quality of life. To reduce unnecessary surgical resection in these patients, we used artificial intelligence (AI) to develop and validate a prediction model for the risk of recurrence after LE.

Calibration and Validation of the CSM-CROPGRO-Peanut Model Under Mulched Drip Irrigation Conditions in Xinjiang.

In order to explore the applicability of the peanut growth simulation model CSM-CROPGRO-Peanut under conditions of mulched drip irrigation in Xinjiang, and to determine the optimal scenario for parameter estimation and model validation, field experiments were conducted in 2022 and 2023 on the water and nitrogen regulation of peanut. Based on the water requirements during the stages of peanut growth, three irrigation levels (low, medium, and high) and two nitrogen application levels (100% N and 50% N) were set, resulting in six treatments. An additional control treatment (CK) with a medium irrigation level and no nitrogen application was also included.

Pyroptosis: candidate key targets for mesenchymal stem cell-derived exosomes for the treatment of bone-related diseases.

Bone-related diseases impact a large portion of the global population and, due to their high disability rates and limited treatment options, pose significant medical and economic challenges. Mesenchymal stem cells (MSCs) can differentiate into multiple cell types and offer strong regenerative potential, making them promising for treating various diseases. However, issues with the immune response and cell survival limit the effectiveness of cell transplantation.

Long-Term Intracranial Progression-Free Survival in Lung Cancer Brain Metastases Extended Beyond 50 Months with Gubenxiaoyi Formula (GBXY): A Groundbreaking Case Study.

Background: The prevalence of brain metastases (BM) in lung cancer patients is notably high and is associated with poor prognoses. The efficacy of standard treatment regimens in improving intracranial progression-free survival (IPFS) for lung cancer BM is markedly limited. While traditional Chinese medicine (TCM) has been effective in enhancing the quality of life and prognosis of lung cancer patients, its efficacy in treating BM remains unreported.

Humic Acid with Vertical Adsorption Conformation Enhanced the Transport of Petroleum Hydrocarbon-Contaminated Colloids.

Humic acid (HA) enhances colloidal transport in porous media, yet the mechanisms by which the HA adsorption conformation affects colloid transport remain unclear. This study investigated the influence of HA on the transport of petroleum-hydrocarbon-contaminated soil colloids (TPHs-SC) in saturated sand columns. The presence of TPHs on the colloidal surface occupied adsorption sites, hindering HA from forming a horizontal adsorption conformation, as observed on uncontaminated soil colloids (SC).

Confinement of carbon dots into carboxymethyl cellulose matrice to prepare solid-state fluorescent films and couple with Eu-MOF toward white light-emitting diodes.

As a novel fluorescent carbon nanomaterial, carbon dots are restricted by their poor fluorescence in the solid state, although they exhibit favorable photoluminescence in solution. N-doped carbon dots (N-CDs) and solid-state fluorescence films were prepared using green and renewable cellulose-derived materials, respectively. The hydrogen bonding network of carboxymethyl cellulose (CMC) inhibits the self-aggregation behavior of N-CDs, which leads to solid-state fluorescence.

Sophisticated perspective-takers are distinctive: Neural idiosyncrasy of functional connectivity in the mentalizing network.

Naive perspective-takers often perceive the social world in a simplistic and uniform way, whereas sophisticated ones recognize the diversity and complexity of others' minds. This commonly accepted distinction points to a possibility of greater inter-individual variability in mentalizing for sophisticated than naive perspective-takers, a difference previously overlooked in research. In the current study, participants were asked to watch a mentalizing-related movie and their neural responses, interpretations of the characters' mental states, and eye-gaze trajectories were recorded.

Overexpression of Growth Differentiation Factor 15 Reduces Neuronal Cell Damage Induced by Oxygen-Glucose Deprivation/Reoxygenation via Inhibiting Endoplasmic Reticulum Stress-Mediated Ferroptosis.

Growth differentiation factor 15 (GDF15) can be induced under various stress conditions. This study aimed to explore the role of GDF15 in oxygen-glucose deprivation/reoxygenation (OGD/R)-induced HT22 cells. OGD/R was employed to induce the HT22 cell model, and GDF15 expression was upregulated via transfection.

Neutrophils promote laser-induced choroidal neovascularization by increasing pro-inflammatory cytokines secretion and cell cycle arrest in retinal pigment epithelium.

Inflammation is hypothesized to have essential functions in the development of wet age-related macular degeneration (AMD). Polymorphonuclear neutrophils (PMNs), recognized as major players in inflammation, are typically the first leukocytes to be recruited to an inflammatory site. Previous studies have identified neutrophil aggregates in the lesion site of the choroidal neovascularization model, and systemic depletion of neutrophils in adult mice is associated with reduced choroidal neovascularization (CNV) area, suggesting a pivotal role of PMNs in CNV pathogenesis.

Light-Triggered Plasmonic DNAzyme Walker Enables Precise Subcellular Molecular Imaging with Reduced Off-Mitochondria Signal Leakage.

The development of highly sensitive and precise imaging techniques capable of visualizing crucial molecules at the subcellular level is essential for elucidating mitochondrial functions and uncovering novel mechanisms in biological processes. However, traditional molecular imaging strategies are still limited by off-mitochondria signal leakage because of the "always-active" sensing mode. To address this limitation, we have developed a light-triggered activation sequence activated plasmonic DNAzyme walker (PDW) for accurate subcellular molecular imaging by the combination of an organelle localized strategy, upconversion nanotechnology, and a plasmon enhanced fluorescence (PEF) technique.

Small molecule SIRT1 activators counteract oxidative stress-induced inflammasome activation and nucleolar stress in retinal degeneration.

Background: The nicotinamide adenosine dinucleotide-dependent deacetylase Sirtuin 1 (SIRT1) has been identified as a protective factor that inhibits the activation of nucleotide-binding and oligomerization domain-, leucine-rich repeat-, and pyrin domain-containing protein 3 (NLRP3) inflammasome. However, whether pharmacological SIRT1 activators can protect retinal pigment epithelial (RPE) cells against oxidative and inflammatory injuries related to age-related macular degeneration remains to be explored.

Methods: Two small molecule specific SIRT1 activators (SRT2104 and CAY10602) were tested, with resveratrol being used as a positive control.

Fit Entropy-Based Dynamic Communication Resource Slicing-Optimization Method in Smart Distribution Grids on the Medium-Low-Voltage Side.

With the rapid development of new energy and smart technology, the demand for inter-device communication in medium-low-voltage smart distribution grids has sharply increased, leading to a surge in the variety and quantity of communication services. To meet the needs of diverse and massive communication services, deploying service function chains to flexibly combine virtual resources has become crucial. This paper proposes an optimization method based on fit entropy and network utility to address the limited communication network resources in medium-low-voltage smart distribution grids.

Sperm-origin paternal effects on root stem cell niche differentiation.

Fertilization introduces parental genetic information into the zygote to guide embryogenesis. Parental contributions to postfertilization development have been discussed for decades, and the data available show that both parents contribute to the zygotic transcriptome, suggesting a paternal role in early embryogenesis. However, because the specific paternal effects on postfertilization development and the molecular pathways underpinning these effects remain poorly understood, paternal contribution to early embryogenesis and plant development has not yet been adequately demonstrated.

Camrelizumab plus apatinib in patients with advanced or recurrent endometrial cancer after failure of at least one prior systemic therapy (CAP 04): a single-arm phase II trial.

Background: The combination of anti-programmed death 1 (PD-1) inhibitors and tyrosine kinase inhibitors is an effective treatment strategy in endometrial cancer. We aimed to explore the efficacy and safety of camrelizumab plus apatinib as an alternative therapeutic option in patients with previously treated endometrial cancer.

Methods: This single-arm Simon's two-stage phase II trial was conducted at the Fudan University Shanghai Cancer Center.

A review of groundwater iodine mobilization, and application of isotopes in high iodine groundwater.

Excessive intake of iodine will do harm to human health. In recent years, high iodine groundwater has become a global concern after high arsenic and high fluorine groundwater. A deep understanding of the environmental factors affecting iodine accumulation in groundwater and the mechanism of migration and transformation is the scientific prerequisite for effective prevention and control of iodine pollution in groundwater.

Scutellaria barbata D.Don and Scleromitrion diffusum (Willd.) R.J.Wang inhibits the progression of triple negative breast cancer though the activation inhibition of NF-κB triggered by CAFs-derived IL6.

Ethnopharmacological Relevance: The treatment options for triple-negative breast cancer (TNBC) are limited. Traditional Chinese Medicine (TCM) plays an important role in the treatment of TNBC. The herb pair Scutellaria barbata D.

Predicting Regional Recurrence and Prognosis in Stereotactic Body Radiation Therapy-Treated Clinical Stage I Non-small Cell Lung Cancer Using a Radiomics Model Constructed With Surgical Data.

Purpose: Risk stratification of regional recurrence (RR) is clinically important in the design of adjuvant treatment and surveillance strategies in patients with clinical stage I non-small cell lung cancer (NSCLC) treated with stereotactic body radiation therapy (SBRT). This study aimed to develop a radiomics model predicting occult lymph node metastasis (OLNM) using surgical data and apply it to the prediction of RR in SBRT-treated early-stage NSCLC patients.

Methods And Materials: Patients with clinical stage I NSCLC who underwent curative surgery with systematic lymph node dissection from January 2013 to December 2018 (the training cohort) and from January 2019 to December 2020 (the validation cohort) were included.

Co-doped NaYF:Yb/Er/Tm upconversion luminescent coating to enhance the efficiency of photovoltaic cells.

The use of upconversion luminescent materials to broaden the utilization range of the solar spectrum to enhance the efficiency of photovoltaic cells offers a promising and sustainable approach. However, the low luminescence intensity and easy quenching of upconversion luminescent materials bring serious challenges to the practical application. Herein, a novel method using Co ion doping to regulate the luminescence properties of NaYF:Yb/Er/Tm is proposed.

Production of vanillin via oxidation depolymerization of lignin over Fe- and Mn-modified TS-1 zeolites.

Converting lignin into specific aromatic chemicals for utilization through depolymerization of lignin is an effective way to achieve high-value applications. There are many depolymerization methods that can do this, but there are problems such as harsh reaction conditions, low depolymerization efficiency and uncontrollable target products that need to be solved. This study reports a novel system for the oxidative depolymerization of alkali lignin using Fe- and Mn- modified TS-1 as a catalyst to assist in the highly selective production of vanillin.