Publications by authors named "Haimin Lei"

: Baroni (HCB) is a traditional herb for the treatment of depression in China. However, the active constituents and the underlying mechanisms of its antidepressant effects remain unclear. The aim of this study was to identify the bioactive constituents of HCB and elucidate its underlying mechanism for the treatment of depression.

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The processing of traditional Chinese medicine(TCM) is a core theory within TCM, embodying deep philosophical, cultural, and natural scientific wisdom. Among the various techniques, the "synergistic processing of medicinal materials and excipients" has garnered significant attention due to its uniqueness. This study explored the impact of the adjuvant Glycyrrhizae Radix et Rhizoma on the dynamic process of component transformation during the processing of Aconiti Lateralis Radix Praeparata using techniques such as acidic dye colorimetry, UPLC-Q-TOF-MS/MS, density functional theory(DFT), and molecular dynamics simulations(MDS).

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  • Qingfei Decoction (QFD) is a traditional Chinese medicine known for treating pulmonary diseases, particularly chronic obstructive pulmonary disease (COPD), and has been analyzed to identify its chemical components and mechanisms.
  • The study found 68 compounds in QFD and predicted 30 gene targets, with several compounds, such as ruscogenin and schisandrin A, potentially contributing to its effects against COPD.
  • Experimental results showed that QFD treatment reduced inflammation in COPD by down-regulating the IL-17 signaling pathway, confirming its effectiveness.
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The [Fe]/HO oxidation system has found wide applications in chemistry and biology. Halogenation with this [Fe]/HO oxidation protocol and halide (X) in the biological system is well established with the identification of heme-iron-dependent haloperoxidases. However, mimicking such halogenation process is rarely explored for practical use in organic synthesis.

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  • * Researchers used network pharmacology and a mouse model of COPD to determine that HPMHD improves symptoms by affecting the IL-17 signaling pathway, thereby reducing inflammation and enhancing lung health.
  • * The study confirmed that HPMHD significantly alleviates COPD-related pathology in mice, highlighting its potential as a therapeutic option through the modulation of specific biological pathways involved in lung inflammation.
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The supramolecular chemistry of small chiral molecules has attracted widespread attention owing to their similarity to natural assembly codes. Two-component low-molecular-weight (LMW) hydrogels are crucial as they form helical structures chirality transfer, enabling diverse functions. Herein, we report a pair of two-component chiral LMW hydrogels based on the small molecular drugs baicalin (BA), scutellarin (SCU) and berberine (BBR).

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Ethnopharmacological Relevance: Accumulation of heat in the lungs and stomach (AHLS) is an important syndrome within the realm of traditional Chinese medicine (TCM). It is the fundamental reason behind numerous illnesses, including mouth ulcers, dermatological conditions, acne, and pharyngitis. Jingzhi Niuhuang Jiedu tablet (JN) serves as the representative prescription for treatment of AHLS clinically.

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Ethnopharmacological Relevance: Hypercholesterolemia (HLC) was a key risk factor for cardiovascular disease (CVD) characterized by elevated cholesterol levels, particularly LDL. While traditional Chinese medicine preparations Compound Danshen Pills(CDP) has been clinically used for hypercholesterolemia and coronary heart disease, its specific therapeutic effect on HLC remains understudied, necessitating further investigation into its mechanisms.

Aim Of The Study: The aim of this study was to explore the potential of CDP in treating HLC and elucidate its underlying mechanisms and active components.

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  • The gut microbiota, which lives in our gastrointestinal tract, plays a big role in how our immune system works and can affect diseases like gastrointestinal cancer.
  • This article reviews how different plant ingredients can help with these cancers by changing gut bacteria and their effects on our immune system.
  • It also mentions that while studying gut bacteria is important, it might be more about understanding gut health rather than being the main way to prevent gastrointestinal diseases.
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  • Studies show that the arrangement of chiral molecules greatly impacts how they self-assemble, but the effects of epimerization (changes in a single chiral center) had not been previously examined.
  • This research focused on two epimers of glycyrrhetinic acid—18 α and 18 β—derived from Glycyrrhiza uralensis, which exhibit different medicinal properties.
  • The findings revealed that 18 β-GA can create a nanoparticle structure through a 'head-to-tail' arrangement, while 18 α-GA struggles to assemble due to steric hindrance caused by a 'head-to-head' connection, highlighting how small structural changes can affect molecular behavior and potential applications in medicine.
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Free radical damage and oxidative stress are thought to play a crucial role in the development of neurodegenerative diseases. Walnut peptides, especially walnut oligopeptides, have been shown to protect nerve cells from oxidative stress and inflammatory damage, as well as improve memory function. In this study, walnut peptides were obtained from walnut meal through enzymatic hydrolysis, ultrafiltration, and gel filtration chromatography.

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Direct analysis in real time (DART) enables direct desorption and ionization of analytes, bypassing the time-consuming chromatographic separation traditionally required for mass spectrometry (MS) analysis. However, DART-MS suffers from matrix interference of complex samples, resulting in compromised detection sensitivity and quantitation accuracy. In this study, DART-MS was combined with differential mobility spectrometry (DMS) to provide an additional dimension of post-ionization ion mobility separation within a millisecond time scale, compensating for the lack of separation in DART-MS analysis.

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Ethnopharmacological Relevance: Vascular disease (VD) is a kind of common disease harmful to the health of the middle-aged and elderly, which has the characteristics of long treatment cycle and high recurrence rate, and without effective method to treat so far. Traditional Chinese medicine (TCM) has the characteristics of multi-components and multi-targets to treat diseases. Kai-Xin-San is a TCM formula applied for treating psychiatric diseases such as depression in China for thousands of years, and it has been used in clinical treatment of VD.

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  • Ulcerative colitis (UC) is a chronic inflammatory disease of the colon and rectum, and current treatments are inadequate for patient needs.
  • This study highlights the creation of berberine-hesperetin nanoparticles (BBR-HST NPs) that self-assemble from two natural phytochemicals, demonstrating enhanced anti-inflammatory effects for treating UC.
  • BBR-HST NPs show promising therapeutic potential due to their ability to improve the immune response and intestinal barrier repair, while also being biocompatible and safe for use.
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  • Deaths from bacterial infections are increasing due to antibiotic overuse and bacterial resistance, highlighting the urgent need for new treatment options.
  • Researchers developed a new type of carrier-free binary nanoparticle (GA-BBR NPs) made from traditional herbal ingredients, which showed strong antibacterial properties and was created using an eco-friendly, cost-effective method.
  • The nanoparticles not only effectively kill multidrug-resistant bacteria and help remove biofilms but also promote wound healing without causing significant toxicity, indicating their potential for clinical use in treating infections.
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We investigated the mechanisms underlying the effects of Ziziphora clinopodioides Lam. (ZCL) on atherosclerosis (AS) using network pharmacology and in vitro validation.We collected the active components of ZCL and predicted their targets in AS.

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  • The tumor microenvironment (TME) significantly influences tumor growth and spread, highlighting the need for effective combined cancer therapies.
  • Copper is utilized for chemodynamic therapy due to its unique ability to generate reactive oxygen species when exposed to laser light, offering a new approach to induce tumor cell death through a process called cuproptosis.
  • The reported NCTD Gel is a natural, injectable hydrogel made from glycyrrhizic acid and norcantharidin, which efficiently targets TME and induces cancer cell death while being biocompatible, eco-friendly, and potentially useful in clinical settings.
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Background: Therapeutic approaches based on glycolysis and energy metabolism of tumor cells are new promising strategies for the treatment of cancer. Currently, researches on the inhibition of pyruvate kinase M2, a key rate limiting enzyme in glycolysis, have been corroborated as an effective cancer therapy. Alkannin is a potent pyruvate kinase M2 inhibitor.

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  • Ulcerative colitis (UC) is a chronic inflammatory condition treated using heat-clearing and toxin-removing substances like Coptidis Rhizoma and Bovis Calculus, which contain active compounds berberine (BBR) and ursodeoxycholic acid (UDCA).
  • Researchers developed a new treatment method using UDCA-BBR supramolecular nanoparticles, which were created through a co-decocting process and characterized as tetrahedral nanoparticles with an average size of 180 nm.
  • In experimental studies on mice with UC, these nanoparticles significantly improved various health metrics, including body weight and inflammation markers, while outperforming a standard mechanical mixture of the components.
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Chuanxiong, a traditional Chinese medicine, has been proved to treat a variety of cardiovascular and cerebrovascular diseases by promoting angiogenesis. However, the mechanisms of Chuanxiong's pro-angiogenesis is currently unknown. This study aimed to uncover the effect and mechanisms of Chuanxiong promoting angiogenesis and .

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Multidrug-resistance (MDR) Pseudomonas aeruginosa (P. aeruginosa) is a lethal gram-negative pathogen causing hospital-acquired and ventilator-associated pneumonia, which is difficult to treat. Our previous studies confirmed that baicalin, an essential bioactive component in Scutellaria baicalensis Georgi, exhibited anti-inflammatory effects in an acute pneumonia rat model induced by MDR P.

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We prepared 15 batches of Kaixin Powder benchmark samples with the decoction pieces of different batches. Further, we established the specific chromatograms and index component content determination method of Kaixin Powder benchmark samples and analyzed the peaks and similarity of the chromatograms. With sibiricose A5, sibiricose A6, polygalaxanthone Ⅲ, 3,6'-disinapoyl sucrose, ginsenoside Rb_1, β-asarone, α-asarone, and dehydropachymic acid as index components, the index component content determination method was established and 70%-130% of the mean content of each component was set as the range.

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Unlabelled: Pomegranate seeds are a potential source of bioactive compounds. Nonetheless, most pomegranate seeds are discarded in the food processing industry, likely due to the lack of convincing data on their component analysis.

Methods: To reveal the main chemical constituents of pomegranate seeds, a reliable and sensitive method based on ultra-high-performance supercritical fluid chromatography coupled with electrospray ionization and quadrupole time-of-flight mass spectrometry (MS) was developed.

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Background: The effect of Zanthoxylum bungeanum Maxim. (ZBM) on anti-obesity, lipid-lowering and liver protection has been identified, but the effect on the development of NAFLD induced by high-fat diet remains unclear.

Purpose: To evaluate the alleviation effect of ZBM on NAFLD in vivo and explore the mechanisms by analyzing the liver transcriptome, microbiota and fecal metabolites.

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  • The study focuses on developing new antibacterial agents to combat multidrug-resistant bacteria, particularly Staphylococcus aureus (MRSA).
  • A series of glycyrrhetinic acid (GA) derivatives were synthesized, with compound 11 demonstrating the strongest antibacterial activity against MRSA at an MIC of 3.125 μM, much more effective than traditional antibiotics like penicillin and norfloxacin.
  • The mechanism of compound 11 was found to obstruct arginine biosynthesis and metabolites, and it also showed good biocompatibility in various tests, highlighting its potential as a candidate for treating MRSA infections.
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