Heteroleptic mononuclear Cu(I) halide complexes containing carbazolyl substituted phenyl diphosphine and monophosphine: structures and photophysical and electroluminescent properties.

How to obtain heteroleptic mononuclear Cu(I) halide complexes with high quantum efficiency and short decay lifetime remains a challenge. Here, seven mononuclear four-coordinate Cu(I) halide complexes [CuX(DCzDP)(PPh)] (DCzDP = 1,2-bis(9-carbazolyl)-4,5-bis(diphenylphosphino)benzene, X = Br (1), Cl (2)), [CuX(DCzDP)(CzP)] (CzP = 9-methyl-3-(diphenylphosphino)carbazole, X = I (3), Br (4), Cl (5)) and [CuX(DCzDP)(DCzP)] (DCzP = bis(9-methyl-3-carbazolyl)phenylphosphine, X = I (6), Br (7)), were synthesized and their structures and photophysical properties were characterized. At room temperature, complexes 1-7 in the powder state emit a yellowish green to yellow green delayed fluorescence ( = 531-560 nm, = 0.

Broad-Specificity Screening of Pyrethroids Enabled by the Catalytic Function of Human Serum Albumin on Coumarin Hydrolysis.

Sensing systems based on cholinesterase and carboxylesterase coupled with different transduction technologies have emerged for pesticide screening owing to their simple operation, fast response, and suitability for on-site analysis. However, the broad spectrum and specificity screening of pyrethroids over organophosphates and carbamates remains an unmet challenge for current enzymatic sensors. Human serum albumin (HSA), a multifunctional protein, can promote various chemical transformations and show a high affinity for pyrethroids, which offer a route for specific and broad-spectrum pyrethroid screening.

Quantitative proteomics analysis of chicken embryos reveals key proteins that affect right gonadal degeneration in females.

In birds, embryonic gonads of females develop in a way different from mammals, with the left one develops into a functional ovary, while the right one degenerates during embryogenesis. Here, we examined the proteomics profiles of the female and male left and right gonads at embryonic day 6.5 (E6.

Ultrathin Niobate Nanosheet Assembly with Au NPs and CdS QDs as a Highly Efficient Photocatalyst.

Niobate nanosheets have aroused widespread interest in recent years for their prospects in catalysis. The exploration of 2D niobate catalysis with stable and efficient properties is still the focus in chemistry and materials science. Herein, the successful fabrication of 2D CdS/Au/HNb O catalyst is demonstrated which revealed efficient photocatalytic properties in H evolution, oxidative self-coupling of amines to imines, and degradation of dyes.

LncRNA HOTAIR regulates the expression of E-cadherin to affect nasopharyngeal carcinoma progression by recruiting histone methylase EZH2 to mediate H3K27 trimethylation.

Background/aim: There has been increasing evidence for the function of long non-coding RNA (lncRNA) in nasopharyngeal carcinoma (NPC). We aim to delve into the position of lncRNA HOX antisense intergenic RNA (HOTAIR), together with enhancer of zeste homolog 2 (EZH2), E-cadherin and trimethylation of lysine 27 on histone H3 (H3K27me3) in NPC.

Methods: HOTAIR, EZH2, and E-cadherin expression in NPC tissues and cells were tested.

Unraveling the Mechanism of Near-Infrared Thermally Activated Delayed Fluorescence of TPA-Based Molecules: Effect of Hydrogen Bond Steric Hindrance.

A recently synthesized novel molecule (named CAT-1) exhibits intriguing near-infrared (NIR) thermally activated delayed fluorescence (TADF) close to 1000 nm wavelength; however, the mechanism behind these intrinsic properties is not fully understood. Herein, we unravel that the fluorescence emission spectrum with a broad wavelength range (770-950 nm) of CAT-1 is primarily induced by hydrogen bond steric hindrance based on density functional theory and Marcus theory. It is found that the hydrogen bond steric hindrance plays a critical role in inhibiting the twist of the configuration of different excited states, which leads to the minor driving force for fast electron trapping between the excited states, as well as small internal reorganization energy caused by less changed geometric configuration.

Largely Color-Tuning Prompt and Delayed Fluorescence: Dinuclear Cu(I) Halide Complexes with -Amines and Phosphines.

Luminescent copper(I) halide complexes with bi- and tridentate rigid ligands have gained wide research interests. In this paper, six tetracoordinate dinuclear copper(I) halide complexes, CuX(ppda) [ppda = 2-[2-(dimethylamino)phenyl(phenyl)phosphino]-,-dimethylaniline, X = I (), Br (), Cl ()] and CuX(pfda) [pfda = 2-[2-(dimethylamino)-4-(trifluoromethyl)phenyl(phenyl)phosphino]-,-dimethyl-5-trifluoromethylaniline, X = I (), Br (), Cl ()], were successfully prepared and systematically characterized on their structures and photophysical properties. Complexes - have a centrosymmetric form with a planar CuX unit, and complex has a mirror symmetry form with a butterfly-shaped CuX.

Light Driven Mechanism of Carbon Dioxide Reduction Reaction to Carbon Monoxide on Gold Nanoparticles: A Theoretical Prediction.

Insightful understanding of the light driven CO reduction reaction (CORR) mechanism on gold nanoparticles is one of the important issues in the plasmon mediated photocatalytic study. Herein, time-dependent density functional theory and reduced two-state model are adopted to investigate the photoinduced charge transfer in interfaces. According to the excitation energy and orbital coupling, the light driven mechanism of CORR on gold nanoparticles can be described as follows: the light induces electron excitation and then transfers to the physisorbed CO, and CO can relax to a bent structure adsorbed on gold nanoparticles, and the adsorbed C-O bonds are dissociated finally.

Effects of Polysaccharide on Endoplasmic Reticulum Stress and Oxidative Stress in Obese Mice.

Background: The incidence of obesity-associated decline in male fertility has increased over the years. polysaccharide (LBP), a natural plant polysaccharide extracted from the Chinese herb has shown promising therapeutic effects in overcoming the same.

Aim: This study aimed to investigate the protective effect of LBP on the testes of obese mice.

From a blue to white to yellow emitter: a hexanuclear copper iodide nanocluster.

Highly emissive copper(i) halide nanoclusters showing thermally activated delayed fluorescence (TADF) have been paid much attention, but rarely reported so far. Herein, a hexanuclear copper(i) iodide cluster containing a tridentate N∧P∧N ligand, [CuI(ppda)] {ppda = 2-[2-(dimethylamino)phenyl(phenyl)phosphino]-N,N-dimethylaniline}, was synthesized. All six copper atoms are four-coordinate, including four CuPNI and two CuI units.

Recognition of PDL1/L2 by different induced-fit mechanisms of PD1: a comparative study of molecular dynamics simulations.

Recent clinical data has shown that some cancers choose to express PDL2 compared to PDL1. Therefore, a detailed and comparative study of the dynamic binding mechanism between PD1/PDL1 and PD1/PDL2 can guide drug design towards PD1. Herein, long time-scale classical molecular dynamics simulation, binding free energy calculation, energy decomposition and homology modeling for PD1/PDL2 were used to shed light on the differences in the binding mechanisms of the PD1/PDL1 and PD1/PDL2 complexes.

Impact of RTN4 gene polymorphism and its plasma level on susceptibility to nasopharyngeal carcinoma: A case-control study.

The RTN4 gene plays a role in the development and progression of cancer. This case-control study aimed to investigate the association between the RTN4 gene polymorphism and its plasma level with the risk of nasopharyngeal carcinoma (NPC) in a Chinese population.RTN4 gene polymorphisms (rs2920891, rs17046583, rs117465650, rs10496040, and rs2588519) in 220 patients with NPC and 300 healthy controls were analyzed using Snapshot single-nucleotide polymorphism genotyping assays.

[Association of single nucleotide polymorphisms of rs3819024 and rs8193037 loci of IL-17A gene with the risk of ischemic stroke].

Objective: To assess the association of polymorphisms of rs3819024 and rs8193037 loci in the promoter region of IL-17A gene with the risk of ischemic stroke (IS) among ethnic Han Chinese from Guangxi.

Methods: The polymorphisms of rs3819024 and rs8193037 loci were detected by a SNaPshot assay and DNA sequencing among 392 IS patients and 443 healthy controls with matched age and gender.

Results: The genotypes, dominant model, recessive model, and alleles of rs3819024 polymorphisms showed no significant difference between the two groups, with the P values calculated as 0.

Genetic polymorphisms in interleukin 13 gene with the susceptibility to nasopharyngeal carcinoma in a Chinese population.

Although inflammation is emerging as a candidate risk factor in tumorigenesis of nasopharyngeal carcinoma (NPC). In particular, Interleukin (IL) 13 involved inflammatory diseases and cancers. Single nucleotide polymorphisms in IL-13 have been associated with multiple cancers.

Genetic association of promoter in GRP78 gene with nasopharyngeal carcinoma in a Chinese population.

Background: Emerging evidences were accumulated to support the view that GRP78 might be associated with multiple types of cancer. Given these, the aim of this study is to investigate the relationship between single nucleotide polymorphisms (SNPs) of GRP78 gene promoter and nasopharyngeal carcinoma (NPC).

Methods: Three SNPs (rs3216733, rs17840761 and rs17840762) in GRR78 promoter were estimated in 422 NPC patients and 452 controls.

polysaccharide prevents cisplatin-induced MLTC-1 cell apoptosis and autophagy via regulating endoplasmic reticulum stress pathway.

Background: polysaccharide (LBP) has been reported to contribute to the recovery of male hypogonadism and infertility.

Aim: The aim of current study was to investigate the underlying mechanisms of LBP on male infertility recovery.

Methods: Recently, it is reported that cell apoptosis mediated by endoplasmic reticulum stress (ERS) was distinguished from that mediated by death reporters and mitochondria pathway, which could induce cell apoptosis independently.

Association of GRP78 promoter polymorphisms and serum GRP78 level with risk of asthenozoospermia.

Purpose: The aim of this study was undertaken to investigate the association of 78-kDa glucose-regulated protein (GRP78) gene promoter polymorphisms with risk of asthenozoospermia (AZS) men. In addition, we performed association analysis between GRP78 promoter mutations and serum GRP78 level in asthenozoospermia.

Methods: The study population comprised 400 subjects with AZS patients and 400 healthy controls.

[Asthenozoospermia is not correlated with 3' UTR polymorphisms of the GRP78 gene].

Objective: To investigate the correlation of the single nucleotide polymorphisms (SNPs) rs12009, rs1140763 and rs16927997 in the 3'-untranslated region (3'UTR) of the glucose-regulated protein 78 (GRP78) gene with the risk of male asthenozoospermia (AZS).

Methods: We included 400 AZS patients in the AZS group and another 400 fertile men as normal controls. Using the SNaPshot technique, we genotyped the rs12009, rs1140763 and rs16927997 polymorphisms in the 3'UTR of the GRP78 gene in all the male subjects and analyzed the association of the three SNPs with AZS.

Near-saturated red emitters: four-coordinate copper(i) halide complexes containing 8-(diphenylphosphino)quinoline and 1-(diphenylphosphino)naphthalene ligands.

Recently, highly emissive neutral copper halide complexes have received much attention. Here, a series of four-coordinate mononuclear Cu(i) halide complexes, [CuX(dpqu)(dpna)] (dpqu = 8-(diphenylphosphino)quinoline, dpna = 1-(diphenylphosphino)naphthalene, X = I (1), Br (2) and Cl (3)), were synthesized, and their molecular structures and photophysical properties were investigated. These complexes exhibit near-saturated red emission in the solid state at room temperature and have peak emission wavelengths at 669-691 nm with microsecond lifetimes (τ = 0.

Association between polymorphisms in the promoter region of miR-17-92 cluster and systemic lupus erythematosus in a Chinese population.

The aim of this study was to investigate the association of genetic polymorphisms in the promoter region of miR-17-92 with systemic lupus erythematosus (SLE). The gene polymorphism was analysed using SNaPshot in 312 SLE patients and 396 controls. Relative expression of miR-17-92 was measured by quantitative real-time PCR.

Association of S100B polymorphisms and serum S100B with risk of ischemic stroke in a Chinese population.

The levels of serum S100B were elevated in patients with ischemic stroke (IS), which may be a novel biomarker for diagnosing IS. The aim of this study was to investigate the association of S100B polymorphisms and serum S100B with IS risk. We genotyped the S100B polymorphisms rs9722, rs9984765, rs2839356, rs1051169 and rs2186358 in 396 IS patients and 398 controls using polymerase chain reaction-single base extension (SBE-PCR).

The association of IL-17A polymorphisms with IL-17A serum levels and risk of ischemic stroke.

The aim of our study was to investigate the association of interleukin-17A (IL-17A) polymorphisms with IL-17A serum levels and risk of ischemic stroke (IS) in a Chinese population. 392 IS patients and 443 controls were included in this study. The polymorphisms of IL-17A gene were determined by Snapshot SNP genotyping assay and DNA sequencing.

Overexpression of osteopontin promotes cell proliferation and migration in human nasopharyngeal carcinoma and is associated with poor prognosis.

Nasopharyngeal carcinoma (NPC), a malignant tumor at the top and side of the nasopharyngeal cavity, highly occurs in the southern region of China. Cancer cell metastasis is one of the leading causes of death in NPC patients. Osteopontin (OPN), is a phosphorylated extracellular matrix protein with a variety of functions, was found to be overexpressed in many cancers.