Co-occurrence of organophosphate esters and phosphorus fractions in river sediments: Implications for pollution prediction and environment risk assessment.

Organophosphate esters (OPEs) and phosphorus (P) are widespread pollutants in aquatic ecosystems, presenting potential ecological risks. However, there is still a lack of comprehensive understanding of their relationships in sediments. In this study, we investigated the co-occurrence and behaviors of the OPEs and P in urban river sediments.

The Value of Epicardial Adipose Tissue for Patients Treated with Percutaneous Coronary Intervention: A Systemic Review and Meta-analysis.

Background: Recently, some clinical researches have shown epicardial adipose tissue to play a pivotal role in prognosis for patients treated with percutaneous coronary intervention (PCI), but the results are still controversial. A systematic review and meta-analysis was conducted to investigate the value of epicardial adipose tissue for the prognosis of patients treated with PCI.

Method: A systematic search was performed using PubMed, Web of Science, and the Cochrane Library for studies evaluating the association of EAT and patients treated with PCI published up to January 2023.

A multimodal domain adaptive segmentation framework for IDH genotype prediction.

Purpose: The gene mutation status of isocitrate dehydrogenase (IDH) in gliomas leads to a different prognosis. It is challenging to perform automated tumor segmentation and genotype prediction directly using label-deprived multimodal magnetic resonance (MR) images. We propose a novel framework that employs a domain adaptive mechanism to address this issue.

Weakly Supervised Deep Nuclei Segmentation With Sparsely Annotated Bounding Boxes for DNA Image Cytometry.

Nuclei segmentation is an essential step in DNA ploidy analysis by image-based cytometry (DNA-ICM) which is widely used in cytopathology and allows an objective measurement of DNA content (ploidy). The routine fully supervised learning-based method requires often tedious and expensive pixel-wise labels. In this paper, we propose a novel weakly supervised nuclei segmentation framework which exploits only sparsely annotated bounding boxes, without any segmentation labels.

Assessment of nutrient and heavy metal contamination in surface sediments of the Xiashan stream, eastern Guangdong Province, China.

In this study, nutrient and heavy metal contamination in surface sediments of the Xiashan stream were investigated. Determining pollution degree of nutrient and heavy metal were the main objectives of this investigation. For this reason, the concentrations of total nitrogen (TN), total phosphorus (TP), seven heavy metals (Cu, Zn, Pb, Cd, Cr, Ni, Hg), and metalloid (As) were analyzed at 55 sampling sites.

Antioxidant and xanthine oxidase inhibitory activity of Eucommia ulmoides Oliver leaf extracts.

The total phenolic content, flavonoid content, in vitro xanthine oxidase (XOD) inhibitory activity and antioxidant activity (AA) of Eucommia ulmoides Oliver leaf extracts were investigated. The AA investigations included 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, β-carotene/linoleic acid bleaching assay and oxygen radical absorbance capacity (ORAC) test. The ethyl acetate fraction (EE) showed the highest AA and xanthine oxidase inhibitory activity.

Inhibitory effect of verbascoside on xanthine oxidase activity.

In this study, we analyzed the inhibitory effect of verbascoside against xanthine oxidase (XOD) in vitro by using animal model and in vivo by direct inhibition assay. Results showed that verbascoside could reduce uric acid in rat serum and inhibit XOD activity in rat liver. The IC value of restraining XOD activity was 81.

[Role of p38MAPK/eNOS signaling pathway in the inhibition of AGEs-induced apoptosis of human umbilical vein endothelial cells by glucagon-like peptide-1].

Objective: To investigate the role of p38MAPK signaling pathway in the mechanism by which glucagon-like peptide-1 (GLP-1) inhibits endothelial cell damage induced by AGEs.

Methods: Human umbilical vein endothelial cells were divided into control group, AGEs group, GLP-1 group, AGEs+GLP-1 group, AGEs+inhibitor group, and AGEs+GLP-1+inhibitor group. The expressions of p-p38MAPK/p38MAPK and p-eNOS/eNOS protein were examined by Western blotting, and the cell apoptosis rates were tested by flow cytometry.