Social-economic inequalities and early-life exposure to famine contribute to low grip strength: The China National Health Survey.

Background And Aim: The relationship between socio-economic inequalities (SEIs) and early life malnutrition with muscle health remains unclear. This study aims to examine the effects of SEIs and early life exposure to famine on relative hand grip strength (rHGS).

Methods And Results: We analyzed data of 37,008 individuals from the China National Health Survey.

Linear and non-linear relationships between red blood cell indices and cardiovascular risk factors: findings from the China National Health Survey.

Introduction: Cardiovascular diseases (CVDs) are a leading cause of mortality worldwide. Red blood cell indices (RBIs) are associated with CVD risk factors (CRFs) and easy to test, making them useful as a screening tool for early identification of individuals at high risk for CVDs.

Methods: Data from 31,781 participants in the China National Health Survey conducted from 2012 to 2017 were analyzed.

Design, synthesis and biological evaluation of new SIRT3 activators for the treatment of triple-negative breast cancer.

Triple-negative breast cancer (TNBC) represents a highly malignant subtype of breast cancer with limited therapeutic options. In this study, we designed and synthesized a series of 1,4-DHP derivatives by structure-based strategy, 43 was documented to be a potent SIRT3 activator and exhibited profound anti-proliferative activity in BT-549 and MDA-MB-231 cells with low toxicity over normal cells. Additionally, 43 displayed the ability of direct binding to SIRT3 with a K value of 51.

Spectroscopic characterization of buffer-gas-cooled lead monofluoride molecules in the BΣ(υ' = 0) ← XΠ(υ = 0) transition.

Establishing a nonzero measurement of the electron Electric Dipole Moment (eEDM) has long been a fundamental pursuit in atomic, molecular and optical physics, offering possible insights into new physics beyond the Standard Model. In this regard, lead monofluoride (PbF) has emerged as a potential candidate for measuring eEDM primarily due to its suitable properties such as the strong internal effective electric field, and eEDM-sensitive ground state with large Ω-doubling and small magnetic g factor. In the present work, we realized the production of a buffer-gas-cooled PbF molecular beam and characterized its high-resolution spectroscopy in the BΣ(υ'=0) ← XΠ(υ = 0) transition, including both direct absorption and laser-induced fluorescence spectroscopy.

Association Between Time to Treatment and Outcomes of Endovascular Therapy vs Medical Management in Patients With Large Ischemic Stroke.

Background And Objectives: Randomized trials have proven the benefit of endovascular therapy (EVT) for acute large ischemic stroke. This study was to characterize the effect of time to treatment on benefit of EVT vs medical management (MM) among patients with large ischemic stroke.

Methods: This was a post hoc analysis of the Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients with a Large Infarct Core randomized trial.

Marine microplastics enrich antibiotic resistance genes (ARGs), especially extracellular ARGs: An investigation in the East China Sea.

The potential of microplastics to carry coexisting pollutants and contribute to combined pollution is a significant health concern. Here we investigate the presence of antibiotic resistance genes (ARGs) in both intracellular ARGs (iARGs) and extracellular ARGs (eARGs) forms, on microplastics collected from the coastal waters of the East China Sea. Our findings revealed that both iARGs and eARGs were enriched on microplastics.

A within-subject voxel-wise constant-block partial least squares correlation method to explore MRI-based brain structure-function relationship.

The brain structure-function relationship is crucial to how the human brain works under normal or diseased conditions. Exploring such a relationship is challenging when using the 3-dimensional magnetic resonance imaging (MRI) functional dataset which is temporal dynamic and the structural MRI which is static. Partial Least Squares Correlation (PLSC) is one of the classical methods for exploring the joint spatial and temporal relationship.

Uncertainty guided semi-supervised few-shot segmentation with prototype level fusion.

Few-Shot Semantic Segmentation (FSS) aims to tackle the challenge of segmenting novel categories with limited annotated data. However, given the diversity among support-query pairs, transferring meta-knowledge to unseen categories poses a significant challenge, particularly in scenarios featuring substantial intra-class variance within an episode task. To alleviate this issue, we propose the Uncertainty Guided Adaptive Prototype Network (UGAPNet) for semi-supervised few-shot semantic segmentation.

Dynamic Rare-Earth Metal-Organic Frameworks Based on Molecular Rotor Linkers with Efficient Emissions and Ultrasensitive Optical Sensing Performance.

4,4',4″-Triphenylamine tricarboxylate (TPA-COOH) with a distinct molecular rotor structure was reacted with rare-earth (RE) metal ions to obtain seven dynamic RE-based luminescent MOFs () (i.e., emission colors in the blue, yellow-green, red, and near-infrared regions and emission peak wavelengths between 400 and 1600 nm) via the effective transfer of absorbed energy from TPA-COOH to the RE metal ions through the antenna effect.

Hourglass-shaped europium cluster-based secondary building unit in metal-organic framework for photocatalytic wastewater purification and sterilization via enhanced reactive oxygen species production.

A large number of diseases caused by water pollution have become a global public health issue, and the development and construction of innovative and efficient photocatalytic systems for water remediation is vital to improve water quality and prevent bacteria-induced diseases. Herein, a europium-based metal-organic framework (Eu-MOF) was self-assembled with complex hourglass-shaped Eu clusters as secondary building units (SBUs), achieving excellent photoinduced reactive oxygen species (ROS) generation ability. Moreover, Eu-MOF can quickly and efficiently degrade organic dyes and kill a variety of bacteria under low-power light irradiation conditions.

Genome-Wide Identification of B-Box Family Genes and Their Potential Roles in Seed Development under Shading Conditions in Rapeseed.

B-box (BBX) proteins, a subfamily of zinc-finger transcription factors, are involved in various environmental signaling pathways. In this study, we conducted a comprehensive analysis of BBX family members in crops. The 482 BBX proteins were divided into five groups based on gene structure, conserved domains, and phylogenetic analysis.

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.

In mammals, global passive demethylation contributes to epigenetic reprogramming during early embryonic development. At this stage, the majority of DNA-methyltransferase 1 (DNMT1) protein is excluded from nucleus, which is considered the primary cause. However, whether the remaining nuclear activity of DNMT1 is regulated by additional mechanisms is unclear.

One-Pot In Situ Construction of a Highly Stable Acylhydrazone-Derived Dy Cluster with Photodynamic Sterilization Property.

The extremely low stability of lanthanide clusters with precise structures and nanometer dimensions in aqueous solutions limits their application in the field of photodynamic sterilization. In this study, an hourglass-shaped nine-nucleated Dy cluster () with excellent light-driven reactive oxygen species (ROS) generation ability and photodynamic sterilization property was constructed using acylhydrazone multidentate chelating ligands obtained via an in situ reaction. The eight chelating ligands were distributed outside cluster , tightly wrapping the cluster core, thus preventing solvent molecules from attacking the cluster nucleus and ensuring the stability of cluster in solution, which was demonstrated via X-ray diffraction and high-resolution electrospray ionization mass spectrometry (HRESI-MS).

Prediction of clear cell renal cell carcinoma ≤ 4cm: visual assessment of ultrasound characteristics versus ultrasonographic radiomics analysis.

Objective: To investigate the diagnostic efficacy of the clinical ultrasound imaging model, ultrasonographic radiomics model, and comprehensive model based on ultrasonographic radiomics for the differentiation of small clear cell Renal Cell Carcinoma (ccRCC) and Renal Angiomyolipoma (RAML).

Methods: The clinical, ultrasound, and contrast-enhanced CT(CECT) imaging data of 302 small renal tumors (maximum diameter ≤ 4cm) patients in Tianjin Medical University Cancer Institute and Hospital from June 2018 to June 2022 were retrospectively analyzed, with 182 patients of ccRCC and 120 patients of RAML. The ultrasound images of the largest diameter of renal tumors were manually segmented by ITK-SNAP software, and Pyradiomics (v3.

Rigid facial motion at study facilitates the holistic processing of own-race faces during the structural encoding stage.

Holistic processing is a fundamental element of face-recognition studies. Some behavioral studies have investigated the impact of rigid facial motion on holistic face processing, yet it is still unclear how rigid motion affects the time course of holistic face processing for different face races. The current study investigated this issue, using the composite face effect (CFE) as a direct measure of holistic processing.

Design, synthesis and biological evaluation of novel SIRT3 inhibitors targeting both NAD and substrate binding sites for the treatment of acute myeloid leukemia.

Acute myeloid leukemia (AML) represents a highly malignant subtype of leukemia with limited therapeutic options. In this study, we propose a novel therapeutic strategy for treating AML by inhibiting SIRT3 to regulate mitochondrial metabolism network involved in energy metabolism and epigenetic modifications essential for AML survival. A series of thieno [3,2-d]pyrimidine-6-carboxamide derivatives were designed and synthesized by structure-based strategy, 17f was documented to be a potent and acceptable selective SIRT3 inhibitor with IC value of 0.

Effect of Stroke Etiology on Endovascular Treatment for Acute Basilar-Artery Occlusion: A Post Hoc Analysis of the ATTENTION Randomized Trial.

Background: Stroke etiology could influence the outcomes in patients with basilar-artery occlusion (BAO). This study aimed to evaluate the differences in efficacy and safety of best medical treatment (BMT) plus endovascular treatment (EVT) versus BMT alone in acute BAO across different stroke etiologies.

Methods: The study was a post hoc analysis of the ATTENTION trial (Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion), which was a multicenter, randomized trial at 36 centers in China from February 2021 to September 2022.

Iterative Chebyshev approximation method for optimal control problems.

We present a novel numerical approach for solving nonlinear constrained optimal control problems (NCOCPs). Instead of directly solving the NCOCPs, we start by linearizing the constraints and dynamic system, which results in a sequence of sub-problems. For each sub-problem, we use finite number of Chebyshev polynomials to estimate the control and state vectors.

Evaluation of image-pro plus assisted superb microvascular imaging for differential diagnosis of renal masses.

Objective: Previous research on diagnostic assessment by superb microvascular imaging (SMI) were based on qualitative or semi-quantitative assessments of vascularity, which may be subjective and unrepeatable by different sonographers. This study aimed to evaluate diagnostic performance of SMI Image-pro Plus (IPP) based vascular index (VI) for malignant renal masses.

Method: We retrospectively reviewed 222 masses in 214 patients who underwent SMI between August 2019 and August 2022 in our study.

Preoperative Differentiation of HER2-Zero and HER2-Low from HER2-Positive Invasive Ductal Breast Cancers Using BI-RADS MRI Features and Machine Learning Modeling.

Background: Accurate determination of human epidermal growth factor receptor 2 (HER2) is important for choosing optimal HER2 targeting treatment strategies. HER2-low is currently considered HER2-negative, but patients may be eligible to receive new anti-HER2 drug conjugates.

Purpose: To use breast MRI BI-RADS features for classifying three HER2 levels, first to distinguish HER2-zero from HER2-low/positive (Task-1), and then to distinguish HER2-low from HER2-positive (Task-2).

Spin-State Control in Dysprosium(III) Metallacrown Magnets via Thioacetal Modification.

Integrating controllable spin states into single-molecule magnets (SMMs) enables precise manipulation of magnetic interactions at a molecular level, but remains a synthetic challenge. Herein, we developed a 3d-4f metallacrown (MC) magnet [DyNi(quinha)(sal)(py)](ClO) ⋅ 4HO (Hquinha=quinaldichydroxamic acid, Hsal=5-chlorosalicylaldehyde) wherein a square planar Ni is stabilized by chemical stacking. Thioacetal modification was employed via post-synthetic ligand substitutions and yielded [DyNi(quinha)(saldt)(py)](ClO) ⋅ 3HO (Hsaldt=4-chloro-2-(1,3-dithiolan-2-yl)phenol).