DeepCancerMap: A versatile deep learning platform for target- and cell-based anticancer drug discovery.

Discovering new anticancer drugs has been widely concerned and remains an open challenge. Target- and phenotypic-based experimental screening represent two mainstream anticancer drug discovery methods, which suffer from time-consuming, labor-intensive, and high experimental costs. In this study, we collected 485,900 compounds involving in 3,919,974 bioactivity records against 426 anticancer targets and 346 cancer cell lines from academic literature, as well as 60 tumor cell lines from NCI-60 panel.

Correlation analysis of Blood TM, TG and D-dimer with deep venous Thrombosis formation in patients after Total Hip Arthroplasty.

Objective: To explore the correlation of blood thrombomodulin (TM), triglyceride (TG) and D-Dimer (D-D) with the formation of deep vein thrombosis (DVT) in patients after total hip arthroplasty (THA).

Methods: A retrospective analysis was carried out focusing on the clinical data of 150 patients with THA who were admitted to Sichuan Provincial Orthopedic Hospital from May 2019 to May 2022 (the study group). These patients were then subdivided into Group-A (46 cases with DVT) and Group-B (104 cases without DVT) according to whether DVT occurred after an operation.

Intrathyroidal Thymic Carcinoma: A Retrospective Case Series Study.

Objective: Intrathyroidal thymic carcinoma (ITC) is a rare low-grade malignant thyroid tumor. There is neither sufficient understanding of this tumor nor its clinical treatment. This study is to explore the clinicopathological features, treatment, and prognosis of ITC and thereby provide a reference for the diagnosis and treatment of the disease.

The complete chloroplast genome of (Gramineae).

(Guatemalan grass) is a perennial fodder grasses, which is commonly growing in large parts of Africa for a source of livestock feed. It has a high economic value as a forage. In this study, we obtained a complete chloroplast genome of by Illumina sequencing.

Linking microbial community and biological functions to redox potential during black-odor river sediment remediation.

The black-odor phenomenon in polluted urban rivers is a serious environmental problem that has received increasing attention in the recent years. The low redox potential (less than - 100 mV) in the sediment is considered to be the key factor causing the occurrence of black-odor phenomenon. Here, we studied the structure and function of the microbial community during the remediation of urban rivers.

Ceramsite Facilitated Microbial Degradation of Pollutants in Domestic Wastewater.

Although constructed wetlands (CWs) are widely used around the world with various substrates, the mechanisms of how these modified substrates affect wastewater treatment are still unknown. In this study, CW microcosms were established with and without ceramsite as a substrate, and the wastewater treatment efficiencies were evaluated during 71 days of incubation. Using the 16S rRNA high-through sequencing, the mechanisms of how CW substrate changed the microbial community was quantified.

Complete genome sequence of the dissimilatory azo reducing thermophilic bacterium Novibacillus thermophiles SG-1.

With the isolation and identification of efficient azo-dye degradation bacteria, bioaugmentation with specific microbial strains has now become an effective strategy to promote the bioremediation of azo dye. However, Azo dye wastewater discharged at high temperature restricted the extensive application of the known mesophilic azoreducing microorganisms. Here we present the complete genome sequence of a bacterium capable of reducing azo dye under thermophilic condition, Novibacillus thermophiles SG-1 (=KCTC 33118 =CGMCC 1.

[Spectroscopic Characterization of DOM During Hyperthermophilic Composting of Sewage Sludge].

Spectroscopy methods such as three-dimensional excitation-emission (3D-EEM) fluorescence spectroscopy were applied to analyze the structures and changes of DOM in hyperthermophilic composting of sewage sludge to fully understand the advantages of hyperthermophilic composting in promoting sludge maturity. The results showed that the temperature reached its peak value at 90℃ and remained over 80℃ for 5 d. The thermophilic period more than 50℃ lasted for 22 d.

Enhanced electrosynthesis performance of Moorella thermoautotrophica by improving cell permeability.

Microbial electrosynthesis systems (MES) are promising devices in which microbes obtain electrons from electrodes to produce extracellular multicarbon compounds. This study investigates whether improvement in cell permeability can enhance electrosynthesis performance of Gram-positive Moorella thermoautotrophica in MES. Results showed that when ≤30mg/L penicillin was added, the cell permeability was doubled, and the electron uptake per biomass (including both cathode-associated biomass and suspended biomass) was 1.

[Analysis of 33 children with deep neck infection].

Objective: To analyze the effective treatment of deep neck infection in children.

Methods: Thirty-three cases of deep neck infection treated from September 2005 to May 2015 were retrospectively reviewed. To observe the effect of antibiotics and surgical drainage.

[The clinical analysis of thyriod carcinoma showing thymus-like differentiation].

Objective: To investigate the clinical diagnosis, treatment and prognosis of carcinoma showing thymus-like differentiation (CASTLE) of thyroid, and to improve the understanding of CASTLE.

Method: In 6 patients with CASTLE, we performed region VI lymph node dissection, the lesion resection of thyroid lobe and isthmus. After the operation, except one case of 68 years old patient, the rest patients were treated with radiotherapy 60 Gy in anterior cervical region after third week of operation and 5 courses of chemotherapy with cisplatin, each interval of 2 weeks.

Highly efficient graphene-based Cu(In, Ga)Se₂ solar cells with large active area.

Two-dimensional graphene has tremendous potential to be used as a transparent conducting electrode (TCE), owing to its high transparency and conductivity. To date graphene films have been applied to several kinds of solar cells except the Cu(In, Ga)Se₂ (CIGS) solar cell. In this work, we present a novel TCE structure consisting of a doped graphene film and a thin layer of poly(methyl methacrylate) (PMMA) to replace the ZnO:Al (AZO) electrode for CIGS.

[Expression of Survivin and Bcl-2 in sinonasal inverted papilloma].

Objective: To investigate the expression of Survivin and its relationship with the expression of Bcl-2 in sinonasal inverted papilloma (SNIP).

Method: Immunohistochemical method was used to determine the expression of Survivin and Bcl-2 in 30 cases of SNIP, 10 cases of sinonasal squamous cell carcinoma (SCC) and 10 cases of normal inferior concha tissues.

Result: Survivin was expressed in 22 of 30 (73.