Predictive Modeling of Endograft Limb Occlusion After Endovascular Aneurysm Repair: A Propensity Score Matching Analysis.

Background: Endovascular aneurysm repair (EVAR) is widely used to treat abdominal aortic aneurysm (AAA). However, it carries the risk of complications that often require further interventions. Endograft limb occlusion (ELO), though relatively rare, significantly affects patient outcomes.

Synergistic Effect of Polyurethane on Pore-Sealing and Lubrication of Microarc Oxidation Coating.

Microarc oxidation (MAO) is a widely used surface treatment technology. However, its processing inevitably leads to the presence of micropores, microcracks, and other defects in the MAO coating. These defects lead to suboptimal tribological performance and diminished corrosion resistance of the MAO coating.

Breathomics for diagnosing tuberculosis in diabetes mellitus patients.

Introduction: Individuals with diabetes mellitus (DM) are at an increased risk of (Mtb) infection and progressing from latent tuberculosis (TB) infection to active tuberculosis disease. TB in the DM population is more likely to go undiagnosed due to smear-negative results.

Methods: Exhaled breath samples were collected and analyzed using high-pressure photon ionization time-of-flight mass spectrometry.

Variations in Quinolinic Acid Levels in Tuberculosis Patients with Diabetes Comorbidity: A Pilot Prospective Cohort Study.

Objective: We aimed to investigate dysregulated metabolic pathways and identify diagnostic and therapeutic targets in patients with tuberculosis-diabetes (TB-DM).

Methods: In our prospective cohort study, plasma samples were collected from healthy individuals, diabetic (DM) patients, untreated TB-only (TB-0)/TB-DM patients (TB-DM-0), and cured TB (TB-6)/TB-DM patients (TB-DM-6) to measure the levels of amino acids, fatty acids, and other metabolites in plasma using high-throughput targeted quantification methods.

Results: Significantly different biological processes and biomarkers were identified in DM, TB-DM-0, and TB-DM-6 patients.

Engineered Cellular Vesicles Displaying Glycosylated Nanobodies for Cancer Immunotherapy.

Immune checkpoint blockade targeting the CD47/SIRPα axis represents an alluring avenue for cancer immunotherapy. However, the compromised efficacy and safety concerns in vivo of conventional anti-CD47 antibodies impede their wide clinical applications. Here we introduced a single type of high-mannose glycans into the nanobody against CD47 (HM-nCD47) and subsequently displayed HM-nCD47 on cellular vesicles (CVs) for enhanced cancer immunotherapy.

Myriocin enhances the clearance of by macrophages through the activation of PLIN2.

Myriocin is an inhibitor of synthesis of sphingolipids and ceramides. In this research, we showed myriocin could significantly reduce Mtb burden and histopathological inflammation in mice. However, the underlying mechanism remains unclear.

Effect of Treatment with Microarc Oxidation Technology on Tribological Properties of Nonvalve Metal Low-Carbon Steel.

Steel is one of the most widely used alloys because of its excellent properties such as high toughness, good workability, and low cost. However, steel has weak wear resistance, which limits its range of applications and service life. We have used the microarc oxidation (MAO) technique to form an AlO ceramic coating on the surface of nonvalve metal low-carbon steel, which is used to enhance the wear resistance of low-carbon steel.

Tribological properties of MAO ceramic coatings with annulus array texture on disposable surgical gloves.

In recent research, the expansion in the use of Mg alloys for biomedical applications has been approached by modifying their surfaces in conjunction with micro-arc oxidation (MAO) techniques which enhance their abrasion and corrosion resistance. In this study, combining laser texturing and MAO techniques to produce the dense ceramic coatings with microstructures. On the surface of the AZ31 Mg alloy, a micro-raised annulus array texture has been designed in order to increase the surface friction under liquid lubrication and to improve the operator's grip when holding the tool.

Association between lactate metabolism‑related molecules and venous thromboembolism: A study based on bioinformatics and an model.

Venous thromboembolism (VTE) is characterized by a high recurrence rate and adverse consequences, including high mortality. Damage to vascular endothelial cells (VECs) serves a key role in VTE and lactate (LA) metabolism is associated with VEC damage. However, the pathogenesis of VTE and the role of lactate metabolism-related molecules (LMRMs) remain unclear.

Effects and regulatory pathway of proopinmelanocortin on feeding habit domestication in mandarin fish.

Proopiomelanocortin (POMC) is a hormone precursor, and has been reported to participate in domestication. However, its effects on feeding habit domestication in fish are poorly understood. Mandarin fish (Siniperca chuatsi) feeds solely on live prey fish since first-feeding.

Random Traffic Flow Simulation of Heavy Vehicles Based on R-Vine Copula Model and Improved Latin Hypercube Sampling Method.

The rationality of heavy vehicle models is crucial to the structural safety assessment of bridges. To establish a realistic heavy vehicle traffic flow model, this study proposes a heavy vehicle random traffic flow simulation method that fully considers the vehicle weight correlation based on the measured weigh-in-motion data. First, a probability model of the key parameters in the actual traffic flow is established.

Small Molecule-Activated -GlcNAcase for Spatiotemporal Removal of -GlcNAc in Live Cells.

The nutrient sensor O-linked -acetylglucosamine (-GlcNAc) is a post-translational modification found on thousands of nucleocytoplasmic proteins. -GlcNAc levels in cells dynamically respond to environmental cues in a temporal and spatial manner, leading to altered signal transduction and functional effects. The spatiotemporal regulation of -GlcNAc levels would accelerate functional interrogation of -GlcNAc and manipulation of cell behaviors for desired outcomes.

Kruppel-like Factors 3 Regulates Migration and Invasion of Gastric Cancer Cells Through NF-κB Pathway.

Context: The poorly understood regulatory mechanisms impede gastric cancer therapy. Kruppel-like factors (KLFs) are associated with the development of various tumors, The studies on the role of the KLF transcription factor 13 (KLF13) in gastric cancer progression haven't been studied.

Objective: The current study aimed to investigate the role of KLF13 in the migration and invasion of gastric cancer and the regulatory mechanism of KLF13 in gastric cancer progression.

Anterior cervical discectomy and fusion with zero-profile versus stand-alone cages for two-level cervical spondylosis: A retrospective cohort study.

Objective: To assess the mid-long-term clinical and radiological outcomes of zero-profile (ZP) compared with stand-alone (ST) cages for two-level anterior cervical discectomy and fusion (ACDF).

Methods: We included 77 patients (39 women and 38 men) who underwent two-level ACDF between May 5, 2016, and May 5, 2020, and who were followed up for at least 1 year. The subjects were divided into the ST ( = 38) and ZP ( = 39) group.

Preparation and performance study of a reactive polyurethane hot-melt adhesive/CS-FeO magnetic nanocomposite film/fabric.

Magnetic nanoparticles are attracting significant attention for their wide application as biomaterials and magnetic storage materials. As an environmentally friendly adhesive, reactive polyurethane hot-melt adhesive (PUR) is a biocompatible polymer with a wide range of applications. In this paper, chitosan (CS)-surface-modified magnetic FeO nanoparticles were synthesized by the sol-gel method.

Preparation and characterization of polyethylene glycol/chitosan composite water-based wound healing lubricant.

The proportion of pregnant women giving birth through cesarean section is increasing annually worldwide. However, post-cesarean section scar diverticulum is a common condition that occurs and requires better surgical strategies than the methods currently used. We hypothesized that using biological lubricant topically on the incision area during C-section could be an option to minimize the scar.

Cytocompatibility of pH-sensitive, chitosan-coated FeO nanoparticles in gynecological cells.

Nanoparticles that contact human cells without damaging basic human tissues are becoming more widely used in medicine. Efficient delivery to the intracellular target cell or compartment through the cell membrane must be achieved with minimal cytotoxicity to healthy cells. FeO nanoparticles have been widely used in biomedical research for their magnetic, non-toxic, and biocompatible properties.

Lysine Deprivation Regulates Npy Expression via GCN2 Signaling Pathway in Mandarin Fish ().

Regulation of food intake is associated with nutrient-sensing systems and the expression of appetite neuropeptides. Nutrient-sensing systems generate the capacity to sense nutrient availability to maintain energy and metabolism homeostasis. Appetite neuropeptides are prominent factors that are essential for regulating the appetite to adapt energy status.

Curcumin attenuates vascular calcification via the exosomal miR-92b-3p/KLF4 axis.

Vascular calcification (VC) is the most widespread pathological change in diseases of the vascular system. However, we do not have a good understanding of the molecular mechanisms and effective therapeutic approaches for VC. Curcumin (CUR) is a natural polyphenolic compound that has hypolipidemic, anti-inflammatory, and antioxidant effects on the cardiovascular system.

Overexpression of microRNA-145 enhanced docetaxel sensitivity in breast cancer cells via inactivation of protein kinase B gamma-mediated phosphoinositide 3-kinase -protein kinase B pathway.

Chemoresistance is a major challenge for the treatment of breast cancer (BC). Previous studies showed that miR-145 level decreases in chemoresistant BC tissues. Nevertheless, the biological function of miR-145 on docetaxel resistance of BC cells remains unclear, which is what our research attempted to clarify.

Preparation of ultra-high mechanical strength wear-resistant carbon fiber textiles with a PVA/PEG coating.

Polyvinyl alcohol (PVA) is an organic polymer that is non-toxic, harmless to the human body, and has good biocompatibility. Polyethylene glycol (PEG) is a polymer that has good lubricity and compatibility. The unique graphite structure of carbon fibers can promote the potential application of carbon-fiber composites in tribology.

Role Mismatch in Medical Decision-Making Participation Is Associated with Anxiety and Depression in Family Members of Patients in the Intensive Care Unit.

This study aimed to investigate the mismatch between the preferred and actual roles in the medical decision-making of intensive care unit (ICU) patients' family members and the relationship between the role mismatch of family members' decisions and anxiety and depression syndromes. A total of 223 family members of ICU patients in the Affiliated Hospital of Jiangnan University in China were enrolled. The simple Chinese version of the Control Preference Scale was used to complete the surveys to assess the preferred and actual roles, and anxiety and depression syndromes were measured using the Generalized Anxiety Disorder-7 scale and Patient Health Questionnaire-9, respectively.

Identification of potential biomarkers of vascular calcification using bioinformatics analysis and validation .

Background: Vascular calcification (VC) is the most widespread pathological change in diseases of the vascular system. However, we know poorly about the molecular mechanisms and effective therapeutic approaches of VC.

Methods: The VC dataset, GSE146638, was downloaded from the Gene Expression Omnibus (GEO) database.

Identification of potential biomarkers for diagnosis of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) has a high mortality rate owing to its complexity. Identification of abnormally expressed genes in HCC tissues compared to those in normal liver tissues is a viable strategy for investigating the mechanisms of HCC tumorigenesis and progression as a means of developing novel treatments. A significant advantage of the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) is that the data therein were collected from different independent researchers and may be integrated, allowing for a more robust data analysis.