Long noncoding RNA NONHSAT122636.2 attenuates myocardial inflammation and apoptosis in myocarditis.

Objective: The main pathological change of myocarditis is an inflammatory injury of cardiomyocytes. Long noncoding RNAs (lncRNAs) are closely related to inflammation, and our previous study showed that differential expression of lncRNAs is associated with myocarditis. This study aimed to investigate the impact of lncRNAs on the onset of myocarditis.

Study of the mutual coupling characteristics of the oxidation thermal effect and microstructural evolution of gas-containing coal.

Besides be affected by coal confining pressure, coal seams are also be affected by the surrounding pressure during mining. To understand the heat release characteristics and microstructural evolution of oxidization within coal under different gas pressures is of great significance. For this reason, a combination of theoretical research and test analysis was adopted, which includes differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and mercury intrusion method (MIP).

Thermal Insulation Properties and Simulation Analysis of Foam Concrete Regulated by Mechanical and Chemical Foaming.

To address, mitigate, or prevent thermal environmental issues arising from the heat dissipation of high-temperature surrounding rocks in deep hot tunnels, a research proposal is put forward based on previous studies and the team's initial experiments. The proposal involves using mechanical and chemical foaming to enhance the thermal insulation properties of foamed concrete, and this will be tested through engineering verification. Different proportions of cementitious materials, latex powder, polypropylene fiber, and self-made composite foam materials were designed using an orthogonal approach for testing the macroperformance and microstructure of foamed concrete.

Identification and functional analysis of circulating small extracellular vesicle lncRNA signatures in children with fulminant myocarditis.

Fulminant myocarditis (FM) is the most serious type of myocarditis. However, the molecular mechanism underlying the pathogenesis of FM has not been fully elucidated. Small extracellular vesicles (sEVs) play important roles in many diseases, but any potential role in paediatric FM has not been reported.

Oxidation and exothermic properties of long flame coal spontaneous combustion under solid-liquid-gas coexistence and its microscopic mechanism analysis.

Coal spontaneous combustion (CSC) wastes valuable resources and does great damage to the environment. To study the oxidation and exothermic properties of CSC under solid-liquid-gas coexistence conditions, a C600 microcalorimeter was used to analyze the heat released by the oxidation of raw coal (RC) and water immersion coal (WIC) under different air leakage (AL) conditions. The experimental results showed that the AL was negatively correlated with the heat release intensity (HRI) in the initial stages of coal oxidation, but as the oxidation proceeded, the AL and the HRI gradually showed positive correlations.

Altered plasma exosome miRNAs and novel potential biomarkers in pediatric fulminant myocarditis.

Previous studies have indicated that exosome-mediated intercellular microRNAs (miRNA) can influence fulminant myocarditis (FM) pathogenesis between immune and cardiac cells. This study explored plasma exosome miRNA profile in pediatric FM using a small RNA microarray. As per our analysis, we observed the differential expression of 266 miRNAs, including 197 upregulated and 69 downregulated candidate genes.

Study on the Influence of Vent Shape and Blockage Ratio on the Premixed Gas Explosion in the Chamber with a Small Aspect Ratio.

Given the current situation of deflagration caused by gas leakage for domestic use and the study of the single shape of the vent, the differential change law of vent parameters on the small aspect ratio of the chamber explosion flame evolution and explosion overpressure and other effects were experimentally investigated. Based on the theory of geometric similarity, the experimental platform of a small length-diameter ratio explosion chamber was designed and built, and the premixed gas explosion experiment was carried out by changing the shape (square and rectangle) and blockage ratio (0.1, 0.

Expression profiles and functional analysis of plasma tRNA-derived small RNAs in children with fulminant myocarditis.

Fulminant myocarditis (FM) has neither validated biomarkers nor well-established therapy. Roles of tRNA-derived small RNAs (tsRNAs) in FM remain unknown. Small RNA sequencing was conducted in plasma from children with FM during acute and convalescent phase and matched healthy volunteers.

Circular RNA circACSL1 aggravated myocardial inflammation and myocardial injury by sponging miR-8055 and regulating MAPK14 expression.

Myocarditis (MC) is a common, potentially life-threatening inflammatory disease of the myocardium. A growing body of evidence has shown that mitogen-activated protein kinase 14 (MAPK14) participates in the pathogenesis of MC. However, the upstream regulators of MAPK14 remain enigmatic.

Differential Expression Profiles and Functional Analysis of Long Non-coding RNAs in Children With Dilated Cardiomyopathy.

To evaluate the expression profile of long non-coding RNAs (lncRNAs) in different left ventricular function of dilated cardiomyopathy (DCM) in children and explore their possible functions. The lncRNA microarray experiment was used to determine the differential expression profile of lncRNA in three children with DCM and three healthy volunteers. The functional analysis and the construction of the lncRNA-mRNA interaction network were carried out to study the biological functions.

Differential Expression Profiles and Functional Prediction of Circular RNAs in Pediatric Dilated Cardiomyopathy.

Circular RNAs (circRNAs) have emerged as essential regulators and biomarkers in various diseases. To assess the different expression levels of circRNAs in pediatric dilated cardiomyopathy (PDCM) and explore their biological and mechanistic significance, we used RNA microarrays to identify differentially expressed circRNAs between three children diagnosed with PDCM and three healthy age-matched volunteers. The biological function of circRNAs was assessed with a circRNA-microRNA (miRNA)-mRNA interaction network constructed from Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes.

Long Non-coding RNA Expression Profile and Functional Analysis in Children With Acute Fulminant Myocarditis.

Long non-coding RNA (lncRNA) has been associated with human diseases. To study the role of lncRNA in the pathogenic mechanism of acute fulminant myocarditis (AFM), we used a microarray to analyze lncRNA and messenger RNA (mRNA) expression in leukocyte samples from AFM patients and normal children. In total, using a 2/0.

Differential expression profiles and functional analysis of circular RNAs in children with fulminant myocarditis.

To assess differential expression profiles of circular RNAs (circRNAs) and explore their possible functions in children with fulminant myocarditis. circRNA microarray experiments were carried out for determining differential expression profiles of circRNAs in three children with fulminant myocarditis and three healthy volunteers. Functional analysis and circRNA-miRNA-mRNA interaction network building were conducted to study biological functions.

Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases.

Interleukin-37 (IL-37) is an IL-1 family cytokine discovered in recent years and has 5 different isoforms. As an immunosuppressive factor, IL-37 can suppress excessive immune response. IL-37 plays a role in protecting the body against endotoxin shock, ischemia-reperfusion injury, autoimmune diseases, and cardiovascular diseases.